Anti-aging food that improves markers of health in senior dogs by modulating gut microbiota and metabolite profiles

Gebreselassie, EE; Jackson, MI; Yerramilli, Maha; Jewell, DE

doi:10.1101/324327

Cited by 3 publications

(3 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In correlation with our results, in a human study, psyllium supplementation increased the fecal acetate concentration along with the amount of both succinate-specific utilizer Phascolarctobacterium and acetate metabolizing Faecalibacterium species [ 15 ]. Furthermore, according to other studies, increased fiber content of feed resulted in intensely elevated acetogenic bacterial content such as Ruminococcus , Phascolarctobacteria , Christensenellaceae and Ruminococcacea species in dogs [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to our results, it can be also concluded that only psyllium was able to increase the concentration of n-butyrate, which can be in correlation with the shift in the canine intestinal microbiota towards Faecalibacterium, Christensenellaceae, Oscillospira and Ruminococcus spp. as the effect of fiber-rich diet, described in previous studies, since these bacteria are able to effectively convert sugars, acetate and other substrates into n-butyrate [ 15 , 47 ]. On the other hand, according to recent studies, the composition of the intestinal microbiota of healthy humans was less altered by psyllium administration than that of constipated people [ 15 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Altered Intestinal Production of Volatile Fatty Acids in Dogs Triggered by Lactulose and Psyllium Treatment

Mackei

Talabér

Müller

et al. 2022

Veterinary Sciences

View full text Add to dashboard Cite

The intestinal microbiome of dogs can be influenced by a number of factors such as non-starch polysaccharides as well as some non-digestible oligo- and disaccharides. These molecules are only decomposed by intestinal anaerobic microbial fermentation, resulting in the formation of volatile fatty acids (VFAs), which play a central role in maintaining the balance of the intestinal flora and affecting the health status of the host organism. In the present study, the effects of lactulose and psyllium husk (Plantago ovata) were investigated regarding their influence on concentrations of various VFAs produced by the canine intestinal microbiome. Thirty dogs were kept on a standard diet for 15 days, during which time half of the animals received oral lactulose once a day, while the other group was given a psyllium-supplemented diet (in 0.67 and in 0.2 g/kg body weight concentrations, respectively). On days 0, 5, 10 and 15 of the experiment, feces were sampled from the rectum, and the concentration of each VFA was determined by GC-MS (gas chromatography–mass spectrometry). Lactulose administration caused a significant increase in the total VFA concentration of the feces on days 10 and 15 of the experiment (p = 0.035 and p < 0.001, respectively); however, in the case of psyllium supplementation, the concentration of VFAs showed a significant elevation only on day 15 (p = 0.003). Concentrations of acetate and propionate increased significantly on days 5, 10 and 15 after lactulose treatment (p = 0.044, p = 0.048 and p < 0.001, respectively). Following psyllium administration, intestinal acetate, propionate and n-butyrate production were stimulated on day 15, as indicated by the fecal VFA levels (p = 0.002, p = 0.035 and p = 0.02, respectively). It can be concluded that both lactulose and psyllium are suitable for enhancing the synthesis of VFAs in the intestines of dogs. Increased acetate and propionate concentrations were observed following the administration of both supplements; however, elevated n-butyrate production was found only after psyllium treatment, suggesting that the applied prebiotics may exert slightly different effects in the hindgut of dogs. These findings can be also of great importance regarding the treatment and management of patients suffering from intestinal disorders as well as hepatic encephalopathy due to portosystemic shunt.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Altered Intestinal Production of Volatile Fatty Acids in Dogs Triggered by Lactulose and Psyllium Treatment

Mackei

Talabér

Müller

et al. 2022

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…Encontram-se na literatura estudos que avaliaram o efeito de diversas dietas sobre a metabolômica, tanto em humanos (BEERMANN et al, 2003;BALDERAS et., 2010;WONG et al, 2012;PEREZ-CORNAGO et al, 2014) como em ratos (DINIZ et al, 2004;WANG et al, 2006), peixes (LIU et al, 2019), gatos (DENG et al, 2014), cães adultos (SCHMIDT et al, 2018) e cães idosos (GEBRESELASSIE et al, 2018).…”

Section: ôMega-3 E Metabolômicaunclassified

>b<Efeitos da suplementação de ácidos graxos poli-insaturados ômega-3 sobre a função cognitiva e metabolômica de cães em crescimento>/b<

