Anthelmintic efficacy of crude neem (Azadirachta indica) leaf powder against bovine strongylosis

Jamra, Nirmala; Das, G.; Singh, Priyanka; Haque, Mazhar

doi:10.1007/s12639-014-0423-9

Cited by 16 publications

(12 citation statements)

References 9 publications

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“…The calculation of the dose of A. indica infusion was referred to Beriajaya & Haryuningtyas (2005) by observing the average values of abomasum fluid. Meanwhile, albendazole was given to group D as a single oral dose (Jamra et al, 2014). The experimental ewes were fed with Penissetum hybrid and wheat bran provided with water ad lib.…”

Section: In Vivo Anthelmintic Testmentioning

confidence: 99%

In Vitro and in Vivo Anthelmintic Activities of Aqueous Leaf Infusion of Azadirachta indica against Haemonchus contortus

Sakti

Kustantinah

Nurcahyo

2018

Trop. Anim. Sci. J.

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Anthelmintic resistance of Haemonchus contortus worm has become a major problem in ruminant production. Traditional medicinal and potential tropical plants with high tannin contents have a great potency as an alternative source of bio-anthelmintic. The study was carried out to assess the in vitro egg hatches inhibiting (EHI) and adult worm motility (AWM) tests and in vivo anthelmintic activities of aqueous leaf infusion of Azadirachta indica against H. contortus. Leaf infusion at doses of 2%, 4%, and 6% were used for in vitro treatments, and albendazole at a dose of 2 mg/mL was used as a positive control and 0.9% of sodium chloride was used as a negative control. The EHI assay was conducted two times i.e., before treatment and 24 h after treatment. The AWM were monitored 15 and 30 min, and 1, 2, 3, 4, 5, 6, 7, and 8 h post treatment. Sixteen Javanese Thin Tail ewes at the ages of ±12 months that naturally positive of H. contortus with about 1.000 EPG were selected and allocated randomly to 4 groups (n= 4). They were subsequently received the ensuing treatments i.e., A. indica infusion at doses of 0% (A) as a control, 6% (B), 8% (C), and 5 mg/BW albendazole (D) at a single oral dose as a positive control. Experimental ewes in Groups B and C were given oral infusion weekly during 4 weeks of treatment. EPG's fecal examinations were conducted weekly. The result showed that the leaf infusion of A. indica containing condensed tannin (CT) at a dose of 6% significantly inhibited egg hatching (P<0.05) with a better effect compared to doses of 0%, 2%, and 4%. In AWM test, three doses of infusion significantly difference each other, as well as both negative and positive controls (P<0.05). After treatment, both of the A. indica containing CT levels and albendazole reduced EPG count significantly (P<0.05). Meanwhile, significant difference was not detected in dose of 8% aqueous leaf infusion of A. indica and albendazole treatments on weeks 3, 4, 5, and 6 consecutively. In conclusion, the aqueous leaf infusion of A. indica is fully potential as a bio anthelmintic against H. contortus.

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Section: In Vivo Anthelmintic Testmentioning

confidence: 99%

In Vitro and in Vivo Anthelmintic Activities of Aqueous Leaf Infusion of Azadirachta indica against Haemonchus contortus

Sakti

Kustantinah

Nurcahyo

2018

Trop. Anim. Sci. J.

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“…This plant is indigenous to South Asia and abundant in the tropical belt [6]. The plant has been reported to have anti-hyperglycaemic, antibacterial [7], antifungal, anthelmintic [8], antioxidant, anti-inflammatory and antimalarial [9] activities. The plant has been reported to contain diterpenoids, triterpenoids, alkaloids, flavonoids and phenolic compounds [10].…”

Section: Introductionmentioning

confidence: 99%

In vivo Antimalarial Activities of Five Ugandan Medicinal Plants on Plasmodium berghei in Mice

Ajayi

Elujoba

Okella

et al. 2020

EJMP

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Aim: Medicinal plants have played an important role in the treatment of different ailments including malaria in developing countries particularly in Africa. This study has evaluated the antimalarial activities of Azadirachta indica A. Juss (Meliaceae), Cymbopogon citratus Stapf. (Poaceae), Moringa oleifera Lam. (Moringaceae), Tithonia diversifolia (Hemsl) A. Grey (Asteraceae) and Vernonia amygdalina Del. (Asteraceae) which are commonly-used for malaria treatment in Uganda. Study Design: This is an experimental laboratory report on antimalarial activities of some Ugandan medicinal plants for subsequent profiling in an herbal pharmacopoeia and eventual drug development. Place and Duration of Study: The Animal Research Facility and the Clinical and Research Laboratory, Faculty of Medicine, Mbarara University of Science and Technology, Uganda, between July 2019 and March 2020. Methodology: The antimalarial activity of the hot infusion of each leaf was evaluated on chloroquine-sensitive Plasmodium berghei ANKA-infected mice using 4-day test at 100 – 400 mg/kg with chloroquine (10 mg/kg) and artemether-lumefantrine (4 mg/kg) as positive controls; and distilled water as negative control. The observed haematological responses of the animals were determined with an automated haematometer. Results: The results showed dose-dependent activities in the animals treated with the extract of each plant leaf in varying degrees. Thus, V. amygdalina and T. diversifolia showed the highest antimalarial activities with the chemosuppression values of 75% and 66% at 400 mg/kg, respectively. The results of V. amygdalina, T. diversifolia and M. oleifera, extracts gave the lowest ED50 of 141, 195 and 231 mg/kg, respectively being significantly different from A. indica (ED50 319 mg/kg) and C. citratus (ED50 346 mg/kg) with V. amygdalina as the most potent extract among the five plant leaves. Conclusion: The observed activities of the five plants have therefore supported their folkloric uses as antimalarial remedies by the Ugandan traditional medicine practitioners with obvious potentials for drug development.

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“…Further, Biswas et al (2002) reviewed that many bioactive compounds in neem leaf were cyclic-trisulphide and cyclic tetrasulphide which it can be used antivirus, antiparasite and support to humoral immunity. Neem leaf had also been reported as an ethnoveterinery medicine for inhibiting larvae of the sheep nose bot fly (Cepeda-Palacios et al 2014) and preventing bovine strongylosis (Jamra et al 2015).…”

Section: Introductionmentioning

confidence: 99%

In vitro gas production kinetics and digestibility of king grass (Pennisetum hybrid) added by organic mineral and natural crude tannin

Sofyan

Sakti

Herdian

et al. 2016

Journal of Applied Animal Research

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Anthelmintic efficacy of crude neem (Azadirachta indica) leaf powder against bovine strongylosis

Cited by 16 publications

References 9 publications

In Vitro and in Vivo Anthelmintic Activities of Aqueous Leaf Infusion of Azadirachta indica against Haemonchus contortus

In Vitro and in Vivo Anthelmintic Activities of Aqueous Leaf Infusion of Azadirachta indica against Haemonchus contortus

In vivo Antimalarial Activities of Five Ugandan Medicinal Plants on Plasmodium berghei in Mice

In vitro gas production kinetics and digestibility of king grass (Pennisetum hybrid) added by organic mineral and natural crude tannin

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