Antenatal depression: Efficacy of a pre-post therapy study and repercussions in motor development of children during the first 18 months postpartum. Study: “Pregnancy care, healthy baby”

Pinheiro, Ricardo Tavares; Souza, Luciano Dias de Mattos; Trettim, Jéssica Puchalski; Matos, Mariana Bonati de; Pinheiro, Karen Amaral Tavares; Cunha, Gabriela Kurz da; Rubin, Bárbara Borges; Scholl, Carolina Coelho; Stigger, Rafaelle Stark; Motta, Janaína Vieira dos Santos; Oliveira, Sandro Schreiber de; Ghisleni, Gabriele; Nedel, Fernanda; Quevedo, Luciana de Ávila

doi:10.1016/j.jpsychires.2022.01.061

Cited by 11 publications

(11 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is important to highlight that these results are independent of mothers presenting severe depression during the first two trimesters of pregnancy and undergoing intervention by cognitive behavioral therapy. However, the intervention in this group, proposed by the project, was able to impact on the better motor development of children, as shown in the article published by the group ( Pinheiro et al, 2022 ). The results presented in our article, so far, have not been demonstrated in any study, especially concerning populational studies.…”

Section: Discussionmentioning

confidence: 91%

See 1 more Smart Citation

Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the neuropsychomotor development of 90 days old babies: "Pregnancy care, healthy baby" study

Nedel

Ferrúa

Amaral

et al. 2023

Journal of Psychiatric Research

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 91%

“…The cohort project to which this case is linked was approved by the committee of research ethics of the Catholic University of Pelotas, under report number 1.729.653. For more details on sample capturing, read the publications of Pinheiro et al, 2021 , 2022 .…”

Section: Methodsmentioning

confidence: 99%

Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the neuropsychomotor development of 90 days old babies: "Pregnancy care, healthy baby" study

Nedel

Ferrúa

Amaral

et al. 2023

Journal of Psychiatric Research

Self Cite

View full text Add to dashboard Cite

“…Early intervention during pregnancy could have important clinical implications reducing the impact of psychopathology on maternal and child health. Even if the possible efficacy of different interventions has yet to be explored, a very recent study indicates that cognitive-behavioral psychotherapy interventions on depression during pregnancy were shown to be effective in indirectly improving infant motor development during the first 18 months after birth ( 75 ). Understanding the prenatal and postpartum mechanisms underlying these relationships would help design more appropriate timing of successful prenatal and/or postpartum interventions, as well as identifying a gestational age of increased vulnerability would change the direction of research in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Maternal perinatal depression and child neurocognitive development: A relationship still to be clarified

et al. 2023

View full text Add to dashboard Cite

Pregnancy frequently is associated with emotional conditions such as anxiety and depression. Perinatal depression has an incidence of around 12%. Only recently researcher put the attention on the effects of pre- and postpartum psychopathology on infant neurocognitive development. Neurobiology studies indicate that perinatal maternal depression can significantly affect the structure and function of children’s prefrontal cortex and modulate the development of cognitive abilities from intrauterine life. On the topic, the scientific literature appears ambiguous, reporting mixed results. Some studies have found no significant differences in developmental outcomes between prenatal and postpartum exposure to maternal depression, others have suggested a greater burden of depression in pregnancy than in postpartum, and still others have emphasized the role of chronicity of symptoms rather than the period of onset. Few studies have examined the effects of different developmental trajectories of maternal depression on children’s neurocognitive outcomes. The assessment of maternal health has for years been limited to postpartum depression often neglecting the timing of onset, the intensity of symptoms and their chronicity. These aspects have received less attention than they deserve, especially in relation to the effects on children’s neurocognitive development. The aim of this Perspective was to highlight inconsistencies and gaps that need to be filled in the approach to the study of this problem. Given the wide heterogeneity of data in the current literature, further studies are needed to clarify these interactions. This Perspective provides an overview of current progress, future directions, and a presentation of the authors’ views on the topic.

show abstract

“…The cohort project to which this case is linked was approved by the committee of research ethics of the Catholic University of Pelotas, under-report number 1.729.653. For more details on sample capturing, read the publications of Pinheiro et al ( 22 , 23 ).…”

Section: Methodsmentioning

confidence: 99%

Can glutathione be a biomarker for suicide risk in women 18 months postpartum?

et al. 2023

Self Cite

View full text Add to dashboard Cite

BackgroundSuicide risk is prominent among the problems affecting populations, mainly due to the broad family, psychosocial and economic impact. Most individuals at suicidal risk have some mental disorder. There is considerable evidence that psychiatric disorders are accompanied by the activation of neuro-immune and neuro-oxidative pathways. The aim of the study is to evaluate the serum levels of oxidative stress biomarkers in women at risk of suicide after 18 months of postpartum.MethodsThis is a case-control study, nested within a cohort study. From this cohort, 45 women [15 without mood disorders and 30 with mood disorders (Major depression and Bipolar disorder)] were selected at 18 months postpartum, the depression and suicide risk were assessed using the Mini-International Neuropsychiatric Interview Plus (MINI-Plus) instrument, module A and C, respectively. Blood was collected and stored for later analysis of the reactive species (DCFH), superoxide dismutase (SOD), and glutathione reduced (GSH). For data analysis, the SPSS program was used. To compare the nominal covariates with the outcome GSH levels, the Student’s t-test or analysis of variance (ANOVA) was used. Spearman’s correlation was performed for analysis between the quantitative covariates and the outcome. To analyze the interaction between the factors, multiple linear regression was performed. Bonferroni analysis was used as an additional/secondary result to visualize differences in glutathione levels according to risk severity. After the adjusted analysis, p-values < 0.05 were considered statistically significant.ResultsThe percentage of suicide risk observed in our sample of women at 18 months postpartum was 24.4% (n = 11). After adjusting for the independent variables, only the presence of suicide risk remained associated with the outcome (β = 0.173; p = 0.007), low levels of GSH at 18 months after postpartum. Likewise, we verified the difference in GSH levels according to the degree of suicide risk, observing a significant association between the differences in glutathione means in the group of women with moderate to high risk compared to the reference group (no suicide risk) (p = 0.009).ConclusionOur findings suggest that GSH may be a potential biomarker or etiologic factor in women at moderate to high risk of suicide.

show abstract

Antenatal depression: Efficacy of a pre-post therapy study and repercussions in motor development of children during the first 18 months postpartum. Study: “Pregnancy care, healthy baby”

Cited by 11 publications

References 38 publications

Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the neuropsychomotor development of 90 days old babies: "Pregnancy care, healthy baby" study

Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the neuropsychomotor development of 90 days old babies: "Pregnancy care, healthy baby" study

Maternal perinatal depression and child neurocognitive development: A relationship still to be clarified

Can glutathione be a biomarker for suicide risk in women 18 months postpartum?

Contact Info

Product

Resources

About