Anti-aging Effect of DX-9386 in Senescence Accelerated Mouse.

Zhang, Yongxiang; Takashina, Ken; Saito, Hiroshi; Nishiyama, Nobuyoshi

doi:10.1248/bpb.17.866

Cited by 30 publications

(14 citation statements)

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“…18) Hoelen, another component of Hachimi-jio-gan and Juzen-taiho-to, had anti-aging impact, prolonged the life span of SAM, prevented body weight decrease with aging and tended to improve the senile syndrome. 19) However, there have been no reports on the treatment or prevention of senile osteoporosis by these herbal medicines.…”

Section: )mentioning

confidence: 99%

Effects of Traditional Chinese Medicine on Bone Loss in SAMP6: A Murine Model for Senile Osteoporosis

Chen

Emura

Isono

et al. 2005

Biological & Pharmaceutical Bulletin

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In healthy adults, the amount of bone formation approximately balances the amount of bone resorption. In aged individuals, the balance shifts to favor bone resorption, which can result in debilitating diseases such as osteoporosis. Osteoporosis is a skeletal disorder characterized by compromised bone strength, and predisposes a person to an increased risk of fracture. Bone strength primarily reflects the integration of bone density and bone quality. 1)Osteoporosis is regarded as a heterogeneous disorder with multiple causes. It is roughly divided into two distinct types. Type I, known as postmenopausal osteoporosis, occurs in women after menopause. Type II, senile osteoporosis, occurs in both old men and women. Ovariectomy has been extensively used as an experimental model for postmenopausal osteoporosis, while senescence-accelerated mice P6 (SAMP6) can be used as a senile osteoporosis model.2) These mice exhibit a significant decrease in bone mineral density (BMD) and bone formation. It was demonstrated by using light microscopy and histomorphometric method that both osteoclastogenesis and osteoblastogenesis decreased in SAMP6.3) Recently, we found that the osteoblasts showed degenerative changes and the number of osteoblasts decreased, while the mast cells in bone marrows significantly increased in SAMP6 at 2 and 5 months of age. These findings indicated that the lower bone mass in SAMP6 was mainly due to the reduction of osteoblast formation. 4) However, the pathogenesis of senile osteoporosis has not fully been elucidated.Despite numerous investigations, the treatment and prevention of osteoporosis remain unsolved problems. Several agents such as estrogens and selective estrogen receptor modulators, bisphosphonates, calcitonin (CT) and parathyroid hormone (PTH) have been used clinically in the treatment of the disease. Traditional Chinese medicine has developed its own unique system during a period of 3000 years and has recently been reevaluated in the clinical field.5) Chinese medicines are known to have low toxicity and are suitable for long-term administration compared to chemically synthesized medicines. Several Chinese medicines are claimed to be effective in treatment of osteoporosis. By measuring BMD and serum hormone levels, Sassa et al. found that Hochu-ekki-to could elevate the serum level of ovarian hormone and prevent the bone loss in ovariectomized animals.6) Berberine, an isoquinoline alkaloid, could inhibit BMD decrease in both male and female SAMP6.7) It was morphologically demonstrated that Hachimi-jio-gan, Juzentaiho-to and Unkei-to were effective in preventing bone loss induced by ovariectomy in rats.8) However, no data are available as to the recovery of bone loss in SAMP6 by any of these Chinese medicines. In order to evaluate the effects of traditional Chinese medicine on senile osteoporosis, we examined whether Hachimi-jio-gan, Juzen-taiho-to or Unkei-to could prevent the bone loss in SAMP6. MATERIALS AND METHODS Traditional Chinese MedicinesDried extract powder of the traditional Chin...

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Section: )mentioning

confidence: 99%

Effects of Traditional Chinese Medicine on Bone Loss in SAMP6: A Murine Model for Senile Osteoporosis

Chen

Emura

Isono

et al. 2005

Biological & Pharmaceutical Bulletin

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“…11,12) Roots and rhizomes of Acorus calamus LINN (AC), commonly known as sweet flag, sweet grass and sweet cane (Family: Araceae), have been used in the Indian and Chinese systems of the medicine for hundreds of years for its beneficial role in improved learning performance, and its anti-aging effect. [13][14][15] Shukla et al reported that ethanolic extract of AC prevented acrylamide-induced hind limb paralysis, decreased GSH and GST, increased dopamine receptors in the corpus striatum.…”

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confidence: 99%

Protective Effect of Acorus calamus LINN on Free Radical Scavengers and Lipid Peroxidation in Discrete Regions of Brain against Noise Stress Exposed Rat

Manikandan

Srikumar

Parthasarathy

et al. 2005

Biological & Pharmaceutical Bulletin

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Exposure to continuous loud noise is a serious health problem due to excess production of oxygen free radicals. In medical research, more attention is paid to the antioxidant properties of medicinal plants to minimize the harmful effects of radicals. The aim of this study was to evaluate the protective effect of both ethyl acetate and methanolic extract of Acorus calamus LINN against noise stress (30 d, 100 dBA/4h/d) induced changes in the rat brain. We measured the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and the levels of reduced glutathione (GSH), vitamin C, vitamin E, protein thiols and lipid peroxidation (LPO) for the evaluation of oxidative stress status in discrete regions of the rat brain like cerebral cortex, cerebellum, pons-medulla, midbrain, hippocampus and hypothalamus. The results indicated that during exposure of noisy environment ROS generation led to increase in corticosterone, LPO and SOD, but decrease in CAT, GPx, GSH, protein thiols, vitamins C and E levels. Both the ethyl acetate and methanolic extract of Acorus calamus protected most of the changes in the rat brain induced by noise-stress.

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“…Extract of Ginko biloba enhance retention memory, in scopolamine-induced amnesia in both young and old rats and improved short-term memory in mice (Chopin and Briley, 1992;Petkov et al, 1993). DX-9386 (Chinese traditional prescription containing P. tenuifolia) improved motor activity, reduced lipid peroxidation, ameliorated memory impairment and prolonged the life span of senescence-accelerated mice in ethanol and scopolamine induced memory impairment in mice Zhang et al, 1994). Extract of Nelumbo nucifera improves retention memory by inhibiting acetylcholinesterase (AChE) activity in scopolamine-induced amnesia in rats (Oh et al, 2009).…”

Section: Plants Beneficial In Cognitive Declinementioning

confidence: 99%

Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer’s disease

Kumar

Sharma

Singh

et al. 2015

Mechanisms of Ageing and Development

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Anti-aging Effect of DX-9386 in Senescence Accelerated Mouse.

Cited by 30 publications

References 0 publications

Effects of Traditional Chinese Medicine on Bone Loss in SAMP6: A Murine Model for Senile Osteoporosis

Effects of Traditional Chinese Medicine on Bone Loss in SAMP6: A Murine Model for Senile Osteoporosis

Protective Effect of Acorus calamus LINN on Free Radical Scavengers and Lipid Peroxidation in Discrete Regions of Brain against Noise Stress Exposed Rat

Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer’s disease

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