Anti‐A₁ Le^b in Serum of a Person of a Blood Group A₁h

Abstract

Abstract. An antibody, anti‐A1 Leb, has been found in the serum of a person belonging to group A1h, with complete depression of H on the red cells as well as in the saliva. It differs from earlier examples of the antibody in that it can be neutralized by A1 nL, secretor saliva as well as O Leb secretor saliva in addition to A1 Leb secretor saliva. Although the proposita secretes A substance, she only secretes Lea substance and not Leb substance. No such abnormalities were found in the family investigated. An interpretation of the case is given according to the classical hypothesis of ABO and Lewis system development.

Further observations on the Birmingham chimaera.

“…Red cells coated with AlLeb are agglutinated by an antibody anti-AiLeb which does not agglutinate cells coated with either A1 or Leb alone (Seaman, Chalmers, and Franks, 1968;Crookston, Tilley, and Crookston, 1970;Gundolf, 1973).…”