Anterograde labeling of the corticospinal tract in jimpy mutant mice by Di I injection into the motor cortex

Shibata-Iwasaki, Riichi; Dekimoto, Hideyuki; Katsuyama, Yu; Kikkawa, Satoshi; Terashima, Toshio

doi:10.1679/aohc.70.297

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Firstly, the axons of the γ motor neurons are thin and non-myelinated. Secondly, the specific effects of neutrophic factors are not yet proven on the neurons [47]. Supplementary observation of associated changes of sensory neurons in spinal ganglia is necessary.…”

Section: α γmentioning

confidence: 99%

Morphological and Electromyogram Analysis for the Spinal Accessory Nerve Transfer to the Suprascapular Nerve in Rats

Jing¹,

Ogino²,

Hitomi³

2011

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For many years, nerve transfer has been commonly used as a treatment option following peripheral nerve injury, although the precise mechanism underlying successful nerve transfer is not yet clear. We developed an animal model to investigate the mechanism underlying nerve transfer between branches of the spinal accessory nerve (Ac) and suprascapular nerve (Ss) in rats, so that we could observe changes in the number of motor neurons, investigate the 3-dimensional localization of neurons in the anterior horn of the spinal cord, and perform an electromyogram (EMG) of the supraspinatus muscle before and after nerve transfer treatment. The present experiment showed a clear reduction in the number of γ motor neurons. The distributional portion of motor neurons following nerve transfer was mainly within the neuron column innervating the trapezius. Some neurons innervating the supraspinatus muscle also survived post-transfer. Compared with the non-operated group, the EMG restoration rate of the supraspinatus muscle following nerve transfer was 60% in the experimental group and 80% in a surgical control group. Following nerve transfer, there was a distinct reduction in the number of γ motor neurons. Therefore, γ motor neurons may have important effects on the recovery of muscular strength following nerve transfer. Moreover, because the neurons located in regions innervating either the trapezius or supraspinatus muscle were labeled after Ac transfer to Ss, we also suggest that indistinct axon regeneration mechanisms exist in the spinal cord following peripheral nerve transfer.

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Section: α γmentioning

confidence: 99%

Morphological and Electromyogram Analysis for the Spinal Accessory Nerve Transfer to the Suprascapular Nerve in Rats

Jing¹,

Ogino²,

Hitomi³

2011

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Anterograde Axonal Tract Tracing

Wang

Deng

2012

Springer Protocols Handbooks

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Afferent and Efferent Connections of the Pineal Organ in the European Sea Bass <i>Dicentrarchus labrax:</i> A Carbocyanine Dye Tract-Tracing Study

Servili

Herrera-Pérez²,

Yáñez³

et al. 2011

Brain Behav Evol

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The pineal organ of fish is a photosensitive structure that receives light information from the environment and transduces it into hormonal (rhythmic melatonin secretion) and neural (efferent projections/neurotransmitters) signals. In this study, we focused on this neural output. Thus, we performed a tract-tracing study using 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI), a fluorescent carbocyanine dye, in order to elucidate the efferent and afferent connections of the pineal organ in the European sea bass. The axonal transport of DiI revealed extensive bilateral projections in the sea bass brain. The efferent projections of the sea bass pineal organ reach the habenula, ventral thalamus, periventricular pretectum, central pretectal area, posterior tubercle and medial and dorsal tegmental areas. In addition, in this study we also examined the pinealopetal system in sea bass. This analysis demonstrated that the sea bass pineal organ receives central projections from neurons located, to a large extent, in brain areas innervated by pineal efferent projections, i.e. the thalamic eminence, habenula, ventral thalamus, dorsal thalamus, periventricular pretectum, posterior commissure, posterior tubercle and medial tegmental area. This study is the first description of pinealofugal projections in a representative of Perciformes, which constitutes a derived order within teleosts. Moreover, it represents the first evidence for the presence of pinealopetal neurons in the brain of a teleost species. Our findings, together with the analysis of retinal connections, represent a step forward in the understanding of the integration of photoperiodic signals into the central nervous system of sea bass.

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Anterograde labeling of the corticospinal tract in jimpy mutant mice by Di I injection into the motor cortex

Cited by 4 publications

References 14 publications

Morphological and Electromyogram Analysis for the Spinal Accessory Nerve Transfer to the Suprascapular Nerve in Rats

Morphological and Electromyogram Analysis for the Spinal Accessory Nerve Transfer to the Suprascapular Nerve in Rats

Anterograde Axonal Tract Tracing

Afferent and Efferent Connections of the Pineal Organ in the European Sea Bass <i>Dicentrarchus labrax:</i> A Carbocyanine Dye Tract-Tracing Study

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