Anti-ageing potential of carnosine: approaches toward successful ageing

Kyriazis, Marios

doi:10.1016/j.ddstr.2011.01.002

Cited by 8 publications

(15 citation statements)

References 38 publications

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“…Found in many high-protein foods such as meat, fish, eggs and dairy products, NAC is also available from the intake of various plant sources, such as broccoli and garlic. Manufactured naturally, NAC, is reported to be an effective dietary supplement used in the support and maintenance of a healthy skin functioning and antioxidant system balance [18] . Therefore, we used the general mitochondria-targeted ROS antagonist NAC to ascertain whether mitochondria were a major source of ROS in WLRE-treated skin cells.…”

Section: Discussionmentioning

confidence: 99%

Protection on Skin Aging Mediated by Antiapoptosis Effects of the Water Lily (Nymphaea Tetragona Georgi) via Reactive Oxygen Species Scavenging in Human Epidermal Keratinocytes

Park¹,

Sim²,

Lee³

et al. 2016

Pharmacology

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Aims: The water lily (WL) is found in Europe, Asia, and North America. WL reportedly has various pharmacological activities that improve the activities of daily life in humans. To our knowledge, no previous study has investigated about the aspect of protection on skin aging due to the mitochondria-mediated antiapoptosis effects of WL rhizome extract (WLRE) on human epidermal keratinocytes. Methods: Human epidermal keratinocytes cells were treated with WLRE (100, 200, and 400 μg/ml) for 1 h and then with ultraviolet radiation B (UVB) (50 mJ/cm²) for another 23 h. The levels of lactate dehydrogenase, reactive oxygen species (ROS), MitoTracker, caspase-3, and glutathione were analyzed spectrophotometrically. Also, the levels of B-cell lymphoma 2 (Bcl-2) family proteins were determined with immunohistochemistry or western blotting. Results: We investigated the protective effects of WLRE against UVB-induced mitochondria-mediated apoptosis. WLRE significantly and concentrations-dependently reduced UVB-induced apoptotic cytotoxicity. Furthermore, WLRE decreased ROS generation, mitochondrial dysfunction, Bcl-2-associated X protein levels, and cytochrome c release from mitochondria while increasing Bcl-2 protein levels as assessed. Moreover, WLRE inhibited caspase-3 activity and expression, indicating the inhibition of the apoptotic cascade, and induced increased levels of total glutathione, heme oxygenase 1, and radical-scavenging activity. Conclusion: Together, these results demonstrate that WLRE can protect human epidermal keratinocytes against UVB-induced mitochondria-mediated apoptosis by regulating ROS-eliminating pathways.

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Section: Discussionmentioning

confidence: 99%

Protection on Skin Aging Mediated by Antiapoptosis Effects of the Water Lily (Nymphaea Tetragona Georgi) via Reactive Oxygen Species Scavenging in Human Epidermal Keratinocytes

Park¹,

Sim²,

Lee³

et al. 2016

Pharmacology

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“…It is a strong antioxidant substance, being able to scavenge reactive oxygen species (ROS) and products of lipid peroxidation, such as unsaturated aldehydes, and also possessing strong anti-glycating capabilities. Over the past 20 years, studies have shown it to have many important roles in several processes, such as cytosolic buffering, immunomodulation, and neurotransmission [10][11][12]. Carnosine has been shown to exert a neuroprotective effect when applied before or after an episode of global-brain ischemia [13].…”

Section: B Herculano Et Al / Carnosine Rescues Cognitive Declinementioning

confidence: 99%

β-Alanyl-L-Histidine Rescues Cognitive Deficits Caused by Feeding a High Fat Diet in a Transgenic Mouse Model of Alzheimer's Disease

