Anthocyanins: New techniques and challenges in microencapsulation

Tarone, Adriana Gadioli; Cazarin, Cínthia Baú Betim; Maróstica, Mário Roberto

doi:10.1016/j.foodres.2020.109092

Cited by 177 publications

(119 citation statements)

References 118 publications

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“…The rapid progress of nanotechnology has brought feasible way for the application of ACNs. It has been shown that the use of protein‐based nanocarriers not only can improve the stability and solubility of the bioactive substances, but also can effectively sustain and/or control their release and delivery throughout the body (Liang et al., 2017; Tarone et al., 2020). Moreover, protein‐based nanocarriers are generally regarded as safe because of their excellent biocompatibility and biodegradability and can be directly ingested as nutrients.…”

Section: Introductionmentioning

confidence: 99%

A molecular docking and molecular dynamics simulation study on the interaction between cyanidin ‐ 3 ‐O ‐glucoside and major proteins in cow's milk

Pan

Zhao

et al. 2020

J. Food Biochem.

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The objective of this study was to investigate the molecular interaction and complex stability of four major cow's milk (CM) proteins (α-LA, β-LG, α s1-CA, and β-CA) with cyanidin-3-O-glucoside (C3G) using computational methods. The results of molecular docking analysis revealed that hydrogen bond and hydrophobic interaction were the main binding forces to maintain the stability of the C3G-CM protein complexes. Molecular dynamics simulation results showed that all complexes except for C3Gα s1-CA were found to reach equilibrium within 50 ns of simulation. α s1-CA and β-CA switched to a more compact conformation after binding with C3G. Additionally, the radius of gyration, number of hydrogen bond, radial distribution function, and interaction energy showed that β-CA is the best C3G carrier protein among the four CM proteins. This study can provide valuable information for CM proteins to serve as C3G delivery carriers. Practical applications Anthocyanins (ACNs) are flavonoid-based pigments that play an important functional role in regulating human's health. Cow's milk (CM) proteins are the most representative protein-based carriers that can improve the short-term bioavailability and stability of ACNs. Thus, it is important to study the interactions between ACNs and CM proteins at the molecular level for the development of effective ACNs delivery carriers. Our study showed that caseins (α s1-CA and β-CA) had more hydrophobic and hydrogen-bonding sites with cyanidin-3-O-glucoside (C3G) than whey proteins using computational methods. Among the four CM proteins, β-CA was the best C3G carrier protein showing the best interaction stability with C3G. Thus, it is helpful for us to screen effective ACNs carriers from multiple protein sources by computational methods.

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Section: Introductionmentioning

confidence: 99%

A molecular docking and molecular dynamics simulation study on the interaction between cyanidin ‐ 3 ‐O ‐glucoside and major proteins in cow's milk

Pan

Zhao

et al. 2020

J. Food Biochem.

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“…The taste, smell and color of ACNs became more acceptable to consumers with encapsulation of isotonic drinks and extracts of fruits. Besides, the beverages enriched with inulin microcapsules had also better stability during storage (Tarone et al, 2020).…”

Section: Discussion Therapeutic Limitations and Clinical Pitfallsmentioning

confidence: 99%

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

et al. 2020

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Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.

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“…Many morphologies can be produced for encapsulation, but three main morphologies are more commonly used: mononuclear capsules, which have one core enveloped by a wall material, a polynuclear core, which has two or more nuclei covered by a wall material; and aggregates, which have many nuclei embedded in the matrix. 3 Several parameters are used to verify the quality of encapsulation, and their characteristics depend on the encapsulation process used. Encapsulation efficiency is one of the most important quality parameters of the encapsulation technique because it determines the ability of the wall material to hold the core material inside the microcapsules.…”

Section: Current Research On Microencapsulation Of Extractsmentioning

confidence: 99%

“…The ζ-Potential measurement can be used to verify the stability of aggregation and to control the retention and release of bioactive molecules among other functions. 3 In many reviews, microencapsulation has been used for protection, modification, and controlled delivery of many food ingredients, including acidulants, flavors, sweeteners, colorants, enzymes and microorganisms, antioxidants, leavening agents, and nutritional ingredients such as vitamins and minerals. 6 Research on microencapsulation of extract which had been reported in many publications was summarized in Table 1.…”

Section: Current Research On Microencapsulation Of Extractsmentioning

confidence: 99%

“…Microencapsulation is a promising possibility to stabilize extracts and allow their addition to products in a more stable form. [2][3][4] The antioxidant characteristics enable their use in food, cosmetics and pharmaceuticals, either to increase the shelf life of these products, reducing the amount of synthetic antioxidants in their composition, or to promote beneficial effects to the human body. However, as antioxidants compounds are unstable, the application of these bioactive compounds to new products is very restricted.…”

Section: Introductionmentioning

confidence: 99%

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Microparticles of Herbal Extracts with Antioxidant Activity

Zulham¹,

Wilar²,

Susilawati³

et al. 2021

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A number of coating or matrix materials can be selected depending upon desired properties of the final microcapsule including stability and unaltered bioavailability, as well as compatibility with selected microencapsulation techniques and high encapsulation efficiency. Among them, proteins, sugars, starches, gums, lipids, and cellulose derivatives are most popular, as covered elsewhere ABSTRACT Plants that have antioxidant content have been shown to have efficacy on the body, antioxidants have several drawbacks including being sensitive to environmental factors such as light, heat, pH, and oxygen. Microencapsulation is a method that has several advantages including providing several benefits, namely microparticles formulated to protect the core from the environment, cover up discomfort, maintain volatility or cell survival, separate incompatible substances, protect the body from side effects, and optimize, extend, or target drug effects. The choice of the type of polymer used will determine the characteristics of the microparticles produced, therefore a suitable coating material is needed to produce the microparticles. This review article was made to find out the results of research conducted in the manufacture of microparticles by using polymers which are expected to be useful to provide information on the basis of the selection of polymers and methods of making microparticles produced to maintain the stability of substances that are efficacious as antioxidants. Based on the results of the literature search, microencapsulation is a method used to maintain the stability of antioxidant content that has a therapeutic effect.

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Anthocyanins: New techniques and challenges in microencapsulation

Cited by 177 publications

References 118 publications

A molecular docking and molecular dynamics simulation study on the interaction between cyanidin ‐ 3 ‐O ‐glucoside and major proteins in cow's milk

A molecular docking and molecular dynamics simulation study on the interaction between cyanidin ‐ 3 ‐O ‐glucoside and major proteins in cow's milk

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

Microparticles of Herbal Extracts with Antioxidant Activity

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