Anthraquinones from Ophiorrhiza pumila tissue and cell cultures

Kitajima, Mariko; Fischer, Ute; Nakamura, Masami; Ohsawa, M.; Ueno, Masahiro; Takayama, Hiromitsu; Unger, Matthias; Stöckigt, Joachim; Aimi, Norio

doi:10.1016/s0031-9422(97)00614-6

Cited by 53 publications

(19 citation statements)

References 30 publications

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“…14) However, the present study revealed the presence of eight anthraquinones in the wild plants of O. hayatana collected in Taiwan. All the anthraquinones identified from Ophiorrhiza so far were only substituted in the C-ring, except ophiohayatone-A (1) from the O. hayatana, with monosubstituted Aring.…”

Section: Resultscontrasting

confidence: 58%

“…[10][11][12][13] Although Ophiorrhiza belongs to the family Rubiaceae, few reports of anthroquinones were encountered from the hairy roots 12) and cell cultures. 14) As a part of our ongoing investigations on the secondary metabolites of Taiwan endemic plants, 15,16) we have investigated the whole plant of O. hayatana OHWI, a perennial erect herb growing in the low and medium elevations throughout Taiwan. 17) This paper deals with the isolation and structure elucidation of anthraquinones, named ophiohayatone-A, -B and -C.…”

mentioning

confidence: 99%

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Anthraquinones from Ophiorrhiza hayatana OHWI

Chan

Damu

2005

CHEMICAL & PHARMACEUTICAL BULLETIN

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Section: Resultscontrasting

confidence: 58%

mentioning

confidence: 99%

Anthraquinones from Ophiorrhiza hayatana OHWI

Chan

Damu

2005

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The known compounds 1-6 were readily identified by their spectral data and by comparison with reported corresponding compounds in the literature [12][13][14][15][16][17] as nordamnacanthal 1, damnacanthal 2, damnacanthol 3, lucidin-ω-ethyl ether 4, anthraquinone 5 and ursolic acid 6 (Figure 1).…”

Section: Resultsmentioning

confidence: 98%

Antimicrobial anthraquinones and triterpenoid isolated from Morinda geminata DC (Rubiaceae)

et al. 2017

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Morinda geminata DC is a plant of the traditional Senegalese pharmacopoeia, the leaves of which are used in the treatment of various diseases. The phytochemical investigation of its leaves and roots resulted in the isolation of the triterpenoid ursolic acid 6, and five known anthraquinones analogues: nordamnacanthal 1, damnacanthal 2, damnacanthol 3, lucidin-ω-ethyl ether 4, and anthraquinone 5. The isolated compounds were characterized by NMR and mass-spectrometry and were evaluated for their antimicrobial properties. Compounds 1 and 4 displayed significant antimicrobial activities towards Staphylococcus aureus. The present study constitutes the first phytochemical examination of the leaves and roots of Morinda geminata DC.

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“…Previously, the accumulation of anthraquinones has been reported in hairy roots and callus culture of O. pumila (Kitajima et al 1998). They are a major group of specialized metabolites in Rubiaceae family.…”

Section: Opmyb1 Involvement In Specialized Metabolisms Including Campmentioning

confidence: 99%

An MYB transcription factor regulating specialized metabolisms in <i>Ophiorrhiza pumila</i>

Rohani

Chiba

Kawaharada

et al. 2016

Plant Biotechnology

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Camptothecin is a plant-derived alkaloid and important precursor of clinically used anti-tumor drugs, but little is known about regulatory mechanism of camptothecin production in plants. We show here that a MYB transcription factor, OpMYB1, isolated from Ophiorrhiza pumila is a regulator of camptothecin biosynthesis. OpMYB1 has an EAR-like motif and exhibits a transcriptional repression activity in an in vivo assay using Arabidopsis thaliana leaves. Overexpression of OpMYB1 in hairy roots of O. pumila resulted in reduced production of camptothecin and reduced expression of OpTDC encoding triptophane decarboxylase catalyzing the earliest step in camptothecin biosynthesis. From the deep transcriptome analysis, GO enrichment in secondary (specialized) metabolisms, especially in phenylpropanoid pathway was observed in the hairy roots over-expressing OpMYB1. Furthuremore, gene suppression by OpMYB1 was revealed in biosynthetic pathways of seco-iridoids, monoterpene indole alkaloids, anthraquinone and chlorogenic acid. These results suggested that OpMYB1 is a negative regulator to fine-tune the general specialized metabolisms in O. pumila.

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Anthraquinones from Ophiorrhiza pumila tissue and cell cultures

Cited by 53 publications

References 30 publications

Anthraquinones from Ophiorrhiza hayatana OHWI

Anthraquinones from Ophiorrhiza hayatana OHWI

Antimicrobial anthraquinones and triterpenoid isolated from Morinda geminata DC (Rubiaceae)

An MYB transcription factor regulating specialized metabolisms in <i>Ophiorrhiza pumila</i>

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