A prospective comparative analysis, i.e. the results of treatment of 68 patients, was carried out. The focal form of chronic post-traumatic osteomyelitis of the distal third of the tibia was focused. All patients were subjected to surgical debridement of the osteomyelitic focus on the variant of osteonecrectomy, followed by myoplastic reconstruction of the formed bone defect with chopped autologous muscle. In 30 patients, the traditional method of myoplastic reconstruction was used, and in 38 patients, the improved one. We added autologous Platelet-Rich Plasma (hereinafter - PRP) to the muscle graft before placing it into the bone defect. After filling in the defect, we sutured a Resorbable Collagen Membrane (hereinafter - RCM) to its edges in order to seal the defect and additionally fix the muscle graft. The dynamics of changes in the structure and the rate of fixation of the muscle graft to the walls of the bone cavity, the duration of the local inflammatory response, the duration of hospitalization, short-term outcomes, and long-term results of treatment in the comparison groups were evaluated.