Anti-Aging Effects of Monomethylsilanetriol and Maltodextrin-Stabilized Orthosilicic Acid on Nails, Skin and Hair

Abstract

Chemical form of silicon determines its absorption and bioavailability: particulate and polymerized forms exhibit minimal oral bioavailability, while monomers (maltodextrin-stabilized orthosilicic acid, M-OSA) and organic compounds (monomethylsilanetriol, MMST) may hypothetically be highly absorbed. This study aimed to investigate the dermatological effects of oral ingestion of silicon, either solid (M-OSA-SiliciuMax ® Powder) or liquid (MMST, SiliciuMax ® Liquid) on the skin, hair and nails of healthy volunteers, through a clinical trial (Registry number 2,032,724. Full protocol at Plataforma Brasil website). Patients were randomized to receive 5 mg of elemental Si, either M-OSA or MMST (group 1 and 2, n = 17 each) or placebo (group 3, n = 17) twice a day for 150 days. Clinical and patients' subjective evaluations were conducted. Multispectral face imaging and hair mineral analysis were also performed. Use of M-OSA and MMST provided significant (p < 0.05) betterment of facial wrinkles and UV spots. Changes were also observed at the end of the study in skin texture and length of eyelashes. Hair aluminum levels decrease with the treatments. Self-reported questionnaire indicated good satisfaction with both M-OSA and MMST. Continuous use of both M-OSA and MMST can provide improvements on skin parameters, as well as act as a detox agent for aluminum.

<p>Effects of Skin Lightening Cream Agents – Hydroquinone and Kojic Acid, on the Skin of Adult Female Experimental Rats</p>

“…1,2 Harmful products such as Hydroquinone, Kojic acid, and Mercury are present in many skin lightening products. 2,3 Hydroquinone is considered as a primary topical ingredient for inhibiting melanin production because it reduces the skin's production of melanin which is responsible for skin color. 4 However, because of the carcinogenic nature of hydroquinone, it has been banned in some countries in a bid to reduce the risks of skin cancer.…”

“…1 Apart from its effects on the skin, hydroquinone has been found to expose users to acute toxicity from oral exposure and it can also cause diseases such as thyroid disorder, leukemia, and liver damage. 1,3 Chronic occupational exposure to hydroquinone dust had reportedly resulted in eye injuries, which varied from mild irritation and staining of conjunctivae and cornea to changes in the thickness and curvature of the cornea, loss of corneal luster, and impaired vision. 5 Prolonged exposure could lead to the development of severe ocular effects.…”

Bioactive Compounds for Skin Health: A Review

“…Silicon (Si) is the second most abundant element on Earth, present in water, plants and animals [ 134 ] and it has semi-metallic properties. In nature, it is not normally found in free form but is usually present as a chemical compound of silicon dioxide, a complex compound, or silicon silicate [ 135 , 136 ]. The silicon present in food is solubilized in the acidic environment of the stomach, becoming easily absorbed orthosilicic acid (OSA) [ 134 ].…”

“…The silicon present in food is solubilized in the acidic environment of the stomach, becoming easily absorbed orthosilicic acid (OSA) [ 134 ]. Si is mainly absorbed from the diet [ 135 , 137 ] ( Table 1 ). Another important source of silicon used in dietary supplements is horsetail ( Equisetum arvense ) [ 134 ].…”

Topical monomethylsilanetriol can deliver silicon to the viable skin

“…Although it is not yet formally recognized as an essential mineral, its importance in nutrition and human health has been cumulatively evidenced for decades. For instance, there is clinical evidence of its positive role on skin surface and skin mechanical properties, as well as on brittleness of hair and nails , on bone and connective tissue health , on skin rejuvenation , on facial growth and UV spots , on hair growth and in the detoxification of aluminum .…”