Anterior Tongue Cancer: Age Is Not a Predictor of Outcome and Should Not Alter Treatment

Veness, Michael J.; Morgan, Gary J.; Sathiyaseelan, Yasoda; Gebski, Val

doi:10.1046/j.1445-2197.2003.02818.x

Cited by 44 publications

(54 citation statements)

References 33 publications

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“…Age and gender did not influence the OS and DFS, similar to the observed in several studies (25-27). Tobacco and alcohol consumption also did not influence the outcome of these patients, as observed by Vallecillo-Capilla et al (13).…”

Section: Discussionsupporting

confidence: 90%

A clinical-pathological and survival study of oral squamous cell carcinomas from a population of the North of Portugal

Monteiro¹,

Amaral²,

Vizcaíno³

et al. 2014

Med Oral

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Objectives: Our aim was to analyze the clinical, pathological, and outcome characteristics of oral squamous cell carcinomas (OSCC) from a population of the north of Portugal. Material and Methods: We conducted a descriptive study of 128 OSCC diagnosed between the years of 2000 and 2010 in the Centro Hospitalar do Porto. Through of the review of the clinical records we studied several clinical, pathological, and outcome variables. The overall survival (OS) and disease-free survival (DFS) were analyzed by Kaplan-Meier method and log-rank test. Cox regression method was used for multivariate analysis. Results: Of 128 patients with OSCC, 83 (64.8%) were male and 45 (35.2%) were female, (mean age of 62.13±15.57 years). The most affected location was the tongue (n=52; 40.6%). The most common cause of reference was a non-healing ulcer (n=35; 28.9%) followed by oral pain (n=27; 22.3%). Sixty (60.6%) patients were tobacco consumers and 55 (57.3%) alcohol consumers. The cumulative 3-years OS rate was 58.6% and DFS was 55.4%. In multivariable analysis for OS, we found an adverse independent prognostic value for advanced tumour size (p<0.001) and for the presence of perineural permeation (p=0.012). For DFS, advanced stage tumours presented adverse independent prognostic value (p<0.001). Conclusions: OSCC occurred most frequently in males, in older patients, and in patients with tobacco and/or alcohol habits. TNM and tumour stage additionally to the perineural permeation were the most important prognostic factors for the survival of these patients, contributing to identify high-risk subgroups and to guide therapy. Key words:Squamous cell carcinoma, mouth neoplasms, oral cancer, oral pathology, prognosis.

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Section: Discussionsupporting

confidence: 90%

A clinical-pathological and survival study of oral squamous cell carcinomas from a population of the North of Portugal

Monteiro¹,

Amaral²,

Vizcaíno³

et al. 2014

Med Oral

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“…Veness et al (18) reported that the proportion of poorly-differentiated tumors in the young group was greater, however, Manuel et al (9) and Atula et al (15) reported that the majority of the tumors in their series were well-differentiated. In the present study, tumor differentiation was identified to be the most important prognostic factor for young patients and was found to significantly correlate with the RFS (P=0.016) and DSS (P=0.041) rates.…”

Section: Discussionmentioning

confidence: 98%

Tongue squamous cell carcinoma as a possible distinct entity in patients under 40 years old

et al. 2014

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Much controversy exists in the published literature regarding the clinical course and prognosis of tongue squamous cell carcinoma (SCC) in young patients. The aim of the current study was to evaluate the clinical results of tongue SCC in young patients. A total of 176 patients were included in this retrospective study. The patients were divided into two groups (young and old) according to an age cut-off of 40 years. The χ2 test and Kaplan-Meier method were used to analyze the variables. In total, 15 patients were <40 years old and placed into the young group, with five-year recurrence-free survival (RFS) and disease-specific survival (DSS) rates of 30 and 63%, respectively, compared with 47 and 62%, respectively, in the old group. No significant differences were identified between the RFS and DSS rates of the two groups, however, the young patients exhibited a different failure pattern. Overall, nine out of 10 recurrences in the young group occurred at a primary site compared with 18 out of 70 in the old group (P<0.001). Univariate analysis revealed that gender and differentiation were associated with recurrence and neck nodal involvement. In addition, poor differentiation was found to significantly decrease the DSS time. However, the prognosis of tongue SCC in the young patient group did not appear to differ from that of the old patient group. Furthermore, in the young patient group, local recurrence was the most common failure pattern and tumor differentiation was the most important prognostic factor.

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“…Most of the studies conducted to date on the potential prognostic significance of age in tongue cancer have yielded conflicting results 4–17 . This might be explained by the almost exclusive use of 40–45 years as the cut‐off for comparison, with a wide range of mean ages, from 30 to 38 years.…”

mentioning

confidence: 99%

ORIGINAL ARTICLE: Squamous cell carcinoma of the oral tongue in patients younger than 30 years: clinicopathologic features and outcome

Soudry

Preis

Hod

et al. 2010

Clinical Otolaryngology

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Anterior Tongue Cancer: Age Is Not a Predictor of Outcome and Should Not Alter Treatment

Abstract: In keeping with recently published evidence, young age at diagnosis with anterior tongue cancer did not portend worse outcome. There is therefore currently no strong evidence to support a different treatment approach in young patients.

Cited by 44 publications

References 33 publications

A clinical-pathological and survival study of oral squamous cell carcinomas from a population of the North of Portugal

A clinical-pathological and survival study of oral squamous cell carcinomas from a population of the North of Portugal

Tongue squamous cell carcinoma as a possible distinct entity in patients under 40 years old

ORIGINAL ARTICLE: Squamous cell carcinoma of the oral tongue in patients younger than 30 years: clinicopathologic features and outcome

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