Anterior abdominal wall metastasis following curative resection and chemoradiation of rectal cancer masquerading as a desmoid tumour: A clinical conundrum

Raveendranadh, Ajay; Goutham, Meera; Gowda, Chiranth; Hegde, Kshama; Monappa, Vidya; Rodrigues, Gabriel

doi:10.1016/j.jtumed.2021.09.001

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…Only limited numbers of case reports describe metastasis at the surgical drain site in patients with pancreatic, cervical, colorectal, thyroid, oesophageal and breast cancer 2. Clinical studies have shown that the incidence of abdominal wall recurrence is approximately 1% after laparotomy for colorectal cancer 3. This case reports the rare presentation of port-site recurrence post resection and adjuvant chemotherapy for a primary colorectal tumour at the ileocaecal valve.…”

Section: Discussionmentioning

confidence: 89%

“…When investigating an asymptomatic abdominal wall lesion, biopsy and histological assessment is required to differentiate between pathologies. This can help differentiate between other benign presentations such as hyperplastic granulation tissue, keloid scars and desmoid tumours 3. Hughes et al conducted a case series whereby 11 of 1603 patients developed recurrence at their abdominal incision after curative resection of large bowel cancer 11.…”

Section: Discussionmentioning

confidence: 99%

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Drain-site recurrence of an ileocaecal valve adenocarcinoma

Kowlessar,

O'Brien,

Shabo

et al. 2024

BMJ Case Rep

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Drain-site recurrence following colorectal cancer resection is a rare event and is described in few case reports. The majority of these reports are following minimally invasive surgery. This report describes a case of an isolated drain-site recurrence of primary colorectal cancer in a male patient in his 50s. He previously underwent an open right hemicolectomy and segmental small bowel resection for an obstructing ileocaecal valve adenocarcinoma. This was followed by adjuvant chemotherapy. Two years into surveillance, a redo ileocolic resection was performed for an anastomotic recurrence. While undergoing surveillance imaging, a new deposit was detected at a right-sided surgical drain site. Subsequently, a full thickness en bloc resection was performed. To date, the postoperative course has been uneventful. This case describes a drain-site recurrence from a colorectal primary.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Drain-site recurrence of an ileocaecal valve adenocarcinoma

Kowlessar,

O'Brien,

Shabo

et al. 2024

BMJ Case Rep

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“… 2 According to the latest World Health Organization (WHO) classification of soft tissue and bone tumors, a DT is an intermediate-grade neoplasm characterized by an invasive growth pattern into surrounding normal structures and, rarely, metastasis. 3 , 4 DTs are relatively rare, accounting for less than 3% of soft tissue tumors. 3 The invasive nature of DTs is evident from the propensity of the tumor cells to invade and engulf surrounding normal structures.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological assessment of PD-1/PD-L1 immune checkpoint expression in desmoid tumors

et al. 2023

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The details of immune molecules' expression in desmoid tumors (DTs) remain unclear. This study aimed to determine the expression status of the programmed death-1/programmed death ligand 1 (PD1/PD-L1) immune checkpoint mechanism in DTs. The study included patients with DTs (n=9) treated at our institution between April 2006 and December 2012. Immunostaining for CD4, CD8, PD-1, PD-L1, interleukin-2 (IL-2), and interferon-gamma (IFN-γ) was performed on pathological specimens harvested during the biopsy. The positivity rate of each immune component was calculated as the number of positive cells/total cells. The positivity rate was quantified and correlations between the positivity rates of each immune molecule were also investigated. Immune molecules other than PD-1 were stained in tumor cells and intra-tumor infiltrating lymphocytes. The mean ± SD expression rates of β-catenin, CD4, CD8, PD-1, PD-L1, IL-2, and IFN-ɤ were 43.9±18.9, 14.6±6.80, 0.75±4.70, 0±0, 5.1±6.73, 8.75±6.38, and 7.03±12.1, respectively. The correlation between β-catenin and CD4 was positively moderate (r=0.49); β-catenin and PD-L1, positively weak (r=0.25); CD4 and PD-L1, positively medium (r=0.36); CD8 and IL-2, positively medium (r=0.38); CD8 and IFN-ɤ, positively weak (r=0.28); and IL-2 and IFN-ɤ, positively medium (r=0.36). Our findings suggest that PD-L1-centered immune checkpoint mechanisms may be involved in the tumor microenvironment of DTs.

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“…[2] According to the latest World Health Organization classification of soft tissue and bone tumors, a DT is an intermediate-grade neoplasm characterized by an invasive growth pattern into the surrounding normal structures and, very rarely, metastasis. [3,4] The invasive nature of DTs is evidenced by the propensity of tumor cells to invade and engulf surrounding normal structures, which poses an imminent danger when they grow adjacent to major blood vessels and other vital organs. [5,6] However, the pathogenesis of DTs remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Involvement of NY-ESO-1 and MAGE-A4 in the pathogenesis of desmoid tumors

et al. 2023

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The involvement of New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and melanoma-associated antigen A4 (MAGE-A4) in soft-tissue sarcoma pathogenesis has recently been reported; however, their involvement in desmoid tumors (DTs) remains unknown. This study aimed to determine the involvement of NY-ESO-1 and MAGE-A4 in DTs. Immunostaining for β-catenin, NY-ESO-1, and MAGE-A4 was performed on DT biopsy specimens harvested at our institution. The positivity rate for each immune component was calculated. In addition, the correlations between the positivity rates for the immune molecules were investigated. The correlation between the positivity rate and age or longest diameter of each immune molecule was also investigated. β-catenin showed staining mainly in the tumor cell nuclei of DTs. Both NY-ESO-1 and MAGE-A4 showed staining in the nucleus, cytoplasm, and infiltrating lymphocytes of DT cells. The mean positive cell rates for β-catenin, NY-ESO-1, and MAGE-A4 were 43.9 ± 21.7, 30 ± 21.6, and 68.9 ± 20.8, respectively. A strong negative correlation was observed between β-catenin and MAGE-A4 positivity rates (r = −0.64). The positivity rates for NY-ESO-1 and MAGE-A4 showed a moderate positive correlation (r = −0.42). A very strong negative correlation was observed between age and the NY-ESO-1 positivity rate (r = −0.72). A weak negative correlation was observed between age and the MAGE-A4 positivity rate (r = −0.28). A medium negative correlation was observed between the longest tumor diameter and NY-ESO-1 positivity (r = −0.37). NY-ESO-1 and MAGE-A4 may be involved in the DT microenvironment. Thus, NY-ESO-1 and MAGE-A4 may be useful in the diagnosis of DT.

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Anterior abdominal wall metastasis following curative resection and chemoradiation of rectal cancer masquerading as a desmoid tumour: A clinical conundrum

Cited by 3 publications

References 8 publications

Drain-site recurrence of an ileocaecal valve adenocarcinoma

Drain-site recurrence of an ileocaecal valve adenocarcinoma

Clinicopathological assessment of PD-1/PD-L1 immune checkpoint expression in desmoid tumors

Involvement of NY-ESO-1 and MAGE-A4 in the pathogenesis of desmoid tumors

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