Anthocyanin attenuates high salt-induced hypertension via inhibiting the hyperactivity of the sympathetic nervous system

Xu, Cheng; Zhu, Jin-Xia; Gong, Guanghua; Guo, Li; Zhang, Ye; Zhang, Ziyue; Ma, Chunlan

doi:10.1080/10641963.2023.2233717

Cited by 10 publications

(3 citation statements)

References 42 publications

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“…In a pre-clinical trial by Shaughnessy et al, long-term (2 months) blueberry supplementation significantly reduced systolic blood pressure as early as 4 weeks (19% reduction) with continued decline subsequently [328]. As shown by Xu et al, intracranial infusion of anthocyanin extract decreased the sympathetic nervous system activity and reduced blood pressure in salt-induced hypertensive rats [329]. Furthermore, anthocyanins administered at 50, 100, or 200 mg/kg decreased systolic and diastolic blood pressure as well as heart rate in hypertensive rats in a dose-dependent manner, at least in part through RAAS inhibition [330].…”

Section: • Vascular Function Hypertensionmentioning

confidence: 94%

Resveratrol and beyond: The Effect of Natural Polyphenols on the Cardiovascular System: A Narrative Review

Gál,

Halmosi,

Gallyas

et al. 2023

Biomedicines

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Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality worldwide. Unhealthy dietary habits have clearly been shown to contribute to the development of CVDs. Beyond the primary nutrients, a healthy diet is also rich in plant-derived compounds. Natural polyphenols, found in fruits, vegetables, and red wine, have a clear role in improving cardiovascular health. In this review, we strive to summarize the results of the relevant pre-clinical and clinical trials that focused on some of the most important natural polyphenols, such as resveratrol and relevant flavonoids. In addition, we aim to identify their common sources, biosynthesis, and describe their mechanism of action including their regulatory effect on signal transduction pathways. Finally, we provide scientific evidence regarding the cardiovascular benefits of moderate, long-term red wine consumption.

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Section: • Vascular Function Hypertensionmentioning

confidence: 94%

Resveratrol and beyond: The Effect of Natural Polyphenols on the Cardiovascular System: A Narrative Review

Gál,

Halmosi,

Gallyas

et al. 2023

Biomedicines

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“…There are relatively few published animal studies that have determined the effects of anthocyanins on blood pressure (BP). Xu et al [ 179 ] showed that chronic infusion of anthocyanins into the paraventricular nucleus of rats with salt-induced hypertension reduced BP and peripheral sympathetic nerve activity. Anthocyanins from Hibiscus sabdariffa reduced salt-induced hypertension in rats by inhibiting components of the renin–angiotensin–aldosterone system [ 178 ].…”

Section: The Effects Of Anthocyanins On the Prevention And Supportive...mentioning

confidence: 99%

Effects of Anthocyanins on Components of Metabolic Syndrome—A Review

Godyla-Jabłoński,

Raczkowska,

Jodkowska

et al. 2024

Nutrients

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Metabolic syndrome (MetS) is a significant health problem. The co-occurrence of obesity, carbohydrate metabolism disorders, hypertension and atherogenic dyslipidaemia is estimated to affect 20–30% of adults worldwide. Researchers are seeking solutions to prevent and treat the conditions related to MetS. Preventive medicine, which focuses on modifiable cardiovascular risk factors, including diet, plays a special role. A diet rich in fruits and vegetables has documented health benefits, mainly due to the polyphenolic compounds it contains. Anthocyanins represent a major group of polyphenols; they exhibit anti-atherosclerotic, antihypertensive, antithrombotic, anti-inflammatory and anticancer activities, as well as beneficial effects on endothelial function and oxidative stress. This review presents recent reports on the mechanisms involved in the protective effects of anthocyanins on the body, especially among people with MetS. It includes epidemiological data, in vivo and in vitro preclinical studies and clinical observational studies. Anthocyanins are effective, widely available compounds that can be used in both the prevention and treatment of MetS and its complications. Increased consumption of anthocyanin-rich foods may contribute to the maintenance of normal body weight and modulation of the lipid profile in adults. However, further investigation is needed to confirm the beneficial effects of anthocyanins on serum glucose levels, improvement in insulin sensitivity and reduction in systolic and diastolic blood pressure.

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“…Procyanidins, with their potent antioxidant activity, can scavenge free radicals and oxidative byproducts within the body, safeguarding cells from damage caused by oxidative stress. Moreover, the suppression of immune stress contributes to alleviating inflammatory responses [ 124 ].…”

Section: Mechanisms Of Procyanidins In Repairing Cartilage Injury Aft...mentioning

confidence: 99%

Research progress of procyanidins in repairing cartilage injury after anterior cruciate ligament tear

Chen,

Li,

et al. 2024

Heliyon

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Anthocyanin attenuates high salt-induced hypertension via inhibiting the hyperactivity of the sympathetic nervous system

Cited by 10 publications

References 42 publications

Resveratrol and beyond: The Effect of Natural Polyphenols on the Cardiovascular System: A Narrative Review

Resveratrol and beyond: The Effect of Natural Polyphenols on the Cardiovascular System: A Narrative Review

Effects of Anthocyanins on Components of Metabolic Syndrome—A Review

Research progress of procyanidins in repairing cartilage injury after anterior cruciate ligament tear

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