Anthocyanin-rich cherry juice does not improve acute cognitive performance on RAVLT

Caldwell, Katherine; Charlton, Karen E; Roodenrys, Steven; Jenner, Andrew

doi:10.1179/1476830515y.0000000005

Cited by 22 publications

(26 citation statements)

References 17 publications

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“…These findings are consistent with those of recent human and animal studies showing improvement in cognitive performance in these domains with dietary supplementation with other anthocyanin-rich food sources (11)(12)(13)(31)(32)(33). Although, we have previously shown that intake of cherry juice does not impact acute cognition over 6h (34). The ability of flavonoids to modulate Alzheimer's disease progression is still poorly understood (17).…”

Section: Discussionmentioning

confidence: 99%

Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia

et al. 2015

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Richards, R. (2017). Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia. European Journal of Nutrition, 56 (1), 333-341.Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia AbstractPurpose Dietary flavonoids, including anthocyanins, may positively influence cognition and may be beneficial for the prevention and treatment of dementia. We aimed to assess whether daily consumption of anthocyanin-rich cherry juice changed cognitive function in older adults with dementia. Blood pressure and anti-inflammatory effects were examined as secondary outcomes. Methods A 12-week randomised controlled trial assessed cognitive outcomes in older adults (+70 year) with mild-to-moderate dementia (n = 49) after consumption of 200 ml/day of either a cherry juice or a control juice with negligible anthocyanin content. Blood pressure and inflammatory markers (CRP and IL-6) were measured at 6 and 12 weeks. ANCOVA controlling for baseline and RMANOVA assessed change in cognition and blood pressure. Results Improvements in verbal fluency (p = 0.014), short-term memory (p = 0.014) and long-term memory (p ≤ 0.001) were found in the cherry juice group. A significant reduction in systolic (p = 0.038) blood pressure and a trend for diastolic (p = 0.160) blood pressure reduction was evident in the intervention group. Markers of inflammation (CRP and IL-6) were not altered. Conclusion Inclusion of an anthocyanin-rich beverage may be a practical and feasible way to improve total anthocyanin consumption in older adults with mild-tomoderate dementia, with potential to improve specific cognitive outcomes. Methods: A 12-week randomised controlled trial assessed cognitive outcomes in older adults (+70y) with mild to moderate dementia (n=49) after consumption of 200ml/day of either a cherry juice or a control juice with negligible anthocyanin content. Blood pressure and inflammatory markers (CRP, IL-6) were measured at 6 and 12 weeks. ANCOVA controlling for baseline and RMANOVA assessed change in cognition and blood pressure.Results: Improvements in verbal fluency (P=0.014), short term memory (P=0.014) and long term memory (P=<0.001) were found in the cherry juice group. A significant reduction in systolic (P=0.038) blood pressure and a trend for diastolic (P=0.160) blood pressure reduction was evident in the intervention group. Markers of inflammation were not altered. Conclusion:Inclusion of an anthocyanin-rich beverage may be a practical and feasible way to improve total anthocyanin consumption in older adults with mild to moderate dementia, with potential to improve specific cognitive outcomes.3

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Section: Discussionmentioning

confidence: 99%

Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia

et al. 2015

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“…Five short cognitive interviewer-administered tests [38,39] were administered by trained investigators at baseline and 6h on both testing occasions to determine any acute changes in cognition.…”

Section: Cognitive Tasksmentioning

confidence: 99%

“…Despite evidence from epidemiological and intervention studies indicating that anthocyanin intake is linked with improved cognition [15,17] and a slower cognitive decline [18], the mechanisms by which anthocyanins may exert acute effects on brain function remains unclear and evidence is inconsistent. A crossover study [19] found that high anthocyanin cherry juice consumption did not result in any significant acute effects on a battery of cognitive tests in either younger or older adults. Contrary to this, Watson et.al, (2015) [20] observed a cognitive benefit of acute blackcurrant supplementation in healthy younger adults possibly explained by an association between monoamine oxidase (MAO) inhibition and improved attention.…”

Section: Introductionmentioning

confidence: 99%

Anthocyanin-rich plum juice reduces ambulatory blood pressure but not acute cognitive function in younger and older adults: a pilot crossover dose-timing study

et al. 2017

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“…The acute cross‐over trial by Caldwell et al . found no significant change in cognition 6 h post‐intervention but the small numbers of participants suggest that it was likely to be underpowered to observe cognitive effects.…”

Section: Discussionmentioning

confidence: 99%

“…Statistical pooling of the data from the seven studies considered eligible for the review (39)(40)(41)(42)(43)(44)(45) was not possible because of the large clinical and methodological diversity of the studies. This heterogeneity resulted from variability in the characteristics of the participants and type of intervention (including food sources and dose of anthocyanins), varying study designs and study duration, as well as differences in choice of cognitive outcomes.…”

Section: Description Of Studiesmentioning

confidence: 99%

Food‐based anthocyanin intake and cognitive outcomes in human intervention trials: a systematic review

Kent

Charlton

Netzel

et al. 2016

J Human Nutrition Diet

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Anthocyanin-rich cherry juice does not improve acute cognitive performance on RAVLT

Cited by 22 publications

References 17 publications

Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia

Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia

Anthocyanin-rich plum juice reduces ambulatory blood pressure but not acute cognitive function in younger and older adults: a pilot crossover dose-timing study

Food‐based anthocyanin intake and cognitive outcomes in human intervention trials: a systematic review

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