Anthraquinone encapsulation into polymeric nanocapsules as a new drug from biotechnological origin designed for photodynamic therapy

Amantino, Camila Fernanda; Neto, Álvaro de Baptista; Badino, Alberto Colli; Siqueira-Moura, Marigilson P.; Tedesco, Antônio Cláudio; Primo, Fernando Lucas

doi:10.1016/j.pdpdt.2020.101815

Cited by 18 publications

(7 citation statements)

References 30 publications

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“…In the case of nanocapsules, Amantino et al developed a nanocapsule containing a poly(lactide-co-glycolide) (PLGA) coating for the encapsulation of an anthraquinone derivative. This nanoparticle increased the drug’s uptake and efficacy, suggesting its promising use in PDT [ 72 ].…”

Section: Nanotechnology Combined With Pdt In Psoriasis Treatment—futu...mentioning

confidence: 99%

An Update on Photodynamic Therapy of Psoriasis—Current Strategies and Nanotechnology as a Future Perspective

Makuch

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Makarec

et al. 2022

IJMS

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Psoriasis (PS) is an immune-mediated skin disease with substantial negative effects on patient quality of life. Despite significant progress in the development of novel treatment options over the past few decades, a high percentage of patients with psoriasis remain undertreated and require new medications with superior long-term efficacy and safety. One of the most promising treatment options against psoriatic lesions is a form of phototherapy known as photodynamic therapy (PDT), which involves either the systemic or local application of a cell-targeting photosensitizing compound, followed by selective illumination of the lesion with visible light. However, the effectiveness of clinically incorporated photosensitizers in psoriasis treatment is limited, and adverse effects such as pain or burning sensations are frequently reported. In this study, we performed a literature review and attempted to provide a pooled estimate of the efficacy and short-term safety of targeted PDT in the treatment of psoriasis. Despite some encouraging results, PDT remains clinically underutilized. This highlights the need for further studies that will aim to evaluate the efficacy of a wider spectrum of photosensitizers and the potential of nanotechnology in psoriasis treatment.

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Section: Nanotechnology Combined With Pdt In Psoriasis Treatment—futu...mentioning

confidence: 99%

An Update on Photodynamic Therapy of Psoriasis—Current Strategies and Nanotechnology as a Future Perspective

Makuch

Dróżdż

Makarec

et al. 2022

IJMS

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“…The microbial production of curcumin by recombinant Escherichia coli cells was revealed by Kim et al [ 46 ], who achieved yields of curcuminoids up to ~100 mg.L −1 . The production of red pigments (anthraquinones) from biotechnological origin was obtained using a mixture of filamentous fungi ( Talaromyces minioluteus and Penicillium minioluteum ) [ 47 ]. Galanie and Smolke [ 48 ] evaluated protoberberine alkaloid production using recombinant yeast ( Saccharomyces cerevisiae ).…”

Section: Compounds From Microbial Origin—biotechnological Photosensit...mentioning

confidence: 99%

Development of Biotechnological Photosensitizers for Photodynamic Therapy: Cancer Research and Treatment—From Benchtop to Clinical Practice

et al. 2022

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Photodynamic therapy (PDT) is a noninvasive therapeutic approach that has been applied in studies for the treatment of various diseases. In this context, PDT has been suggested as a new therapy or adjuvant therapy to traditional cancer therapy. The mode of action of PDT consists of the generation of singlet oxygen (¹O2) and reactive oxygen species (ROS) through the administration of a compound called photosensitizer (PS), a light source, and molecular oxygen (3O2). This combination generates controlled photochemical reactions (photodynamic mechanisms) that produce ROS, such as singlet oxygen (¹O2), which can induce apoptosis and/or cell death induced by necrosis, degeneration of the tumor vasculature, stimulation of the antitumor immune response, and induction of inflammatory reactions in the illuminated region. However, the traditional compounds used in PDT limit its application. In this context, compounds of biotechnological origin with photosensitizing activity in association with nanotechnology are being used in PDT, aiming at its application in several types of cancer but with less toxicity toward neighboring tissues and better absorption of light for more aggressive types of cancer. In this review, we present studies involving innovatively developed PS that aimed to improve the efficiency of PDT in cancer treatment. Specifically, we focused on the clinical translation and application of PS of natural origin on cancer.

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“…Additionally, there is research into novel approaches of functionalization of anthraquinones, and integrating copolymeric nanostructures designed for photodynamic treatments (Amantino et al, 2020). Various AQs have been patented for use in building materials to deter destruction by pests, birds and fungi, highlighting their commercial value (Ballinger, 2015).…”

Section: Introductionmentioning

confidence: 99%

A structure-activity relationship analysis of anthraquinones with antifouling activity against marine biofilm-forming bacteria

et al. 2022

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Anthraquinones (AQs) are chemical scaffolds that have been used both naturally and synthetically for centuries in the food, pharmaceutical, cosmetic and paint industries. AQs, such as citreorosein and emodin, are common additives in antifouling paints which help prevent the global issue of biofouling. To determine the antifouling potential of a family of structurally related compounds nineteen AQs (1–19), were tested for their microbial growth and biofilm adhesion inhibition activity against three marine biofilm forming bacteria, Vibrio carchariae, Pseudoalteromonas elyakovii and Shewanella putrefaciens. More than three-quarters of the tested AQ compounds exhibited activity against both V. carchariae and P. elyakovii at 10 μg/ml whilst exhibiting low antimicrobial effects. The most active compounds (1, 5, 6, 7, 9, 10, 14, 15, 18, 19) were tested for their minimum inhibitory concentrations (MICs) which highlighted that all the tested compounds were highly effective at inhibiting the biofilm growth of P. elyakovii at a very low concentration of 0.001 μg/ml. The variability in MIC for inhibiting the biofilm growth of V. carchariae was assessed by analysing the structure-activity relationships (SARs) between the AQ compounds, and the key structural features leading to improved biofilm growth inhibition activity are reported. Molecular docking analysis was also performed to assess whether interruption of quorum sensing in V. carchariae could be a possible mode of action for the antifouling activity observed.

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Anthraquinone encapsulation into polymeric nanocapsules as a new drug from biotechnological origin designed for photodynamic therapy

Cited by 18 publications

References 30 publications

An Update on Photodynamic Therapy of Psoriasis—Current Strategies and Nanotechnology as a Future Perspective

An Update on Photodynamic Therapy of Psoriasis—Current Strategies and Nanotechnology as a Future Perspective

Development of Biotechnological Photosensitizers for Photodynamic Therapy: Cancer Research and Treatment—From Benchtop to Clinical Practice

A structure-activity relationship analysis of anthraquinones with antifouling activity against marine biofilm-forming bacteria

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