Anthropometric and metabolic pattern in obese Egyptian children: its association with C-reactive protein

Mohamed, Nageh Shehata; Maher, Sheren Esam; Abozaid, Samah Mohammed Mahmoud; Moenes, Hend

doi:10.1186/s43054-020-00030-2

Cited by 6 publications

(5 citation statements)

References 17 publications

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“…Our work revealed that no substantial variation was existed among obesity in children and controls in SBP and DBP (mmHg) and this agreed with Mohamed et al, [17] study. While Tanaka et al [18] discovered that obesity in children substantially greater in diastolic and systolic blood pressure contrasted to their controls.…”

Section: Discussionsupporting

confidence: 93%

Selenoprotein-p as Biomarker of Selenium Status in Obese Children and Adolescents

Mahmoud,

Elshafiey,

Elsharaby

et al. 2023

AJPR

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Background: The child and adolescent obesity have become a major public health problem. Selenoprotien p1 (SEPP1) is widely acknowledged to be among the most delicate functional indicators of Se status and it plays a role in the metabolism of Se and in anti-oxidative defense. So, we aimed to assess Selenoprotein-p level in obese children and adolescents. Methods: This cross-sectional comparative work included 60 children: 30 obese children and the control group consisted of 30 children who were healthy and matched in terms of gender and age. A comprehensive taking of history and clinical assessment with anthropometric measurements were conducted on all children and adolescents. Basic investigations and serum selenoprotien-p1 level were performed. Results: Serum selenoprotien-p1 (SEPP1) levels were substantially decreased in obese children contrasted to controls. Conclusions: Selenoprotien p1 levels were substantially decreased in obese children and adolescent. Selenoprotien p1 could be a sensitive functional biomarker of selenium status.

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Section: Discussionsupporting

confidence: 93%

Selenoprotein-p as Biomarker of Selenium Status in Obese Children and Adolescents

Mahmoud,

Elshafiey,

Elsharaby

et al. 2023

AJPR

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“…Regarding the lipid profile in our work before therapy, in both obese groups A and B, total cholesterol, LDL-C, and triglyceride level was significantly increased, and the HDL-C level was significantly reduced than those of controls. Our results agreed with Nogueira-de-Almeida and Mello, Milyani and Al-Agha, and Mohamed et al [39][40][41]. After therapy in groups A and B, the levels of total cholesterol, LDL-C, and triglycerides decreased significantly and became lower than before the intervention, while the level of HDL-C increased and became higher than before the therapy.…”

Section: Discussionsupporting

confidence: 91%

Effect of Omega-3 Polyunsaturated Fatty Acids Combined with Dietary Intervention on Childhood Obesity and Insulin Resistance

Seif,

Hamam,

El-Shafiey

et al. 2023

JAMMR

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Background: Obesity is one of the multifactorial diseases associated with numerous cardiometabolic comorbidity conditions and insulin resistance (IR). Modifying the lifestyle, like following healthy nutrition in addition to physical activity, is considered one of the main strategies for obesity management. Besides various treatment options, omega-3 polyunsaturated fatty acids (PUFAs) supplementation is suggested as a potential solution to alleviate several obesity-related issues. The work aimed: to assess the effects of omega-3 PUFAs in combination with dietary intervention on BMI and IR in children with obesity. Subjects and Methods: A prospective randomized controlled longitudinal study was carried out on sixty children & adolescents suffering from obesity with a BMI of ≥95th percentile for sex and age. They were categorized into 2 groups (thirty children in each group): group A received oral omega-3 PUFAs in addition to a dietary intervention for six months, and group B received only a dietary intervention during the same period. Another thirty healthy children & adolescents having BMI ranging from 5th to 85th percentile for sex and age were matched with the obese children groups for sex and age and served as controls. All participants included in the study underwent a history taking, thorough clinical assessment, anthropometric measurement, and various investigations such as ALT, AST, CRP, lipid profile, HOMA-IR, serum adiponectin, serum leptin, and adiponectin-leptin ratio (ALR). Results: After the therapeutic interventions, group A (omega-3-supplemented) showed significant improvement in waist circumference, serum triglycerides, HDL-C, inflammatory adipokines (that included leptin, adiponectin, and ALR) as well as markers for insulin sensitivity compared to group B. Conclusion: Combining omega-3 PUFAs with dietary intervention improved various obesity-related parameters, enhancing insulin sensitivity markers and reducing inflammatory adipokines in obese children and adolescents.

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“…The prevalence of dyslipidemia among obese children was estimated at 48.8% in studies from Europe and 63% in studies from South America [ 46 ]. We found higher levels of serum LDL-C and triglycerides and a lower HDL-C level in obese and overweight children as compared to the normal weight group, thus confirming findings from previous studies [ 9 , 10 , 19 , 47 , 48 , 49 ].…”

Section: Discussionsupporting

confidence: 91%

Comparison between School-Age Children with and without Obesity in Nutritional and Inflammation Biomarkers

Kassem

Na’amnih

Shapira

et al. 2022

JCM

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Childhood obesity is a major health problem. We examined differences between children with obesity and normal weight in nutritional and inflammation biomarkers. A cross-sectional study was conducted among healthy children aged 10–12 years from Arab villages in Israel. Parents were interviewed regarding sociodemographic and children’s health status. Body weight and height measurements were performed and weight categories were defined using the 2007 WHO growth curves. Blood samples were tested for complete blood count, levels of iron, ferritin, lipids, uric acid, and C-reactive protein (CRP). Overall, 146 children (59.0% males, mean age = 11.3 [SD = 0.5]) were enrolled. In total 43.8%, 14.1% and 42.3% of the participants had normal weight, overweight and obesity, respectively. A multivariable logistic regression model showed that children with overweight and obesity had lower iron, and HDL-C levels than children with normal weight. Levels of CRP, uric acid, LDL-C and lymphocytes were higher among children with overweight and obesity. In conclusion, our findings highlight the worse metabolic and nutritional status in overweight and obese children. Such markers play a role in metabolic syndrome, thus suggesting that metabolic syndrome might start in childhood.

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Anthropometric and metabolic pattern in obese Egyptian children: its association with C-reactive protein

Cited by 6 publications

References 17 publications

Selenoprotein-p as Biomarker of Selenium Status in Obese Children and Adolescents

Selenoprotein-p as Biomarker of Selenium Status in Obese Children and Adolescents

Effect of Omega-3 Polyunsaturated Fatty Acids Combined with Dietary Intervention on Childhood Obesity and Insulin Resistance

Comparison between School-Age Children with and without Obesity in Nutritional and Inflammation Biomarkers

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