Anthelmintic Efficacy of Milbemycin Oxime against Trichuris vulpis in Dogs.

Horii, Yoichiro; Otsuka, Yasuhiro; Tateishi, Mika; Makimura, Susumu; Kusano, Kenichi

doi:10.1292/jvms.60.271

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…The efficacy of milbemycin oxime in the removal of whipworms from naturally infected dogs has shown to be ~96-99% [73,74]. This molecule is licensed as an oral formulation for treating and controlling whipworms, roundworms and hookworms, reducing the level of infection by A. vasorum , preventing disease by D. immitis and, in some EU countries, controlling some canine mites.…”

Section: Treatment and Control: What Can We Actually Do To Tackle Whimentioning

confidence: 99%

Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis?

2011

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Trichuris vulpis, the dog whipworm, causes an intestinal parasitosis of relevance in current canine veterinary practice. Its occurrence is well-known in pets, kennelled dogs and stray animals, and its eggs contaminate the ground in urban areas all over the world. Moreover, T. vulpis has been occasionally incriminated, though not convincingly substantiated, as a cause of zoonosis. This nematode is erroneously considered an "old-fashioned" pathogen with a consequent lack of up- to- date knowledge on several aspects of the infection. These, in turn, are still controversial and need to be studied in greater depth. This article reviews current knowledge of T. vulpis, together with a discussion of critical points in epidemiology, zoonotic hazard, diagnosis and treatment of canine trichurosis.

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Section: Treatment and Control: What Can We Actually Do To Tackle Whimentioning

confidence: 99%

Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis?

2011

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“…The importance of modern heartworm, flea, and tick preventatives to the veterinary practitioner is as much in their ability to control endoparasites as to prevent clinical heartworm disease (Clark et al, 1992; Nolan et al, 1992; Horii et al, 1998; McTier et al, 2000). Given the zoonotic potential and high prevalence of many commonly identified parasites species, the Companion Animal Parasite council now advocates the use of such broad-spectrum heartworm preventatives as part of comprehensive parasite control programs (Blagburn et al, 1996; DeSantis et al, 2006; Schantz, 1994, 2003).…”

Section: Introductionmentioning

confidence: 99%

Factors influencing heartworm, flea, and tick preventative use in patients presenting to a veterinary teaching hospital

Gates

Nolan

2010

Preventive Veterinary Medicine

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The introduction of modern heartworm, flea, and tick preventatives has provided a safe and effective means of controlling companion animal endoparasites, but achieving good owner compliance remains an ongoing challenge for the veterinary profession. Based on a sample of patients from the veterinary teaching hospital at the University of Pennsylvania, this study retrospectively examined factors associated with preventative use and areas of potential weakness in client communication.Between 1999 and 2006, records of 5,276 canine and 1,226 feline patients were searched for signalment, survey results for heartworm, flea, and tick preventative use, date of visit, presenting complaint, vaccination history, and owner zip code. Data were analyzed using bivariate and multivariate techniques. Overall, only 13 -23 % of patients were questioned about heartworm, flea, or tick preventative use during routine medical history taking. Patients with a prior history of parasites, younger patients, or those presenting with signs of cardiac disease were no more likely to be questioned about preventative use than healthy animals. Patients presenting to a specialty service were also less likely to be questioned. Approximately 74 -79% of dogs and 12 -38 % of cats in the sample were on preventative products at any given time. There was a distinct seasonality to preventative use corresponding to the heartworm transmission season from June through November in the northeastern United States. Only 50% of patients seen for a yearly physical examination in winter were reported to be using preventative products when surveyed later in the year, compared to the roughly 85% on patients in heartworm preventatives when they received their routine physical exam in spring. Month of presentation and neuter status were the only signalment factors significantly (P<0.05) associated with preventative use in the multivariate analysis. Findings from this study emphasize target areas for increasing owner compliance.

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“…Fortunately, the introduction of monthly heartworm preventatives has provided veterinarians with another safe and theoretically effective tool for concurrently targeting nematode endoparasites. The active ingredients of products such as Heartgard Plus Ò (Ivermectin, pyrantel pamoate; Merial, Duluth, GA, USA), Revolution Ò (Selamectin; Pfizer, Animal Health, Kalamazoo, MI, USA), Interceptor Ò (Milbemycin oxime; Novartis, Animal Health, Greensboro, NC, USA), ProHeart Ò (Moxidectin; Fort Dodge, Animal Health, Overland Park, KS, USA), and Sentinel Ò (Milbemycin oxime, lufenuron; Novartis, Animal Health, Greensboro, NC, USA), have documented efficacy against ascarids and hookworms in laboratory studies (Clark et al, 1992;Nolan et al, 1992;Horii et al, 1998;McTier et al, 2000). However, the efficacy of these products in the field, where other factors such as owner compliance, inadequate dosing, and re-exposure can have a significant influence, is still largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of heartworm preventatives against ascarids and hookworms in client‐owned dogs: a retrospective case control study

Gates

Nolan

2011

Vet Pharm & Therapeutics

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The efficacy of heartworm preventatives against ascarids and hookworms was assessed in a retrospective analysis of 1329 dogs that received a fecal examination and were surveyed about heartworm preventative use upon presentation to the veterinary teaching hospital at the University of Pennsylvania. To remove confounding due to age, patients under 6 months old were analyzed separately from the remaining population. Although there were no reported cases of ascarids or hookworms in patients under 6 months old receiving monthly heartworm prevention, the prevalence reached 5.2% and 11.7%, respectively, in patients that were not using any products. For patients over 6 months old, there were no apparent associations between parasites and heartworm preventative use. Of the 75.5% of dogs that were administered heartworm preventatives, 16.1% reported seasonal use and 83.9% reported using the products year round. Patients using heartworm preventatives seasonally were no more likely to be harboring nematode parasites than patients using preventatives year round (OR = 0.70, 95% CI: 0.19-2.55). Overall efficacy rates were consistent with prior studies on the active ingredients. Heartworm preventative have the greatest value for controlling nematode endoparasites in patients under 6 months old.

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Anthelmintic Efficacy of Milbemycin Oxime against Trichuris vulpis in Dogs.

Cited by 6 publications

References 7 publications

Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis?

Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis?

Factors influencing heartworm, flea, and tick preventative use in patients presenting to a veterinary teaching hospital

Efficacy of heartworm preventatives against ascarids and hookworms in client‐owned dogs: a retrospective case control study

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