Antagonizing serotonin 2A (5-HT2A) receptors attenuates methamphetamine-induced reward and blocks methamphetamine-induced anxiety-like behaviors in adult male rats

Madden, John T.; Reyna, Nicole C.; Pentkowski, Nathan S.

doi:10.1016/j.drugalcdep.2020.108178

Cited by 8 publications

(1 citation statement)

References 63 publications

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“…She fulfilled Hunter criteria for serotonin syndrome (18). Preclinical studies have suggested that methamphetamine acts as a serotonin 5-HT2A agonist (19). It is probable that the patient's isolated methamphetamine ingestion acted as the inciting event in the context of kratom and a serotonin reuptake inhibitor.…”

Section: Discussionmentioning

confidence: 99%

A case of a mixed overdose involving kratom (Mitragyna speciosa) leading to serotonin syndrome

Browne

Levine

2021

Med Sci Discov

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Objective: Drug overdose deaths have risen precipitously over the past two years in the United States. Polysubstance overdose with opiates and amphetamines have been of particular concern. Kratom (Mitragyna speciosa) is an unregulated widely available herb with both stimulant and opiate μ-receptor activity. Studies suggest that its use is quickly increasing. Case: We describe a patient who presented to a psychiatric hospital with a mixed toxic syndrome due to chronic kratom and prescribed SSRI use compounded by acute intake of methamphetamine. The patient displayed psychosis, tremulousness, myoclonus, and extreme anxiety. Her clinical picture was consistent with both serotonin syndrome and opiate withdrawal. Conclusion: We call attention to this case because polysubstance overdoses are common, and kratom is widely available. Complex toxic presentations that involve kratom are likely to be increasingly encountered.

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Section: Discussionmentioning

confidence: 99%