2012
DOI: 10.1111/all.12077
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Anti‐allergic action of anti‐malarial drug artesunate in experimental mast cell‐mediated anaphylactic models

Abstract: We report here for the first time that artesunate possesses anti-allergic activity by blocking IgE-induced mast cell degranulation, providing a foundation for developing artesunate for the treatment of allergic asthma and other mast cell-mediated allergic disorders.

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Cited by 55 publications
(38 citation statements)
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“…The mechanism by which artesunate inhibits the PI3K/Akt/p70 S6K pathway remains to be fully elucidated. Cheng's recent findings in mast cells suggest that Syk and phospholipase C g are potential targets of artesunate that are upstream of PI3K (30). Further investigation is warranted to determine whether these two proteins upstream of PI3K are involved in human ASM cell proliferation.…”
Section: Discussionmentioning
confidence: 99%
“…The mechanism by which artesunate inhibits the PI3K/Akt/p70 S6K pathway remains to be fully elucidated. Cheng's recent findings in mast cells suggest that Syk and phospholipase C g are potential targets of artesunate that are upstream of PI3K (30). Further investigation is warranted to determine whether these two proteins upstream of PI3K are involved in human ASM cell proliferation.…”
Section: Discussionmentioning
confidence: 99%
“…The IgE-mediated PCA model is also another well-characterized animal model of allergic reaction. Local injection of anti-DNP IgE followed by an intravenous antigenic challenge induces local plasma extravasation and vascular permeability [30] . In both animal models, the increase in histamine release results in vasodilation, which eventually causes hypothermia and Evans blue pigmentation.…”
Section: Discussionmentioning
confidence: 99%
“…[38][39][40][41][42] Artesunate is antagonistic with the formation of IgE and its mechanisms of action against parasites. 43,44 Worse even, a 5-fold increase in gametocytogenesis in Plasmodium falciparum has been documented for chloroquine in vitro. 45 It is shocking to read in a recent paper that while chloroquine may significantly reduce mortality, but whether it will interfere with the host immune system is currently unknown.…”
Section: 37mentioning
confidence: 99%