Anthocyanosides of Vaccinium myrtillus (Bilberry) for Night Vision—A Systematic Review of Placebo-Controlled Trials

Canter, PH; Ernst, Edzard

doi:10.1016/j.survophthal.2003.10.006

Cited by 121 publications

(93 citation statements)

References 9 publications

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“…Among them, blueberries became well known and often consumed due to their uses for treating biliary disorders, coughs, tuberculosis, diabetes (Martineau et al, 2006;Valentová et al, 2007) and visual disorders (Canter and Ernst, 2004). Blueberries contain high level of anthocyanin and phenolic compounds with high in vitro antioxidant capacities compared with other fruits (Wang and Jiao, 2000).…”

Section: Introductionmentioning

confidence: 99%

Comparative Polyphenolic Content and Antioxidant Activities of Some Wild and Cultivated Blueberries from Romania

Bunea

Rugină

Pintea

et al. 2011

Not Bot Hort Agrobot Cluj

130

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Two wild and three cultivated blueberry varieties ('Elliot' , 'Bluecrop' and 'Duke') from Romania were analyzed comparatively in order to determine the total polyphenols, total anthocyanins, total flavonoids content and measuring the antioxidant activity using three different single electron transfer-based assays, Trolox equivalent antioxidant capacity (ABTS), ferric reducing ability (FRAP), 2,2-diphenylpicrylhydrazil radical scavenging capacity (DPPH) and one hydrogen atom transfer-assay, oxygen radical absorbance capacity (ORAC). Total polyphenols content ranged from 424.84 -819.12 mg GAE/100 g FW, total flavonoids ranged from 84.33-112.5 mg QE /100 g FW and total anthocyanins ranged from 100.58-300.02 C3GE/100g FW. The anthocyanins were separated and quantified using RP-HPLC-DAD. In Vaccinium myrtillus, petunidin-3-glucoside and delphinidin-3-glucoside have the highest contribution to the anthocyanin content while in Vaccinium corymbosum, peonidin-3-galactoside represent the major anthocyanin. Except for ORAC assay (r=0.765), all antioxidant activity values obtained were highly correlated with total polyphenol content (0.923≤ r ≤0.986). Wild blueberries had higher total polyphenols content and also antioxidant activity compared with cultivated ones.

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Section: Introductionmentioning

confidence: 99%

Comparative Polyphenolic Content and Antioxidant Activities of Some Wild and Cultivated Blueberries from Romania

Bunea

Rugină

Pintea

et al. 2011

Not Bot Hort Agrobot Cluj

130

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“…The anthocyanin-rich VME (containing ~39% anthocyanins) used in the current study was provided in powder form by Wakasa Seikatsu Co., Ltd. (Kyoto, Japan). VME contains a total of 15 anthocyanins in all possible combinations of 5 anthocyanidins (cyanidin, delphinidin, peonidin, petunidin and malvidin) containing 3 types of sugar moieties (3-O-arabinosides, 3-O-glucosides and 3-O-galactosides) (35). The powder was stored at -20˚C until use and dissolved in distilled water (DW) to a concentration of 50 mg/ml (5%) prior to administration.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, in the present study, the effects of an anthocyanin-rich bilberry (Vaccinium myrtillus) extract (VME) on bone metabolism were investigated in ovariectomized (Ovx) rats. Bilberry, a member of the Ericaceous family, is a low-growing shrub native to Europe and North America and is related to, while distinct from, varieties of the North American blueberry (V. corymbosum) (35). The anthocyanin-rich VME has been utilized in the treatment of various eye conditions, including cataracts and glaucoma, as well as for enhancing night vision, due to its proposed anti-inflammatory and antioxidant effects (35,36).…”

Section: Introductionmentioning

confidence: 99%

“…Bilberry, a member of the Ericaceous family, is a low-growing shrub native to Europe and North America and is related to, while distinct from, varieties of the North American blueberry (V. corymbosum) (35). The anthocyanin-rich VME has been utilized in the treatment of various eye conditions, including cataracts and glaucoma, as well as for enhancing night vision, due to its proposed anti-inflammatory and antioxidant effects (35,36). The Ovx rat model is the current FDA-approved model for the investigation of menopausal bone changes (37).…”

