The paper describes a method for the accurate calibration of multi-channel SAR instruments, such as those required to support SAR polarimetry, single-pass interferometry and digital beam-forming (DBF), on the basis of dedicated SAR acquisitions containing reference targets with known properties. Unlike conventional approaches, the method is based entirely on the analysis of range-compressed raw data. It leverages the pulse-by-pulse analysis of amplitude, phase and delay variations observed within the range histories of reference targets to fully characterize and correct propagation direction dependent calibration issues such as those related to antenna pointing or antenna phase center positions. The fact that the approach does not require SAR image focusing in azimuth is especially relevant in the context of DBF, where individual channels need to be calibrated but are, by themselves, under-sampled. The calibration techniques presented are illustrated and validated using multi-channel polarimetric and single-pass interferometric SAR data acquired by DLR’s airborne F-SAR and DBFSAR instruments.