Anterior Uveitis Due to Intracameral Moxifloxacin: A Case Report

Muñoz-Ortíz, Juliana; Reyes-Guanes, Juliana; de-la-Torre, Alejandra

doi:10.1080/09273948.2020.1757120

Cited by 12 publications

(5 citation statements)

References 14 publications

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“…10,13,14,19,23 However, there are more recent reports of unilateral BAIT-like cases following intracameral administration of moxifloxacin. 24,25,26,27,28 These reports support the notion that BAIT can be considered as an adverse ocular reaction of fluoroquinolone antibiotic use, primarily moxifloxacin. 29,30 Both BADI and BAIT patients may occasionally present with asymmetrical severity that can be misinterpreted as unilateral involvement.…”

Section: Unilateral Cases and Overlapping Cases Of Badi And Baitsupporting

confidence: 60%

Bilateral Acute Depigmentation of Iris (BADI) and Bilateral Acute Iris Transillumination (BAIT)-An Update

Tuğal-Tutkun¹,

Altan²

2022

tjo

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Clinical Features of BADI BADI was first described in 2006 by Tugal-Tutkun and Urgancioglu 1 in a series of 5 cases from Turkey. They described an acute episode of pigment discharge in the anterior chamber from the iris stroma, bilateral symmetrical diffuse or geographical areas of depigmentation and discoloration of the iris stroma, Krukenberg's spindles, and pigment deposition in the trabecular meshwork. In their subsequent series, Tugal-Tutkun et al. 3 described 26 new cases and long-term follow-up of 2 cases. Following these early publications, many cases have been reported from other countries. 4,5,6,7,8,9 BADI affects predominantly young females. It presents as a sudden-onset redness, ocular pain, tearing, and photophobia in both eyes simultaneously or within a few days of each other. Severe photophobia is the most prominent symptom. The patients usually maintain normal visual acuity. 1,3,4,5 Patients with BADI present with severe diffuse episcleral injection, more pronounced than ciliary injection. They do not have signs of intraocular inflammation, but they present with circulating pigment in the anterior chamber, which may

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Section: Unilateral Cases and Overlapping Cases Of Badi And Baitsupporting

confidence: 60%

Bilateral Acute Depigmentation of Iris (BADI) and Bilateral Acute Iris Transillumination (BAIT)-An Update

Tuğal-Tutkun¹,

Altan²

2022

tjo

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“…Several authors have reported the development of toxic anterior segment syndrome secondary to intracameral moxifloxacin. [ 6 7 8 9 10 ] However, FBA has never been reported following the use of this antibiotic. The repaired eye showed an exaggerated anterior segment inflammatory reaction on the first POD.…”

Section: Discussionmentioning

confidence: 99%

Frosted branch angiitis following corneal tear repair

Kohli

Babu

et al. 2022

Taiwan Journal of Ophthalmology

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We report a patient who developed frosted branch angiitis (FBA) and was diagnosed 1 month after the penetrating eye injury (PEI) repair. A 31-year-old male with no systemic comorbidities presented with defective vision following trauma to his left eye while cutting wood. His best-corrected visual acuity (BCVA) was 20/200. Anterior segment examinations showed a zone I full-thickness corneal tear with iris tissue incarceration. There was no clinical evidence of intraocular foreign body (IOFB) or endophthalmitis. He underwent PEI repair with iris abscission on the same day with intracameral moxifloxacin injection. His BCVA on postoperative day 45 was 20/200. Examination showed a resolving vitreous hemorrhage, venous tortuosity, and retinal perivascular infiltration affecting the venules from the posterior pole up to the periphery. He was treated with oral and topical steroids. The clinical signs resolved completely and BCVA improved to 20/20 after 1 month of treatment. FBA can complicate the recovery of eyes after PEI repair, even in the absence of endophthalmitis or sympathetic ophthalmia. A thorough search for IOFB or its tell-tale signs should be done in such eyes.

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“…Details of several cases of toxicity with intracameral moxifloxacin have been published this year [ 4 – 7 ]. All 4 of the cases in the series by Sanchez-Sanchez et al occurred after glaucoma surgery in which patients received Vigamox brand moxifloxacin intracamerally and subconjunctival mitomycin C [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the two cases associated with cataract surgery, one involved Vigamox brand moxifloxacin [ 6 ]. In the other case by Peñaranda-Henao et al, it was unknown what dose or brand of moxifloxacin was used as the surgery had been performed at an outside institution [ 7 ]. It is also unknown whether any other intraocular medications were administered in either of these cases, but 1% preservative-free lidocaine is commonly given intracamerally during cataract surgery.…”

Section: Discussionmentioning

confidence: 99%

Toxic Anterior Segment Syndrome with Intracameral Moxifloxacin: Case Report and Review of the Literature

Amireskandari

Bean

Mauger

2021

Case Reports in Ophthalmological Medicine

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A case of severe anterior segment toxicity secondary to high-volume, undiluted intracameral moxifloxacin for endophthalmitis prophylaxis is reported. We examine the other reported cases of toxicity after intracameral moxifloxacin, as well as iris depigmentation and transillumination syndromes after oral and topical fluoroquinolone exposure. Additionally, we review the literature on safety, efficacy, and appropriate dosing of intracameral antibiotics with a focus on moxifloxacin.

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Anterior Uveitis Due to Intracameral Moxifloxacin: A Case Report

Cited by 12 publications

References 14 publications

Bilateral Acute Depigmentation of Iris (BADI) and Bilateral Acute Iris Transillumination (BAIT)-An Update

Bilateral Acute Depigmentation of Iris (BADI) and Bilateral Acute Iris Transillumination (BAIT)-An Update

Frosted branch angiitis following corneal tear repair

Toxic Anterior Segment Syndrome with Intracameral Moxifloxacin: Case Report and Review of the Literature

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