Anthraquinone, a New Chemical Oxidation Product of Amitriptyline

Bouche, Raymond

doi:10.1002/jps.2600610646

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1972

1988

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Cited by 8 publications

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“…LITERATURE CITED ng/ml (-), and of amitriptyline oxidation product corresponding to a sample of equivalent concentration In heptane (---) tivity and specificity, or have required extensive purification procedures. Wallace and Dahl (6) described a spectrophotometric determination of amitriptyline based upon oxidation of the drug by alkaline permanganate to anthraquinone (7), a product from the drug possessing a unique ultraviolet absorption spectrum and a high extinction coefficient. Although minor modifications of that procedure have been published (8), it is considered by several investigators (9)(10)(11) to be the method of choice for the analysis of amitriptyline in urine.…”

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confidence: 99%