Anti-allergic effect of low molecular weight β-glucan prepared by λ-irradiation

Sung, Nak-Yun; Choi, Jong-il; Yoon, Yohan; Lee, Soo Young; Byun, Myung‐Woo; Hwang, Yeoung-Jung; Koenari, Zubaidah Irawati; Lee, Ju-Woon; Kim, Jae‐Hun

doi:10.1007/s10068-011-0117-3

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Among naturally-originated polysaccharides, branched β-(1,3)-D-glucan isolated from yeast cell walls has been widely applied in the food and pharmaceutical industries [ 27 , 28 , 29 ]. Since the native yeast β -glucan is high molecular weight and water-insoluble properties, the degradation of this product to a lower molecular weight and water-soluble form is more suitable for applications [ 30 , 31 , 32 , 33 ], including nanoparticle stabilization.…”

Section: Introductionmentioning

confidence: 99%

Radiation Synthesis of Selenium Nanoparticles Capped with β-Glucan and Its Immunostimulant Activity in Cytoxan-Induced Immunosuppressed Mice

Dung

Trong²,

Vu³

et al. 2021

Nanomaterials

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Selenium nanoparticles (SeNPs) with diameters from 64.8 to 110.1 nm were successfully synthesized by γ-irradiation of solutions containing Se4+ and water-soluble yeast β-glucan. The size and size distribution of SeNPs were analyzed by dynamic light scattering (DLS). Analytical X-ray diffraction (XRD) pattern results confirmed the crystal structure of the Se nanoparticles and Fourier transform infrared (FTIR) spectroscopy revealed that β-glucan could interact with SeNPs through steric (Se…O) linkages leading to a homogeneous and translucent solution state for 60 days without any precipitates. In vivo tests in cytoxan-induced immunosuppressed mice revealed that the daily supplementation of SeNPs/β-glucan at concentrations of 6 mg per kg body weight of tested mice significantly stimulated the generation of cellular immune factors (white blood cells, neutrophil, lymphocyte, B cells, CD4+ cells, CD34+ cells and natural killer cells) and humoral immune indexes (IgM, IgG, TNF-α, IFN-γ and IL-2) in peripheral blood, bone marrow and spleen of the immunosuppressed mice. The obtained results indicated that radiation-synthesized SeNPs/β-glucan may be a candidate for further evaluation as an agent for the prevention of immunosuppression in chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Radiation Synthesis of Selenium Nanoparticles Capped with β-Glucan and Its Immunostimulant Activity in Cytoxan-Induced Immunosuppressed Mice

Dung

Trong²,

Vu³

et al. 2021

Nanomaterials

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“…β -glucan isolated from yeast has been demonstrated to stimulate responses, tolerance to oral antigens, and antimicrobial activity in animals [8,9,10,11,12]. Furthermore, β -glucan has been proven to have the ability to reduce glucose absorption in diabetic animals [13,14], prevent allergic reactions in mice [15], and provide hematoprotection against acetaminophen-induced toxicity in mice [16]. According to Sima et al [17], both insoluble and soluble forms of this polymer are able to interact with lipids and biliary salts in the bowel, and consequently reduce cholesterol levels.…”

Section: Introductionmentioning

confidence: 99%

“…Although yeast β -glucan has been proven to have more biological activities than β -glucan prepared form other source [5], the high molecular weight (Mw) and water-insoluble properties of yeast β -glucan are major disadvantages for the application of these novel polymers. Recently, Sung et al [15,20] reported that degraded products of this natural polysaccharide with low molecular weight displayed stronger stimulation effects on immune activity in mice than those of native products with high molecular weight. In addition, Methacanon et al [21] reported that the efficacy of β-glucan as an interleukin-8 inducer is associated with its molecular weight, and the degradation β-glucans demonstrated higher activity in interleukin-8 production compared to non-degraded samples.…”

Section: Introductionmentioning

confidence: 99%

Radiation Degradation of β-Glucan with a Potential for Reduction of Lipids and Glucose in the Blood of Mice

Long

Ánh²,

Bach

et al. 2019

Polymers

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Water-soluble and low molecular weight (Mw) β-glucans were successfully prepared by γ-irradiation of water-insoluble yeast β-glucans. The radiation dose used for the degradation of yeast β-glucan was remarkably reduced by increasing the pH of the sample or combining with hydrogen peroxide treatment. Radiation-degraded β-glucans with molecular weights in the range of 11−48 kDa reduced the total cholesterol, triglyceride, low density lipoprotein (LDL) cholesterol, and glucose levels in the blood of administered mice. The decreasing levels of both lipid and glucose indexes in the blood of tested mice strongly depended on the molecular weight of the β-glucan, and the radiation-degraded β-glucan with a molecular weight of about 25 kDa was found to be the most effective for the reduction of blood lipid and glucose levels. Particularly, the oral administration of 25 kDa β-glucan, with a daily dose of about 2 mg per head, reduced the total cholesterol, triglyceride, LDL-cholesterol, and glucose levels in the blood of tested mice to about 47.4%, 48.5%, 45.7%, and 47.2%, respectively. The effects on the reduction of blood lipid and glucose levels were also found to be stable after 20 days of stopping administration. These results indicate that the degraded β-glucan with a molecular weight of about 25 kDa prepared by γ-ray irradiation is a very promising ingredient that can be used in nutraceutical food for therapeutics of diabetic and dyslipidemia.

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Synergic degradation of yeast β-glucan with a potential of immunostimulant and growth promotor for tiger shrimp

Luân¹,

Vu²,

Nghĩa³

et al. 2021

Aquaculture Reports

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Anti-allergic effect of low molecular weight β-glucan prepared by λ-irradiation

Cited by 3 publications

References 12 publications

Radiation Synthesis of Selenium Nanoparticles Capped with β-Glucan and Its Immunostimulant Activity in Cytoxan-Induced Immunosuppressed Mice

Radiation Synthesis of Selenium Nanoparticles Capped with β-Glucan and Its Immunostimulant Activity in Cytoxan-Induced Immunosuppressed Mice

Radiation Degradation of β-Glucan with a Potential for Reduction of Lipids and Glucose in the Blood of Mice

Synergic degradation of yeast β-glucan with a potential of immunostimulant and growth promotor for tiger shrimp

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