Antenatal Transplacental Hemorrhage

Abstract

A transplacental hemorrhage of approximately 10 ml occurred at the 29th week of the first pregnancy of a woman carrying twins. The administration of 400 μg Rh immunoglobulin 96 hours later failed to prevent primary immunization. Traces of saline‐reacting anti‐Rh0 (D) were detectable by the 32nd week, increasing to a titer of 1: 64 by the 37th week of pregnancy. The possibility that antenatal administration of Rh immunoglobulin may enhance the risk of primary immunization is considered.

Australia Antigen in Rhodesia

“…Else where in Southern Africa the antigen was demonstrated in 3,4 per cent, of a random sample of an apparently normal African 'population (Grobbelaar, 1970). An incidence as high as this implies a real risk in circumstances where blood or blood products are handled or administered as in transfusion, renal dialysis, surgical and haema tology units.…”

Prevention of rhesus isoimmunization

“…The results of this trial will not be known until the subsequent pregnancies have been evaluated. A single case has been reported (from South Africa) by Grobbelaar & Mostert (1970) where a TPH of approximately 10 ml occurred at the 29th week of the first pregnancy and 400 pg of anti-D 96 hours later failed to prevent primary immunization.…”