Antimicrobial anthraquinones and triterpenoid isolated from Morinda geminata DC (Rubiaceae)

Abstract

<jats:p>Morinda geminata DC is a plant of the traditional Senegalese pharmacopoeia, the leaves of which are used in the treatment of various diseases. The phytochemical investigation of its leaves and roots resulted in the isolation of the triterpenoid ursolic acid 6, and five known anthraquinones analogues: nordamnacanthal 1, damnacanthal 2, damnacanthol 3, lucidin-ω-ethyl ether 4, and anthraquinone 5. The isolated compounds were characterized by NMR and mass-spectrometry and were evaluated for their antimicrobial properties. Compounds 1 and 4 displayed significant antimicrobial activities towards Staphylococcus aureus. The present study constitutes the first phytochemical examination of the leaves and roots of Morinda geminata DC.</jats:p>

Trichomonicidal activity of a new anthraquinone isolated from the roots of Morinda panamensis Seem

“…Diverse therapeutic activities of Morinda ‐isolated anthraquinones have been reported, some of which include anti‐inflammatory, antioxidant, anticancer, and antimicrobial activity. Nonetheless, the majority of the reports correspond to M. citrifolia (Abu et al, ; Gassama et al, ; Ismail, Mohamad, Mohidin, & Lajis, ; Zahin, Aqil, Khan, & Ahmad, ). Morinda panamensis , an American endemic specie, has been closely related to M. citrifolia by phytotaxonomic studies; however, there have not been many reports on the phytochemical constituents or bioactive properties associated with this plant.…”