Section: Introductionmentioning

confidence: 99%

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Effect of anthocyanin-rich bilberry extract on bone metabolism in ovariectomized rats

et al. 2017

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Abstract. Menopause is associated with increased oxidative stress, which serves a role, in part, in the pathogenesis of postmenopausal bone loss. Fruits and vegetables are rich in antioxidative nutrients and phytochemicals. Berries are a natural source of anthocyanins, and their intake may improve bone health. The aim of the present study was to determine the effect of an anthocyanin-rich bilberry extract (VME) on bone metabolism in an ovariectomized (Ovx) rat. Female Sprague-Dawley rats (12 weeks old) were randomly divided into the following four groups: Baseline, Sham, Ovx and Ovx+VME (n=8-12 rats per group). Rats in the Baseline group were sacrificed immediately, while those in the other groups were subjected to either sham operation (Sham) or bilateral Ovx (Ovx and Ovx+VME). Rats in the Ovx+VME group were administered VME daily at a dose of 500 mg/kg body weight. At 8 weeks after surgery, bone mass and bone histomorphometry were evaluated. The femur bone mineral density (BMD) in the Ovx group was significantly lower than that in the Sham group (P<0.01). Supplementation of VME in the Ovx rats did not result in an increase in BMD. Histomorphometric analyses revealed that Ovx resulted in decreased measures of bone volume and trabecular number and increased measures of osteoid volume, mineralizing surface and bone formation rates (all P<0.01), whereas VME had no significant effects on these parameters. The present findings indicate that VME did not alter bone metabolism in Ovx rats, suggesting that consumption of VME may not be helpful in preventing postmenopausal bone loss.

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“…Rice bran (RB) phytochemicals (flavonoids, phenolics, tannins, sterols, tocols, γ-oryzanols, and amino acids) are known for several pharmacological properties such as antioxidant [2], anti-colitis [3], anticancer, antitumor, antimutagenic [4], antidiabetes [5], ocular impairment [6], anti-aging [7], and anti-inflammatory [8].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Stability of Thai Purple Rice Bran-Based Cosmetic Products

Chaiyasut

Kesika

Sakdakampanat

et al. 2018

Asian J Pharm Clin Res

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Objective: The rice bran (RB) phytochemicals are known for several pharmacological properties. The current study was aimed to extract the active principles from Thai purple RB, formulate the cosmetic products, and evaluate the physical property and stability of the products.Methods: Purple RB was extracted using 80% ethanol, and total phenolic and anthocyanin contents were measured using high-pressure liquid chromatography (HPLC) and spectrophotometric methods. Rice bran oil (RBO) was obtained by cold press method, and oryzanol content was determined using HPLC. The antioxidant capacity of RBO and purple rice bran extract (PRE) was assessed using spectrophotometric methods. The cosmetic products were formulated with PRE and fermented and distilled purple rice solution (FDPRS). RBO was also used as an ingredient in the formulation of solid soap. The stability of the formulations was also assessed. The heavy metal and microbial contamination were determined using atomic absorption spectrometry and plating assay, respectively. Results:The yield of PRE and RBO was 0.92 and 1.62%, respectively. The total phenolic and anthocyanin content of PRE was 305.30±6.15 mg gallic acid/g of extract and 877.33±87.73 mg cyanidin chloride/g of extract, respectively. Oryzanol content of RBO was 6.33±0.09 mg/g of RBO. RBO, PRE, and FDPRS exhibited high antioxidant capacity. The cosmetic formulations were observed to be physically stable in the heat-cool cycle, and the stability of the active compounds was not affected while stored at 30°C for 2 months. The storage temperature affected the phenolic compounds present in the cosmetic formulations, especially at 45°C. There was no significant decrease in oryzanol content of soap formulation. All the formulations were free from microbial and heavy metal contamination. Conclusion:The RB phytochemical-based cosmetic products are rich in antioxidants, stable, and free from heavy metals and microbial contamination, and further fine-tuning of the formulation may achieve the market quality.

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Anthocyanosides of Vaccinium myrtillus (Bilberry) for Night Vision—A Systematic Review of Placebo-Controlled Trials

Cited by 121 publications

References 9 publications

Comparative Polyphenolic Content and Antioxidant Activities of Some Wild and Cultivated Blueberries from Romania

Comparative Polyphenolic Content and Antioxidant Activities of Some Wild and Cultivated Blueberries from Romania

Effect of anthocyanin-rich bilberry extract on bone metabolism in ovariectomized rats

Formulation and Evaluation of Stability of Thai Purple Rice Bran-Based Cosmetic Products

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