Background Obesity is the most common chronic metabolic disease in children. The global prevalence of obesity has doubled from 1990 to 2015. Worryingly, the increase is more in children than adults. It has reached epidemic ranges and is a significant global problem. High-sensitivity C-reactive protein (hs-CRP) is a parameter that is used to assess inflammation and risk factor for cardiovascular events. Some reports describe an association between hs-CRP and obesity. The objective of the study is to evaluate anthropometric and metabolic parameters in obese Egyptian children and correlate them with hs-CRP level. Results For anthropometric variables, they were significantly higher in obese group than normal weight except for height (P value 0.001). A significant difference was reported for all lipid profile parameters between obese and normal-weight groups (P value 0.001). Also, CRP showed a positive correlation with both BMI as well as total cholesterol, while no correlation was observed with other parameters of obesity (r: 0.41, 0.29 respectively). Conclusion Elevated CRP may have a role in predicting altered lipid metabolism in obese children and this raises the possibility of cardiovascular diseases. Hence, preventive measures to control obesity is necessary.

Introduction: Most neonatal hyperbilirubinemia is benign, but because of the potential toxicity of bilirubin, neonates should be monitored to identity those who might develop severe hyperbilirubinemia. Objective: To determine if the cord blood hydrogen peroxide level can be used as an early predictor of neonatal hyperbilirubinemia or not and if there is a correlation between its levels and the severity of hyperbilirubinemia. Methods: This is a prospective comparative study included 59 full term neonates. Forty-one neonates developed jaundice (group I) and 18 neonates did not develop jaundice (group II) as controls. For all studied groups, we measured the cord blood bilirubin using modified diazo method and hydrogen peroxide levels using ELISA Kits and we measured their levels at 5 th and 7 th days of life for patients. Results: The cord blood H 2 O 2 levels as well as the bilirubin levels were higher in patients than controls. Significant positive correlations between cord blood H 2 O 2 and cord blood bilirubin levels were present (r=0.81& p<0.001), bilirubin levels at the 5 th day of life (r=0.46& p<0.001) and bilirubin levels at the 7 th day (r=0.60 & p<0.001). Moreover, there was a significant positive correlation between the 5 th day H 2 O 2 and the 5 th day bilirubin levels (r=0.75& p<0.001) and a strong significant correlation between 7 th day H 2 O 2 and 7 th day bilirubin (r=0.94 & p= 0.001). The sensitivity of the cord blood H 2 O 2 in cases as a predictor to neonatal hyperbilirubinemia was 92.6% and the specificity was100% with a cutoff point >35 (p-value 0.001). Conclusion: Cord blood hydrogen peroxide (H 2 O 2) levels can be used as an early predictor of neonatal indirect hyperbilirubinemia and can determine which neonates should be followed after discharge from the hospital.