Vegetation plays an important role in linking water, atmosphere, and soil. The dynamic change in vegetation is an important indicator for the regulation of the terrestrial carbon balance and climate change. This study applied trend analysis, detrended correlation analysis, and the Hierarchical Partitioning Algorithm (HPA) to GIMMS NDVI3g data, meteorological data, and natural vegetation types for the period 1983 to 2015 to analyze the temporal and spatial changes in NDVI during the growing season and its driving factors in the arid region of northwestern China. The results showed that: (1) the growing season length (GSL) was delayed, with a regional trend of 8 d/33 a, due to a significant advancement in the start of the growing season (SOS, −7 d/33 a) and an insignificant delay to the end of growing season (EOS, 2 d/33 a). (2) The regional change in NDVI was mainly driven by temperature and precipitation, contributing to variations in NDVI of forest of 36% and 15%, respectively, and in the NDVI of grassland, of 35% and 21%, respectively. In particular, changes to forested land and medium-coverage grassland (Mgra) were closely related to temperature and precipitation, respectively. (3) The spatial distribution of the mean NDVI of forest was closely related with precipitation, temperature, and solar radiation, with these meteorological variables explaining 20%, 15%, and 10% of the variation in NDVI, respectively. Precipitation and solar radiation explained 29% and 17% of the variation in the NDVI of grassland, respectively. The study reveals the spatial–temporal evolution and driving mechanism of the NDVI of natural vegetation in the arid region of Northwest China, which can provide theoretical and data support for regional vegetation restoration and conservation.