Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles

Shi, Yang; Cardoso, Renata Martins; Nostrum, Cornelus F. van; Hennink, Wim E.

doi:10.1039/c4py01759e

Cited by 27 publications

(22 citation statements)

References 33 publications

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“…Temperature is one of the most convenient and effective factors to control the drug release compared with other stimuli 40 - 42 . Normally, pathophysiological conditions, such as inflammation and tumors, have higher temperatures than normal tissues 43 .…”

Section: Design Rationale Of Smart Drug Delivery Nanoplatformsmentioning

confidence: 99%

The Smart Drug Delivery System and Its Clinical Potential

Liu¹,

Yang²,

Xiong³

et al. 2016

Theranostics

828

413

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With the unprecedented progresses of biomedical nanotechnology during the past few decades, conventional drug delivery systems (DDSs) have been involved into smart DDSs with stimuli-responsive characteristics. Benefiting from the response to specific internal or external triggers, those well-defined nanoplatforms can increase the drug targeting efficacy, in the meantime, reduce side effects/toxicities of payloads, which are key factors for improving patient compliance. In academic field, variety of smart DDSs have been abundantly demonstrated for various intriguing systems, such as stimuli-responsive polymeric nanoparticles, liposomes, metals/metal oxides, and exosomes. However, these nanoplatforms are lack of standardized manufacturing method, toxicity assessment experience, and clear relevance between the pre-clinical and clinical studies, resulting in the huge difficulties to obtain regulatory and ethics approval. Therefore, such relatively complex stimulus-sensitive nano-DDSs are not currently approved for clinical use. In this review, we highlight the recent advances of smart nanoplatforms for targeting drug delivery. Furthermore, the clinical translation obstacles faced by these smart nanoplatforms have been reviewed and discussed. We also present the future directions and perspectives of stimuli-sensitive DDS in clinical applications.

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Section: Design Rationale Of Smart Drug Delivery Nanoplatformsmentioning

confidence: 99%

The Smart Drug Delivery System and Its Clinical Potential

Liu¹,

Yang²,

Xiong³

et al. 2016

Theranostics

828

413

View full text Add to dashboard Cite

show abstract

“…Because P(HPMA) itself is highly water-soluble, it can only be used as the core in polymeric micelles when it is chemically modified with hydrophobic moieties. For example, micelle-forming PEG-P(HPMA) block copolymers have been described in which the P(HPMA) block was functionalized with oligolactate [13], benzoyl [14], anthracene [15], ethylcarbonate [16] and lipoic acid groups [17]. PEG-P(HPMAbenzoyl) micelles developed in the group of Hennink showed excellent stability as well as a high paclitaxel loading due to polymer-polymer and polymer-drug p-p stacking effects [14].…”

Section: Introductionmentioning

confidence: 99%

Reversibly core-crosslinked PEG-P(HPMA) micelles: Platinum coordination chemistry for competitive-ligand-regulated drug delivery

Buwalda

Nottelet

Béthry

et al. 2019

Journal of Colloid and Interface Science

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“…[48] Due to hydrolysis of the polyester backbone, the obtained CCPM are biodegradable. Besides CuAAC, several other click reactions including [4+4] cycloaddition of anthracene[49], thiol-ene[50] and isocyanates-amine reaction[51] have also been utilized to prepare CCPM. Recently, copper-free click chemistry has been developed as a bioorthogonal tool to avoid the use of toxic copper catalysts,[52] providing an attractive option for chemical crosslinking of PM.…”

Section: Physico-chemical Strategies To Enhance the Stability Of Pmmentioning

confidence: 99%

Physico‐Chemical Strategies to Enhance Stability and Drug Retention of Polymeric Micelles for Tumor‐Targeted Drug Delivery

Shi

Lammers

Storm

et al. 2016

Macromolecular Bioscience

Self Cite

141

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Polymeric micelles (PM) have been extensively used for tumor-targeted delivery of hydrophobic anti-cancer drugs. The lipophilic core of PM is naturally suitable for loading hydrophobic drugs and the hydrophilic shell endows them with colloidal stability and stealth properties. Decades of research on PM have resulted in tremendous numbers of PM-forming amphiphilic polymers, and approximately a dozen micellar nanomedicines have entered the clinic. The first generation of PM can be considered solubilizers of hydrophobic drugs, with short circulation times resulting from poor micelle stability and unstable drug entrapment. To more optimally exploit the potential of PM for targeted drug delivery, several physical (e.g., π-π stacking, stereocomplexation, hydrogen bonding, host-guest complexation, and coordination interaction) and chemical (e.g., free radical polymerization, click chemistry, disulfide and hydrazone bonding) strategies have been developed to improve micelle stability and drug retention. In this review, the most promising physico-chemical approaches to enhance micelle stability and drug retention are described, and how these strategies have resulted in systems with promising therapeutic efficacy in animal models, paving the way for clinical translation, is summarized.

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Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles

Abstract: An anthracene-functionalized thermosensitive block copolymer was synthesized, which formed micelles by heating its aqueous solution above the lower critical solution temperature (LCST). The micelles were subsequently crosslinked by UV illumination at 365 nm with a normal handheld UV lamp.

Cited by 27 publications

References 33 publications

The Smart Drug Delivery System and Its Clinical Potential

The Smart Drug Delivery System and Its Clinical Potential

Reversibly core-crosslinked PEG-P(HPMA) micelles: Platinum coordination chemistry for competitive-ligand-regulated drug delivery

Physico‐Chemical Strategies to Enhance Stability and Drug Retention of Polymeric Micelles for Tumor‐Targeted Drug Delivery

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