Anti-allergic effects of novel sulfated polysaccharide sacran on mouse model of 2,4-Dinitro-1-fluorobenzene-induced atopic dermatitis

A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment

“…Different polysaccharides have been reported to contain sugar molecules, such as galactose, rhamnose, fucose, and arabinose, acting as immune potentiators; and reported for their anti-coagulant, anti-HIV and anti-oxidant activities (47,(54)(55)(56)(57). Moreover, studies have also reported that polysaccharides can influence the immune response upon digestion by downregulating Th-2 cytokines and suppressing allergic inflammatory responses in the gut (17,(58)(59)(60)(61). A brief summary of these investigations is provided in Table 1.…”

“…Three major groups of marine algae: brown algae, red algae, and green algae, are the main sources of sulfated polysaccharides. Several recent reports have indicated that chemically active metabolites from marine algae can suppress allergen specific antibodies such as IgE, IgG, IgG1 by downregulating CD3, CD4, and CD8 cell surface receptors thereby attenuating the cytokine response (e.g., IL-4, IL-5, and IL-13), in both in vitro and in vivo models of allergy (17,(75)(76)(77)(78). Fucoidan is a sulfated polysaccharide commonly found in different brown algae species.…”

“…Furthermore, in vitro administration of sacran to B cells isolated from spleen cells demonstrated no proliferative effect. However, in vitro sacran treatment in primary mouse T cells and Jurkat T cells significantly inhibited the proliferation of T cells, exhibiting immunomodulatory potential (17). Porphyran and sacran, as reported for contact hypersensitivity, could be further explored for their immune modulating properties for food allergy.…”

“…Naturally occurring bioactive compounds have been extensively investigated in recent years for their immunomodulatory properties with the therapeutic potential to treat various human diseases including asthma, diabetes, and cancer ( 12 – 14 ). Bioactive compound sources such as marine algae, Chinese herbal medicine and traditional herbal medicines have been reported to be beneficial in modulating allergic responses ( 15 – 17 ). The natural abundance of different types of marine algae and herbal sources provides an array of options, making them a prime source for natural-product based therapeutic approaches ( 18 – 20 ).…”

The Use of Megamolecular Polysaccharide Sacran in Food and Biomedical Applications

“…Sacran has been developed as a wound dressing material as its activity in absorbing exudate and its characteristics are better for human skin in the wound healing process. This is due to its ability to expand and its high porosity [ 63 ]. The swelling degree of crosslinked sacran gel in pure water increases with pH.…”