Spectrophotometric and gas-liquid chromatographic determination of amitriptyline

Abstract

these base stocks. Using the paraffinic blend no-lead calibration for the olefinic, aromatic, and the high-and lowvapor-pressure gasolines resulted in mean errors of 0.0001, 0.0020, 0.0010, and 0.0009 g/USG, respectively. Application of the background correction resulted in corresponding mean errors

Analysis of Conjugated Estrogens in a Vaginal Cream Formulation by Capillary Gas Chromatography

“…The stability of benzoyl peroxide in pharmaceutical gels was reported'by Bollinger et al (2). These authors recommended the use of sodium hydroxide over triethanolamine as a neutralizing agent.…”

Determination of amitriptyline at nanogram levels in serum by electron capture gas-liquid chromatography

“…Previous reports have established that a common oxidation product of amitriptyline and nortriptyline is anthraquinone, a polyaromatic carbonyl compound, (9,10,18) and that ceric sulfate-sulfuric acid serves as a model oxidation system for its production (10). The oxidation of amitriptyline and subsequent detection of anthraquinone by electron capture provides the analyst with a reliable and sensitive gas chromatographic method capable of determining amitriptyline/nortriptyline at low nanogram levels in biologic fluids (Figure 1).…”

“…Earlier spectrophotometric methods (7-9) for the determination of the tricyclic antidepressants lacked a certain level of sensitivity for application to the determination of the drugs in serum or plasma. The authors of this report (10) recently described a spectrophotometric procedure for the determination of amitriptyline and nortriptyline that 1 Department of Pathology. 2 Department of Pharmacology. provided sufficient sensitivity for the measurement of blood levels if both amitriptyline and nortriptyline were analyzed simultaneously at high therapeutic and toxic levels.…”

Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms

“…Various analytical methods have been reported for determination of amitriptyline including spectrofluorimetric [9], spectrophotometric [10][11][12][13][14][15], flow injection method [16], UV-Visible spectrophotometric methods [17,18] based on chromogenic reaction with citric acid-acetic anhydride [19], bromothymol blue [20], ammonium reineckate [21,22], bismuth-hexaiodide [23], and cerium (IV) [24]. Most of these methods however suffer from several interferences by many basic compounds, until several manipulation steps, and can be applied only to relatively high concentration of drugs.…”