Rodrigues¹

View full text Add to dashboard Cite

AGRADECIMENTOSÀ Deus, por me amar, me guiar e caminhar comigo, me dando oportunidade de ser melhor ao renascer de cada manhã e por ter colocado cada pessoa mencionada nesses agradecimentos em minha vida.Aos meus pais Clélia e Roberto por toda dedicação, apoio, esforço, amizade e correções, sem eles eu nada seria. Por serem meus exemplos, meu escudo e o meu porto seguro.Agradeço as minhas avós, Jandira e Maria Aparecida e avó de consideração Wilma que não se encontram mais conosco, mas estiveram comigo em boa parte da jornada, cada uma delas de forma especial, me ensinando um pouco da vida e se tornando exemplos que levarei para sempre comigo.Ao meu saudoso avô José (Zeca Bueno), que esteve comigo até o início do meu mestrado e se alegrou com minhas alegrias e conquistas, agradeço por toda preocupação, amor e risadas. Cada pedido dele para que eu me sentasse no sofá mais um pouco em sua casa enchia meu coração de alegria e hoje enche de saudades! Ao meu avô de consideração Roberto, no qual nunca me esquecerei do apoio que me deu juntamente com a vó Wilma desde o primeiro dia de faculdade. Suas lágrimas ao me deixar em Jaboticabal no primeiro dia de aula nunca permitiram que meu coração estivesse longe do coração deles.Aos meus tios Célia e Marcio, que com seu amor e compreensão me deram a oportunidade de estar onde estou e fazem parte de cada conquista obtida até aqui. À minha prima Franciellen, pelo apoio, ajuda, compreensão, que sempre esteve comigo desde criança e, nas horas mais difíceis foi meu abrigo independentemente de qualquer situação ao decorrer do meu mestrado. À minha prima Rafaela, que ao invés de prima é irmã, agradeço por toda preocupação, dedicação, apoio e amor, com quem eu pude e poderei contar para o resto da minha vida.Às minhas primas Carolina, Claudia, Gabrielli, Michelli, Pâmela, Letícia, Nayara e todos os demais primos por toda alegria e bons momentos que tornam minha vida mais alegre e divertida! Às minhas tias e tios, que cuidam de mim como filha, se preocuparam e me apoiaram em toda minha jornada até aqui, se tonando parte de todos meus processos e conquistas.Agradeço ao meu orientador por todas as oportunidades concedidas desde o primeiro momento, por ter aberto as portas e ter acreditado em mim, por ensinar e permitir que esse período da minha vida tenha se tornado inesquecível.Aos meus queridos amigos de trabalho, Mel, Larissa, Rafael, Mari Perini, Henrique, Andressa e Cati que estavam comigo no início da jornada. Agradeço pelos infinitos ensinamentos, conselhos, amizade, parceria, companhia, apoio, amor, suporte, compreensão, risadas e momentos que estarão comigo para sempre. Fizeram esse período da minha vida ser muito mais alegre, divertido e sem eles não seria a mesma coisa! Em especial, os meus agradecimentos aos grandes amigos Mel e Rafael, que não mediram esforços em me ajudar na realização desse projeto, abdicando de finais de semana, feriados, horários fora do expediente e noites de descanso.Agradeço ao meu recente amigo de trabalho Lucas, por todas as noites viradas logo de...

show abstract

The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health

2019

View full text Add to dashboard Cite

The Christensenellaceae, a recently described family in the phylum Firmicutes, is emerging as an important player in human health. The relative abundance of Christensenellaceae in the human gut is inversely related to host body mass index (BMI) in different populations and multiple studies, making its relationship with BMI the most robust and reproducible link between the microbial ecology of the human gut and metabolic disease reported to date. The family is also related to a healthy status in a number of other different disease contexts, including obesity and inflammatory bowel disease. In addition, Christensenellaceae is highly heritable across multiple populations, although specific human genes underlying its heritability have so far been elusive. Further research into the microbial ecology and metabolism of these bacteria should reveal mechanistic underpinnings of their host-health associations and enable their development as therapeutics.

show abstract

Anti-aging food that improves markers of health in senior dogs by modulating gut microbiota and metabolite profiles

Cited by 3 publications

References 52 publications

Altered Intestinal Production of Volatile Fatty Acids in Dogs Triggered by Lactulose and Psyllium Treatment

Altered Intestinal Production of Volatile Fatty Acids in Dogs Triggered by Lactulose and Psyllium Treatment

>b<Efeitos da suplementação de ácidos graxos poli-insaturados ômega-3 sobre a função cognitiva e metabolômica de cães em crescimento>/b<

The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health

Contact Info

Product

Resources

About