Anthelmintic Activity of Methanolic Leaf Extract of Sophora Interrupta

Hemamalini, K.; Rajani, A.; Vasireddy, Uma; sundari, E Ratna

doi:10.7897/2230-8407.04828

Cited by 9 publications

(7 citation statements)

References 6 publications

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“…The presence of saponins in the crude as saponins is known cause parallel irritation of mucus membrane which could lead to death of the parasite [13]. Phenols also the ability to form phenolic complexes capable of interfacing with energy generation in helminth parasite thereby by causing uncoupling oxidative phosphorylation that directly affects energy generation in the helminth parasite [14].…”

Section: Resultsmentioning

confidence: 99%

“…This is indeed obvious because the Table 5. subsequent bonding between C (14) and C (15) Table 5. Similarly consistent with this tabulated result is the bonding pattern on the other side of the double bond towards the COOH where C(8) δ C 128.85 and δ H 5.342 is bonded to methylenic C(7) δ C 34.06 and δ H 2.321, further bonding of C(7) to methylenic C(6) at δ C 29.65 and δ H 1.303 is followed by bonding to methylenic C(5),C(4), C(3), and C(2) as shown on Table 5.…”

Section: Structural Elucidation and Results Discussion (Compound A)mentioning

confidence: 99%

“…The presence of a carboxylic acid group (COOH) at positions C(14) (γ and δ to C(13) and C(12) respectively) alters the C=C Chemical shift to 129.1ppm and 134.1ppm for C (12) and C(13) respectively e.g. quinovic acid [14]. According to the author [14] 'Except for those cases with COOH substituent in close proximity to a C(12)=C(13) bond, the chemical shifts of C (12) and C(13) are 125 ppm and 138 ppm respectively as in ursolic acid.…”

Section: Structural Elucidation Of Compound Bmentioning

confidence: 99%

“…quinovic acid [14]. According to the author [14] 'Except for those cases with COOH substituent in close proximity to a C(12)=C(13) bond, the chemical shifts of C (12) and C(13) are 125 ppm and 138 ppm respectively as in ursolic acid. The spectral data for GC-MS, IR and NMR proved that the compound is 3-Hydroxyurs-12-en-28-oic acid.…”

Section: Structural Elucidation Of Compound Bmentioning

confidence: 99%

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Anthelmintic Activities of Hexacosa-9, 11-dienoic Acid and 3-hydroxyurs-12-en-28-oic Acid Isolated from Spermacoce verticillata

Garba

Adeyemi

Musa

2019

CSIJ

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The phytochemical screening, anthelmintics, and characterization of Spermacoce verticillata crude ethanolic extracts were carried out using standard methods. The research is aimed at investigating the in-vitro anthelmintic activity of Spermacoce verticillata and Cochlospermum tinctorium plants for possible active components. The results of phytochemical screening showed the presence of Alkaloids, Flavonoids, Tannin, Phenol, Fatty acid and Cardiac glycoside, Terpenoid and Saponin. The result of the anthelmintic activities showed that Spermacoce verticillata have paralysis time ranging from 25.9 -71.6 mins with death times ranging from 39 - 90.1 mins at concentrations range between 25 - 100 mg/cm3 The results of Chromatographic and Spectroscopic Analyses using TLC, CCH, IR, NMR GC-MS of c leads to the Isolation of two compounds namely Hexacosa-9,11-dienoic acid (fatty acid) and 3-hydroxyurs-12-en-28-oic acid (Pentacyclic triterpenoid) with paralysis/death time at concentration of 50 mg/cm3 of 22.5 mins and 36.3 mins for the fatty acid and 13.2 mins and 20.1 mins for the pentacyclic triterpenoid. The results were compared with standard drug (Albendazole) which showed higher activity than the crude extracts but lower than the isolated compounds. The results of this work therefore confirmed the traditional claim of using the plant for the treatment of helminthiasis disease.

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Section: Resultsmentioning

confidence: 99%

Section: Structural Elucidation and Results Discussion (Compound A)mentioning

confidence: 99%

Section: Structural Elucidation Of Compound Bmentioning

confidence: 99%

Section: Structural Elucidation Of Compound Bmentioning

confidence: 99%

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Anthelmintic Activities of Hexacosa-9, 11-dienoic Acid and 3-hydroxyurs-12-en-28-oic Acid Isolated from Spermacoce verticillata

Garba

Adeyemi

Musa

2019

CSIJ

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“…At the concentration of 5mg/ml ,10mg/ml, 20mg/ml ,25mg/ml 30mg/ml. [15] Albendazole was used as a standard drug to compare the test. The methanolic leaf extract showed significant activity.…”

Section: Figure 13: Seeds Of Trachyspermum Ammimentioning

confidence: 99%

In Vitro Anthelminitic Activity of Medicinal Plants -A Review

Kumari¹,

Mridhula²,

Kanimozhi³

et al. 2019

AJPTR

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The present review deals with medicinal plants having anthelminitic activity widely distributed worldwide. Medicinal plants or medicinal herbs are essence of traditional practice. Anthelmisintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Several preventive and corrective methods for modern medicine are available, however, it is not safe due to serious side effects .In order to overcome these side effects, there is a need of natural anthelminitic agents with minimal side effects. In ancient and modern pharmacology period, several number of medicinal plants having anti-anthelmintic efficacy. This review article gives the list of medicinal plants having anthelminitic activity.

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