Anthocyanins from muscadine (Vitis rotundifolia) grape fruit

Metabolic engineering of anthocyanin pathway inArtemisia annuacells does not exclude the expression of artemisinin pathway

“…Anthocyanins are strong antioxidative pigments (Kano et al 2005; Mohammad et al 2021; Bishayee et al 2010). Especially, the biosynthesis of anthocyanins is highly induced by stress conditions, such as UV-radiation (Hatier and Gould 2008; Merzlyak et al 2008; Rowan et al 2009; Shi and Xie 2014; Yuzuak and Xie 2022) and anthocyanins have strong scavenging capacity to remove ROS (Fan et al 2023; Pang et al 2023; Qu et al 2018; Zhang et al 2016). Based on previous reports, our hypothesis is if an antioxidative condition can inhibit the biosynthesis of artemisinin, the engineering of anthocyanins likely excludes the formation of artemisinin in non-GT cells.…”

“…Anthocyanins are a group of pink/red/purple/blue flavonoid pigments with strong antioxidative activities that protect plants from stress-induced damages (Kano et al 2005; Yuzuak and Xie 2022; Shi and Xie 2014). To date, the biosynthesis of anthocyanins has gained intensive studies in biochemistry, genetics, metabolic engineering, and applications (Shi and Xie 2014; Holton and Cornish 1995; Li et al 2022; Zhang et al 2014).…”

Unveiling the potential of Muscadine grape Skin extract as an innovative therapeutic intervention in cancer treatment

“…It is worth noting that the phytochemical composition of Muscadine grapes sets them apart from other grape types due to their elevated levels of resveratrol, anthocyanin, ellagic acid, and ellagic acid precursors ( Narduzzi et al, 2015 ). Anthocyanins primarily contribute to these grapes’ red and purple coloration ( Yuzuak & Xie, 2022 ). These phytochemicals exhibit potent antioxidant properties (Mendonca et al, 2019) and demonstrate anti-cancer effects through various mechanisms, including hindering the formation of DNA adducts induced by carcinogens ( W. Li et al, 2022 ), impeding DNA synthesis in breast cancer cells ( Collard et al, 2020 ), and retarding angiogenesis in specific tumor types ( Burton et al, 2015 ; God et al, 2007 ; W. Li et al, 2022 ).…”

“…Furthermore, ongoing research is being done to investigate the safety profile and toxicological features of MGSE, which has shown encouraging results. Although Curcumin is known to have difficulties with bioavailability, ongoing research is focused on developing methods to improve the absorption of MGSE, which may help overcome this restriction ( Stewart et al, 2023 ; Yuzuak & Xie, 2022 ).…”

HPLC-MS(n) Applications in the Analysis of Anthocyanins in Fruits

“…Fruits are one of the main sources of novel anthocyanins with valuable health benefits [8,26,27]. A large number of anthocyanins have been isolated from fruits (Table 2).…”