Herculano

Tamura

Ohba

et al. 2013

JAD

118

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Abstract. Our goal in this study was to determine whether or not feeding young (4 months old) Alzheimer's disease model transgenic mice with a high fat diet (HFD), consisting of 32% fat, is capable of causing cognitive decline and whether treatment with ␤-alanyl-L-histidine (carnosine) is capable of reducing these effects. Carnosine is an endogenous antioxidant and antiglycating agent that is abundantly present in the brain and muscle tissues of vertebrates. After 8 weeks of feeding with HFD, we observed a significant decline in the contextual memory in transgenic mice fed with HFD as compared to transgenic mice fed with a normal diet as well as to normal diet-wild type mice. Treatment with carnosine at a dose of 5 mg/day for 6 weeks was effective in preventing cognitive decline, as the transgenic group fed with HFD and treated with carnosine displayed a level of cognition comparable to controls. No differences in senile plaque load were observed between all groups. However, we observed an increase in the expression of RAGE in blood vessels as well as increased microglial activation in the hippocampus of animals fed with HFD, effects that were reversed when treated with carnosine. Given these results, there is a possibility that inflammation and cerebrovascular abnormalities might be the cause of cognitive decline in this model.

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“…CN2 accounts for a significantly smaller fraction of the dipeptide's breakdown in humans (Derave et al, 2010). In contrast, carnosine is found in all excitable tissues of the human body, including brain, myocardium, and skeletal muscle (Kyriazis, 2010), however, 99% of the body's carnosine is present in the muscle (Derave et al, 2010). In mammals, only skeletal muscle and olfactory bulb present millimolar concentration range of carnosine while brain regions, other tissues and body fluids have 10-to 1,000-fold lower concentration (Boldyrev et al, 2013).…”

Section: Chemical Characterizationmentioning

confidence: 98%

“…Carnosine and its precursor β-alanine both exhibit a robust list of health benefits including antioxidant activity, metal chelating, interaction with lipid peroxidation end products, anti-glycation activity, prevention of protein crosslinking, carbonyl group scavenging, reduction of diabetic pathologies, anti-inflammatory activity, and prevention of senile cataracts (Bauchart et al, 2007;Kyriazis, 2010). Table 2 summarizes the anti-oxidant, anti-glycation and anti-inflammation activity of carnosine as well as the health performance associated with the intake of carnosine.…”

Section: Heath Benefitsmentioning

confidence: 99%

“…The abnormal proteins proceed to crosslinking into larger complexes of dysfunctional proteins and the accumulation of such cross-linked glycated proteins subsequently leads to the formation of advanced glycation end products (AGEs). AGEs react in turn with reactive oxygen species, which leads to the development of age-related chronic degenerative diseases (Kyriazis, 2010). When proteins undergo glycation or oxidation, damage occurs in the amino acid side groups, during which carbonyl groups are being formed.…”

Section: Heath Benefitsmentioning

confidence: 99%

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Carnosine—a natural bioactive dipeptide: bioaccessibility, bioavailability and health benefits

Xing¹,

Chee²,

Zhang³

et al. 2019

Journal of Food Bioactives

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Carnosine is a natural dipeptide synthesized by both vertebrate and invertebrate organisms and has functional properties that are specific to muscle and excitable tissues. Recent in vivo and in vitro studies have shown that carnosine presents metal chelating and antioxidant activities and has the ability to inhibit protein carbonylation and glycoxidation. This review describes the health benefits of carnosine in relation to its bioaccessibility, bioavailability and biochemical properties as well as providing the current state-of-the-art knowledge on the potential use of carnosine as a nutraceutical. The therapeutic potential of carnosine has also been investigated by a number of preclinical and clinical studies for diseases such as diabetes and its associated complications, as well as fatigue, ageing, and some neurological disorders. Altogether the current literature provides supportive evidence on the use of carnosine as a natural dietary supplement with significant health boosting efficiency and without any side effects.

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Anti-ageing potential of carnosine: approaches toward successful ageing

Cited by 8 publications

References 38 publications

Protection on Skin Aging Mediated by Antiapoptosis Effects of the Water Lily (<b><i>Nymphaea Tetragona</i></b> Georgi) via Reactive Oxygen Species Scavenging in Human Epidermal Keratinocytes

Protection on Skin Aging Mediated by Antiapoptosis Effects of the Water Lily (<b><i>Nymphaea Tetragona</i></b> Georgi) via Reactive Oxygen Species Scavenging in Human Epidermal Keratinocytes

β-Alanyl-L-Histidine Rescues Cognitive Deficits Caused by Feeding a High Fat Diet in a Transgenic Mouse Model of Alzheimer's Disease

Carnosine—a natural bioactive dipeptide: bioaccessibility, bioavailability and health benefits

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