Anti-allergic Effects of Fermented Ixeris sonchifolia and Its Constituent in Mice

Abstract

To evaluate the antiallergic effect of fermented Ixeris sonchifolia (IS, family Compositae), we prepared IS kimchi, isolated lactic acid bacteria (LAB) from it, fermented IS with these LAB, and investigated their antiallergic effects. IS kimchi inhibited the passive cutaneous anaphylaxis (PCA) reaction induced by an IgE-antigen complex as well as the scratching behavior induced by compound 48/ 80 or histamine more potently than IS. When IS was fermented with LAB isolated from IS kimchi, its antiallergic effects was also increased. Of LAB used for fermentation, Lactobacillus brevis more potently increased the antiallergic effects. Its main constituents, chlorogenic acid and luteolin, potently inhibited the PCA reaction induced by the IgEantigen complex as well as the pruritis induced by compound 48/80 or histamine. These constituents inhibited the expression of proinflammatory and allergic cytokines, TNF-α and IL-4, and transcription factor NF-κB activation induced by the IgE-antigen complex in RBL-2H3 cells, as well as the degranulation of RBL-2H3 cells induced by the IgE-antigen complex. Luteolin more potently inhibited these allergic reactions than chlorogenic acid. These findings suggest that the antiallergic effect of IS can be increased by LAB fermentation, and the fermented IS might improve allergic reactions such as pruritus, anaphylaxis, and inflammation.

Prevention of Topical Surfactant^|^ndash;Induced Itch-Related Responses by Chlorogenic Acid Through the Inhibition of Increased Histamine Production in the Epidermis

“…Systemic administration of chlorogenic acid has been reported to cause partial inhibition of scratching induced by histamine and mast cell degranulation (6). A topical dose of 5% chlorogenic acid might not be enough to exert anti-histamine effects in the dermis.…”

“…Extracts of plants of Prunus species, especially cherry trees, have several pharmacological effects, including antiinflammatory, anti-hyperlipidemic, anti-hyperpigmentation, and antioxidant effects (4,5). It has been recently reported that systemic administration of chlorogenic acid, a main constituent of cherry leaves, exerts weak inhibitory activity on hind-paw scratching induced by histamine and plasma extravasation induced by passive cutaneous anaphylaxis in mice (6). Therefore, in the present study, we examined the effects of topical application of chlorogenic acid on sodium laurate-induced scratching and the mechanisms of anti-pruritic activity of topical chlorogenic acid.…”

Protective effect of total flavonoids from Ixeris Sonchifolia on herpes simplex virus keratitis in mice

“…In addition, there also some studies showed that ISH provide a neuroprotective effects against ischemiainduced cellular injury in vitro [13], and inhibition the cell proliferation in HepG2 human hepatocellular carcinoma cells [14]. More importantly, in animal model experiment, ISH showed a potent anti-allergic effects in mice model [15], anti-tumors in non-small cell lung cancer in animals [16], and anti-human hepatocellular carcinoma in mice model [14]. Furthermore, the constitutes study of the ISH showed that the main bioactivity component mainly contains flavonoid [17], sesquiterpene lactone [18,19], sesquiterpene lactone glucoside [20], triterpenoidal saponin [21][22][23] and etc..…”

Fermentation-Mediated Enhancement of Ginseng��s Anti-Allergic Activity against IgE-Mediated Passive Cutaneous Anaphylaxis In Vivo and In Vitro

“…The IgE receptor activates the JNK pathway through the MEKK2-MKK4/7 cascade [8,9]; this pathway is essential for the induced expression of some cytokine genes such as IL-4, IL-6, or TNF-α and is activated following antigenic mast cell activation [10,11]. These cytokine-induced reactions then cause tissue inflammation and anaphylaxis, both of which are becoming chronic health problems worldwide [12].…”