19Dysbiosis is one of the major changes in aging that leads to an accumulation of toxic microbial 20 metabolites. The aim of this study was to evaluate the effect of a test food containing components of 21 citrus, carrot, spinach and tomato on gut microbiota and age-related metabolites in senior dogs. The 22 study was conducted on 36 dogs between 8 and 13 years of age. All dogs were maintained on a control 23 food (control 1), which used corn as major source of fiber. After 30 days, the dogs were divided into sulfate. Christensenellaceae abundance was strongly associated with the observed health benefits. 37Fermentable fibers from fruits and vegetables enhance health in senior dogs by modulating the gut 38 bacteria and metabolites involved in aging, kidney, brain and gut health.

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