Anthelminthic medicinal plants in veterinary ethnopharmacology: A network meta-analysis following the PRISMA-P and PROSPERO recommendations

Abstract

Medicinal plants may be effective against helminthic infestation in animals, but to date few studies have investigated the real impact of anthelminthic medicinal plants in veterinary ethnopharmacology.The aim of this study was to assess the geographical use of anthelminthic medicinal plants in livestock in European Union (EU), and to quantify the anthelminthic efficacy of medicinal plants in comparison with anthelminthic drugs. Surveys on the use of anthelminthic traditional medicinal plants in livestock in the EU were included in the qualitative synthesis. Studies that investigated the efficacy of anthelminthic traditional medicinal plants in animals, compared with negative control and/or anthelminthic drugs, were included in the quantitative synthesis (network meta-analysis).Twelve surveys (9 in Italy, 2 in Spain, 1 in Austria) reported the use of anthelminthic medicinal plants in livestock living in EU Countries. Data obtained from 256 animals and extracted from 6 studies were included in the network meta-analysis. Medicinal plants and drugs were more effective than negative control (standardized mean difference [SMD]: -0.60 95%CrI -0.88 to -0.31, -0.73 95%CrI -1.08 to -0.38, respectively, P < 0.001). Overall, no difference was detected between anthelminthic medicinal plants and anthelminthic drugs, namely albendazole, ivermectin, fenbendazole, and doramectin (SMD: 0.26 95%CrI -0.02 to 0.55, P > 0.05). The most effective anthelminthic medicinal plants were Artemisia absintihium, Allium sativum, and Duranta erecta.There is the strong medical need of performing adequately powered randomized controlled trials in different livestock species aimed to improve the quality of the current evidence concerning the anthelminthic efficacy of medicinal plants compared to that of the currently available antiparasitic drugs.

Green Veterinary Pharmacology Applied to Parasite Control: Evaluation of Punica granatum, Artemisia campestris, Salix caprea Aqueous Macerates against Gastrointestinal Nematodes of Sheep

“…In Europe, a relevant number of plants are used to treat organic livestock [ 20 ]. Also, in Italy, many plants were used to treat cattle, sheep, poultry, horses, and pigs [ 49 ] and some of these plants may be effective against helminth infections in animals [ 50 ].…”

A meta-analysis of Geogebra software decade of assisted mathematics learning: what to learn and where to go?

“…Cover this gap, and efforts must be made to integrate primary findings to provide useful information for policymaking ( Higgins and Katsipataki, 2015 ; Siddaway et al., 2019 ). For this reason, a meta-analysis study is needed, which includes all the primary studies on the subjects mentioned above, to provide more generalizable findings compared to the primary study ( Demirel and Dağyar, 2016 ; Calzetta et al., 2020 ). However, in the literature, there has not been a meta-analysis study that assesses the effectiveness of mathematics learning supported by GeoGebra software's use on students' mathematical abilities.…”

In Vitro Anthelminthic Efficacy of Aqueous Pomegranate (Punica granatum L.) Extracts against Gastrointestinal Nematodes of Sheep

“…In many countries of the world, in particular in Asia and Africa [ 12 , 13 , 14 ] and in some European countries [ 15 ], plants have been used in local traditions for parasite control in small ruminants. These traditions have survived in some area of Italy [ 16 , 17 ], in particular in southern regions [ 18 , 19 ], where some aqueous plant-based macerates, including pomegranate ( Punica granatum L.), are used by several farmers and pastoralists.…”