Anthelmintic activity of acetone–water extracts against Haemonchus contortus eggs: Interactions between tannins and other plant secondary compounds

Vargas-Magaña, J.J.; Torres-Acosta, J.F.J.; Aguilar-Caballero, A.J.; Sandoval-Castro, C.A.; Hoste, Hervé; Chan-Pérez, José Israel

doi:10.1016/j.vetpar.2014.10.008

Cited by 100 publications

(93 citation statements)

References 22 publications

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“…Previously, it was suggested that tannins and saponins possibly penetrated the egg affecting the morula [22] and stop hatching [23] of H. contortus eggs.…”

Section: Discussionmentioning

confidence: 99%

Comparative ovicidal activity of Moringa oleifera leaf extracts on Fasciola gigantica eggs

Hegazı¹,

Megeed²,

Hassan³

et al. 2018

Vet World

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Background:Fasciolosis is an important zoonotic disease affecting the productive performance of farm animals in Egypt.Aim:The aim of the present study was comparing the ovicidal effect of different extracts as an alcoholic (Methanolic and Ethanolic) and aqueous Moringa oleifera leaf extracts on Fasciola gigantica non-embryonated and developed eggs.Materials and Methods:Tested concentrations of extracts ranged from 12.5 to 800 mg/ml. Nitroxynil was used as reference drug with a dose of 100 mg/ml.Results:M. oleifera alcoholic and aqueous extracts showed a concentration-dependent ovicidal effect on F. gigantica non-embryonated and developed eggs. Based on LC50 values, water extract showed the highest ovicidal activity since it registered the lowest values of 2.6 mg/ml on non-embryonated eggs. Non-embryonated eggs were more susceptible to aqueous extract than developed eggs. On the other hand, the developed eggs were more susceptible to ethanolic extract than non-embryonated eggs even the lowest LC50 (12.38 mg/ml).Conclusion:M. oleifera leaf extracts especially aqueous extract could be a promising step in the field of controlling fascioliasis. Further, in vivo studies are needed to enlighten the therapeutic potential of M. oleifera extracts in treating F. gigantica infection.

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“…Previously, it was suggested that tannins and saponins possibly penetrated the egg affecting the morula [22] and stop hatching [23] of H. contortus eggs.…”

Section: Discussionmentioning

confidence: 99%

Comparative ovicidal activity of Moringa oleifera leaf extracts on Fasciola gigantica eggs

Hegazı¹,

Megeed²,

Hassan³

et al. 2018

Vet World

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“…The purpose is to assess the ability of the target extract to prevent or impede the hatching of larvae from the eggs after contact with it. This can be achieved by interrupting the blastular development of the nematode embryo [16] , blockage of the enzymatic pathways or interference in the action of enzymes associated with hatching [33] . The larval migration inhibition test (LMIT) [34] is used to evaluate the resistance to anthelmintics that act either to stimulate or inhibit the somatic musculature.…”

Section: In Vitro Methods To Evaluate Anthelmintic Plant Substancesmentioning

confidence: 99%

“…On the other hand, negative (antagonistic) interactions can also occur. Polyphenol compounds of Lysiloma latisiliquum (L.) Benth and Theobroma cacao (Linnaeus) were implicated in reducing the anthelmintic activity of acetone: water extracts of two plants on H. contortus eggs, as shown by the increase of the nematicidal effect after incubation of the extracts with polyvinyl polypyrrolidone, an inhibitor of polyphenols [33] .…”

Section: Compounds Of Plant Origin With Anthelmintic Actionmentioning

confidence: 99%

Plants and their medicinal potential for controling gastrointestinal nematodes in ruminants

Borges¹,

Borges²

2016

Nematoda

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HIGHLIGHTS• Plants with anthelmintic activity may have potential sources of chemical substances that can be used to control gastrointestinal nematodes in ruminants.• The main difficulty of the research with herbal medicines is the lack of in vitro and in vivo correlation with phytotherapic substances activities.• Better understanding the interactions between metabolites and the use of appropriate methodologies to evaluate phytotherapics, may contribute to in vivo results. ABSTRACT:Gastrointestinal nematodes (GINs) is one of the main sanitary problems of ruminant herds, causing large economic losses to breeders. Chemical control continues to be the main measure used to combat GINs, but as resistant parasite populations spread, the efficiency of this method is becoming impaired. In light of this situation, alternative ways to control verminosis are gaining importance. Among these, phytotherapy has attracted particular attention. This review presents the current status of research on phytotherapeutic agents, their difficulties and perspectives. Plants with nematicidal activity are a potential source of chemical substances, including new molecules, that can be used to control GINs in ruminants. The principal difficulty of research into phytotherapic substances is to identify the bioactive compounds, because in many cases in vitro tests have shown promising results, but in vivo test results have been disappointing. Among the causes is host-drug interaction. Therefore, more careful choice of plants with anthelmintic potential by adoption of a standardized system to analyze the results of in vitro testing, combined with better understanding of the synergistic relations among metabolites and the adjustment of methods for in vivo testing, can make phytotherapy for control of GINs more effective.

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“…La exploración de plantas para el control de nemátodos gastrointestinales de ovejas y cabras ha sido extensa en los últimos diez años, lo que ha desarrollado el uso de extractos crudos o soluciones antiparasitarias. Entre las plantas investigadas con efecto ovicida y larvicida contra H. contortus, se reporta Theobroma cacao (Vargas-Magaña et al 2014), Citrus sinensis (Islam et al 2015), Artemisia vestita, Artemisia maritima (Irum et al 2015) y Rhizophora mangle (Alemán et al 2011 Se tuvieron cinco repeticiones para cada concentración y testigos. Las microplacas se sellaron y se mantuvieron por 24 h en incubadora a 27…”

Section: Luck-montero Et Al Actividad Antihelmíntica De Extractos Acunclassified

Actividad ovicida y larvicida de extractos acuosos de Pluchea sericea y Artemisia tridentata en Haemonchus contortus

Montero¹,

Reyes²,

Aíl-Catzim³

et al. 2018

Ecosist. Recur. Agropec.

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El objetivo fue evaluar la actividad ovicida y larvicida de extractos acuosos de hojas de Pluchea sericea y Artemisia tridentata sobre Haemonchus contortus. Se evaluaron concentraciones de 100, 75, 50, 25 y 12.5 mg mL-1 de cada extracto. Se tuvo diferencias signicativas (p 0.05) para todas las concentraciones en la inhibición de la eclosión de huevos y mortalidad larval de H. contortus. La dosis de 100 mg mL-1 redujo la eclosión larvaria en 100 y 96.30%, con mortalidad larvaria del 92.67 y 89.33% para P. sericea y A. tridentata, respectivamente. La CL50 fue de 23.21 y 23.26 mg mL-1 para la inhibición de eclosión de huevos, para la mortalidad larvaria se tuvo una CL50 de 20.36 y 27.18 mg mL-1 para los extractos de P. sericea y A.tridentata, respectivamente. Los extractos acuosos de hojas de P. sericea y A. tridentata controlan los estadios de huevo y larva de H. contortus.

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Anthelmintic activity of acetone–water extracts against Haemonchus contortus eggs: Interactions between tannins and other plant secondary compounds

Cited by 100 publications

References 22 publications

Comparative ovicidal activity of Moringa oleifera leaf extracts on Fasciola gigantica eggs

Comparative ovicidal activity of Moringa oleifera leaf extracts on Fasciola gigantica eggs

Plants and their medicinal potential for controling gastrointestinal nematodes in ruminants

Actividad ovicida y larvicida de extractos acuosos de Pluchea sericea y Artemisia tridentata en Haemonchus contortus

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