The development of a robust understanding of the response of the Antarctic Ice Sheet to present and projected future climatic change is a matter of key global societal importance. Numerical ice sheet models that simulate future ice sheet behaviour are typically evaluated with recourse to how well they reproduce past ice sheet behaviour, which is constrained by the geological record. However, subglacial topography, a key boundary condition in ice sheet models, has evolved significantly throughout Antarctica's glacial history. Since mantle processes play a fundamental role in the generation and modification of topography over geological timescales, an understanding of the interactions between the Antarctic mantle and palaeotopography is crucial for developing more accurate simulations of past ice sheet dynamics. This chapter provides a review of the influence of the Antarctic mantle on the long-term evolution of the subglacial landscape, through processes including structural inheritance, flexural isostatic adjustment, lithospheric cooling and thermal subsidence, volcanism and dynamic topography. The uncertainties associated with reconstructing these processes through time are discussed, as are important directions for future research and the implications of the evolving subglacial topography for the response of the Antarctic Ice Sheet to climatic and oceanographic change.