Anti 70 kDa heat shock protein antibodies in sera of patients affected by autoimmune and non-autoimmune thyroid diseases.

Paggi, A; Prima, M. A. Di; Paparo, B.S.; Pellegrino, C.; Faralli, A. R.; Sinopoli, MT; Leri, O

doi:10.3109/07435809509030473

Cited by 13 publications

(8 citation statements)

References 7 publications

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“…Several groups detected the humoral immune reactivity against hsp70 in rheumatoid arthritis [48] and other autoimmune disorders like lupus erythematosus [21], immune thrombocytopenic purpura [49], autoimmune inner ear disease [50], thyroid autoimmune processes [51] and autoimmune liver disease [52].…”

Section: Discussionmentioning

confidence: 99%

Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis

Zlacka

Vavrincová

Nguyen

et al. 2006

Journal of Autoimmunity

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Section: Discussionmentioning

confidence: 99%

Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis

Zlacka

Vavrincová

Nguyen

et al. 2006

Journal of Autoimmunity

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“…T-cell reactivity against hsp60 present on Salmonella typhimurium is thought to cause reactive arthritis because of crossreactivity (173). A link with thyroid autoimmunity may be suggested by the observation that Graves' disease patients have higher levels of anti-hsp72 antibodies than controls (87,174). Another explanation linking autoimmunity to bacterial infections is the release of sequestered antigens by local infection and inflammation (175).…”

Section: Bacterial Infectionsmentioning

confidence: 99%

The environment and autoimmune thyroid diseases

2004

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Genetic factors play an important role in the pathogenesis of autoimmune thyroid disease (AITD) and it has been calculated that 80% of the susceptibility to develop Graves' disease is attributable to genes. The concordance rate for AITD among monozygotic twins is, however, well below 1 and environmental factors thus must play an important role. We have attempted to carry out a comprehensive review of all the environmental and hormonal risk factors thought to bring about AITD in genetically predisposed individuals. Low birth weight, iodine excess and deficiency, selenium deficiency, parity, oral contraceptive use, reproductive span, fetal microchimerism, stress, seasonal variation, allergy, smoking, radiation damage to the thyroid gland, viral and bacterial infections all play a role in the development of autoimmune thyroid disorders. The use of certain drugs (lithium, interferon-a, Campath-1H) also increases the risk of the development of autoimmunity against the thyroid gland. Further research is warranted into the importance of fetal microchimerism and of viral infections capable of mounting an endogenous interferon-a response.European Journal of Endocrinology 150 605-618

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“…Cellular levels of HSP-90 and HSP-70 in the thyroid gland are known to be linked to homeostasis (Wallin et al, 1992) and levels of cytotoxicity in certain glandular pathologies (Samadi et al, 2009; Paggi et al, 1995). These proteins may be biomarkers for detecting toxicity or environmental stress that affects normal thyroid tissue functioning.…”

Section: Introductionmentioning

confidence: 99%

Electromagnetic fields at 2.45 GHz trigger changes in heat shock proteins 90 and 70 without altering apoptotic activity in rat thyroid gland

Agustiño

Leiro²,

Mora

et al. 2012

Biology Open

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SummaryNon-ionizing radiation at 2.45 GHz may modify the expression of genes that codify heat shock proteins (HSP) in the thyroid gland. Using the enzyme-linked immunosorbent assay (ELISA) technique, we studied levels of HSP-90 and HSP-70. We also used hematoxilin eosin to look for evidence of lesions in the gland and applied the DAPI technique of fluorescence to search for evidence of chromatin condensation and nuclear fragmentation in the thyroid cells of adult female Sprague-Dawley rats. Fifty-four rats were individually exposed for 30 min to 2.45 GHz radiation in a Gigahertz transverse electromagnetic (GTEM) cell at different levels of non-thermal specific absorption rate (SAR), which was calculated using the finite difference time domain (FDTD) technique. Ninety minutes after radiation, HSP-90 and HSP-70 had decreased significantly (P<0.01) after applying a SAR of 0.046±1.10 W/Kg or 0.104±5.10−3 W/Kg. Twenty-four hours after radiation, HSP-90 had partially recovered and HSP-70 had recovered completely. There were few indications of lesions in the glandular structure and signs of apoptosis were negative in all radiated animals. The results suggest that acute sub-thermal radiation at 2.45 GHz may alter levels of cellular stress in rat thyroid gland without initially altering their anti-apoptotic capacity.

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Anti 70 kDa heat shock protein antibodies in sera of patients affected by autoimmune and non-autoimmune thyroid diseases.

Cited by 13 publications

References 7 publications

Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis

Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis

The environment and autoimmune thyroid diseases

Electromagnetic fields at 2.45 GHz trigger changes in heat shock proteins 90 and 70 without altering apoptotic activity in rat thyroid gland

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