Anthelmintic resistance of gastrointestinal nematodes in goats: A systematic review and meta-analysis

Baudinette, Emily; O’Handley, Ryan; Trengove, Colin

doi:10.1016/j.vetpar.2022.109809

Cited by 12 publications

(10 citation statements)

References 107 publications

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“…Ivermectin resistance is a severe problem regarding nematodes of ruminants in many geographic regions and the problem is considered a substantial threat for animal health and productivity worldwide [40]. While evidence of ivermectin resistance in sheep and goat parasites is widespread in commercial breeding systems [41], only a limited number of reports are available from Africa [42, 43].…”

Section: Discussionmentioning

confidence: 99%

First evaluation and detection of ivermectin resistance in gastrointestinal nematodes of sheep and goats in South Darfur, Sudan

Mohammedsalih,

Ibrahim,

Juma

et al. 2024

Preprint

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In Sudan, resistance to benzimidazoles has been reported recently in cattle and goats from South Darfur. Herein, ivermectin efficacy against gastrointestinal nematodes (GINs) was evaluated in sheep and goats in three study areas in South Darfur. The faecal egg count reduction test (FECRT) was used to evaluate the efficacy of ivermectin in sheep and goats naturally infected with GINs in the region of Bulbul (goats: n=106), Kass (goats: n=40) and Nyala (Domaia (sheep: n=47, goats: n=77) and the University farm (goats: n=52)), using different treatment plans, and the efficacy was evaluated 12 days after treatment. Ivermectin efficacy was also evaluated in goats experimentally infected using local Haemonchus contortus isolates from Kass and Nyala. Nematodes surviving ivermectin treatment in goats in Bulbul and Nyala were harvested and larvae used to infect worm-free male sheep (n=6, ≤ 6 months old). Infected sheep were dosed subcutaneously with ivermectin every eight days with increasing doses from 0.2 mg/kg to 1.6 mg/kg bodyweight (bw). Reduced ivermectin efficacy was identified in sheep and goats in the four study locations. Using a paired statistic, the efficacy of a therapeutic dose in sheep was 75.6% (90% upper credible limit (UCrL): 77.5%), while twice the recommended dose led to a reduction of 92.6% (90% UCrL: 93.3%). In goats, the FECRs of a therapeutic dose were 72.9 – 95.3% (90% UCrL range: 73.6 – 95.7%) in Bulbul, Nyala Domaia, Nyala University farm and Kass. Twice the dose recommended for goats in Bulbul revealed a 90% UCrL of 87.6%. All post-treatment faecal cultures contained only Haemonchus spp. larvae. The experimental infection trials in sheep and goats supported our findings from field trials and calculated upper 90% CrL of below 98.9%. For the first time highly ivermectin resistant H. contortus populations have been identified in sheep and goats in Sudan, and resistance was experimentally confirmed.

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Section: Discussionmentioning

confidence: 99%

First evaluation and detection of ivermectin resistance in gastrointestinal nematodes of sheep and goats in South Darfur, Sudan

Mohammedsalih,

Ibrahim,

Juma

et al. 2024

Preprint

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“…This leads to major problems in veterinary medicine and affects both agricultural income and animal welfare. Therefore it is very important to either use the anthelmintics in a way that minimizes the development of anthelminthic resistance in the parasitic nematodes or to find novel alternate drugs that will reduce the dependence on these already resistant drugs [ 37 , 38 ]. In the quest for alternative medicines against parasitic nematodes, research efforts were invested in assessing the effectiveness of plant metabolites, including flavonoids [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Targeting the nervous system of the parasitic worm, Haemonchus contortus with quercetin

Goel¹,

Sharma²,

Chakroborty³

et al. 2023

Heliyon

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“…Goat nematodes. Although resistance in goat nematodes has been widely reported overseas, 18 very little testing of anthelmintic resistance in worms isolated from goats in Australia has been reported. However, as goats and sheep are generally infected with the same species of worms, and are often present on the same property in the case of farmed goats (as distinct from rangeland goats), the goat resistance situation in Australia is believed to be similar to that for sheep.…”

Section: Nematode Parasitesmentioning

confidence: 99%

The current status and outlook for insecticide, acaricide and anthelmintic resistances across the Australian ruminant livestock industries: assessing the threat these resistances pose to the livestock sector

Kotze

Hunt

2023

Aust Veterinary J

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The Australian ruminant livestock industries are faced with the need to control parasitic infectious diseases that can seriously impact the health of animals. However, increasing levels of resistance to insecticides, anthelmintics and acaricides are substantially reducing the ability to control some of these parasites. Here we review the current situation with regard to chemical resistances in parasites across the various sectors of the Australian ruminant livestock industries and assess the level of threat that these resistances pose to the sustainability of these sectors in the short to long terms. We also look at the extent to which testing for resistance occurs across the various industry sectors, and hence how well‐informed these sectors are of the extent of chemical resistance. We examine on‐farm management practices, breeding of parasite‐resistant animals, and non‐chemical therapeutics that may act as short to long term means to reduce the current reliance on chemicals for parasite control. Finally, we look at the balance between the prevalence and magnitude of current resistances and the availability and adoption rates of management, breeding and therapeutic alternatives in order to assess the parasite control outlook for the various industry sectors.

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Anthelmintic resistance of gastrointestinal nematodes in goats: A systematic review and meta-analysis

Cited by 12 publications

References 107 publications

First evaluation and detection of ivermectin resistance in gastrointestinal nematodes of sheep and goats in South Darfur, Sudan

First evaluation and detection of ivermectin resistance in gastrointestinal nematodes of sheep and goats in South Darfur, Sudan

Targeting the nervous system of the parasitic worm, Haemonchus contortus with quercetin

The current status and outlook for insecticide, acaricide and anthelmintic resistances across the Australian ruminant livestock industries: assessing the threat these resistances pose to the livestock sector

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