2021
DOI: 10.1039/d0fo02936j
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Anthocyanins from the fruits ofLycium ruthenicumMurray improve high-fat diet-induced insulin resistance by ameliorating inflammation and oxidative stress in mice

Abstract: Anthocyanins from the fruits of Lycium ruthenicum Murray improve high-fat diet-induced insulin resistance by ameliorating inflammation and oxidative stress in mice.

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Cited by 61 publications
(43 citation statements)
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“…One recent study confirmed that ACN supplementation lowered body weight and improved the TG and LDL-C levels in the serum of HFD-induced obesity rats [ 40 ]. Similar results were reported in mice fed a HFD [ 41 ]. However, these two studies focused on the antiobesity effects of anthocyanins mixtures.…”
Section: Discussionsupporting
confidence: 89%
“…One recent study confirmed that ACN supplementation lowered body weight and improved the TG and LDL-C levels in the serum of HFD-induced obesity rats [ 40 ]. Similar results were reported in mice fed a HFD [ 41 ]. However, these two studies focused on the antiobesity effects of anthocyanins mixtures.…”
Section: Discussionsupporting
confidence: 89%
“…3- O -[6- O -(4- O -(trans-p-coumaroyl)-a- l -rhamnopyranosyl)-b- d -glucopyranoside]-5- O - [b- d -glucopyranoside] ( Figure S1 ) is considered to be the main component of anthocyanin from the fruits of L. ruthenicum [ 13 , 14 ]. It has been reported that anthocyanins from the fruits of L. ruthenicum (ACN) possess a wide range of biological functions, including antioxidant and anti-inflammatory properties and can change the gut microbiota and reduce the risk of chronic diseases, such as obesity [ 15 , 16 , 17 ]. However, the role of ACN in the prevention of obesity is still not fully understood.…”
Section: Introductionmentioning
confidence: 99%
“…On the one hand, HFDmediated oxidative stress and ER stress trigger the inflammatory cascade JNK pathway and further lead to IRS-1 phosphorylation at the serine site (Ser307) instead of tyrosine sites, subsequently blocking the insulin pathway. 20 Furthermore, the HFDactivated NF-κB pathway results in higher levels of proinflammatory cytokines including TNF-α, IL-6, and leptin, which also dephosphorylates Akt and suppresses the insulin signaling pathway. 24 Similarly, a previous study also revealed that glucose uptake was notably increased in TNF-α-deficient mice.…”
Section: ■ Discussionmentioning
confidence: 99%
“…In addition to lipid metabolism disorder, HFD also contributes to dysregulation of glucose metabolism. , Diet-induced dysregulation of glucose metabolism usually results in glucose accumulation in blood and is accompanied with insulin resistance, reduction in glucose uptake, glycolysis and glycogen, and enhancement of gluconeogenesis in the liver, adipose tissue, and muscle . It is well known that glucose is transported into the target organs by glucose transporters (e.g., GLUT2 and GLUT4) and insulin activates glucokinase translocation to the cytoplasm to phosphorylate glucose and initiates glycolysis .…”
Section: Discussionmentioning
confidence: 99%