Anti‐allergic effects of PG102, a water‐soluble extract prepared from Actinidia arguta, in a murine ovalbumin‐induced asthma model

Kim, D.; Kim, S. H.; Park, E. J.; Kang, Chang–Yuil; Cho, S. H.

doi:10.1111/j.1365-2222.2008.03124.x

Cited by 44 publications

(35 citation statements)

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“…These in vivo findings were also strongly supported by the data from various in vitro cell culture experiments [5, 7]. All these results suggested that PG102 might have preventive or therapeutic effects on a broad range of allergic diseases.…”

Section: Discussionsupporting

confidence: 76%

“…We have previously shown that PG102 could regulate the expression of IgE and Th1 and Th2 cytokines involved in the allergy pathogenesis, using the OVA-sensitized mouse, NC/Nga dermatitis mouse, magnesium-deficient hairless rat and OVA-induced asthmatic mouse models [5,6,7]. These in vivo findings were also strongly supported by the data from various in vitro cell culture experiments [5, 7].…”

Section: Discussionsupporting

confidence: 74%

“…It was subsequently found that oral administration of PG102 could improve asthma conditions in a murine model, probably by regulating the level of IgE and IL-5 [7]. In these experiments, PG102 was orally administrated after [5] or simultaneously with [6, 7] induction of the allergy. All these in vitro and in vivo data strongly suggested that PG102 might be an effective antiallergic agent for various allergic diseases.…”

Section: Introductionmentioning

confidence: 99%

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Suppression of Allergic Diarrhea in Murine Ovalbumin-Induced Allergic Diarrhea Model by PG102, a Water-Soluble Extract Prepared from Actinidia arguta

Kim

Park

et al. 2009

Int Arch Allergy Immunol

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Background: Allergic reactions to food can involve diarrhea, vomiting, nausea and abnormal pain. PG102 has previously been shown to control various factors involved in allergy pathogenesis, including IgE and various Th1 and Th2 cytokines, in vivo as well as in vitro [Park EJ, et al.: J Allergy Clin Immunol 2005;116:1151–1157; Park EJ, et al.: J Invest Dermatol 2007;127:1154–1160]. These data indicate that PG102 might have antiallergic effects on allergic diarrhea. Here, we investigated whether PG102 could prevent allergic diarrhea in the murine ovalbumin (OVA)-induced allergic diarrhea model. Methods: BALB/c mice were orally treated with PG102, dexamethasone or water for 9 days on a daily basis, followed by subcutaneous injection with OVA on day 0. Animals were orally administrated with OVA from day 7, 3 times a week, over a period of approximately 20 days. Incidence of diarrhea, serum, OVA-restimulated splenocytes and lamina propria lymphocytes were analyzed. Results: Oral administration of PG102 could suppress the incidence of diarrhea in a murine allergic diarrhea model. The amelioration of allergic diarrhea by PG102 was accompanied with the inhibition of mast cell infiltration into the large intestine. The serum level of IgE, IL-6 and MCP-1 was decreased in PG102-treated mice. When splenocytes were isolated from respective groups and cultured in the presence of OVA, cells from PG102-administrated animals produced lesser amounts of IL-6 and MCP-1. Conclusions: PG102 has the potential to be used as a preventive for food allergic diseases.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Suppression of Allergic Diarrhea in Murine Ovalbumin-Induced Allergic Diarrhea Model by PG102, a Water-Soluble Extract Prepared from Actinidia arguta

Kim

Park

et al. 2009

Int Arch Allergy Immunol

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“…PG102, an aqueous extract from Actinidia arguta (26), is an example exhibiting such an activity. White rose fetal extract of Rosa rugosa root (27), procyanidin C1 from apple (28), and hot water extract of Cydonia oblonga (29) have shown potential in inhibiting chemical-induced animal model or NC/Nga mice.…”

Section: Discussionmentioning

confidence: 99%

Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius

Lee¹

2011

Int J Mol Med

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Abstract.To evaluate whether an aqueous seed extract of Terminalia chebula Retzius inhibited development of atopy in vivo, we used a 2,4-dinitrofluorobenzene (DNFB)-induced animal model of atopic symptoms to investigate the effects of the extract. We measured CD4 + cell numbers by hematoxylin and eosin (H&E) staining, and determined the expression levels of matrix metalloproteinase (MMP)-9, interleukin (IL)-31, and T-bet genes, in this animal model. The data showed that a Terminalia chebula extract (100 µg/ml) exhibited strong anti-atopic activity, mediating a 52% reduction in the immune response, as measured by thickness of ear swelling, and resulting in decreased eosinophil levels in adjacent skin tissue. Collectively, the results indicate that a Terminalia chebula seed extract has potential for alleviation of atopy-like symptoms induced by DNFB in the mouse. IntroductionIt is generally accepted that the daily consumption of plantderived phytochemicals in vegetables, fruit, tea or herbal extracts may mitigate free-radical attacks (1-3). Terminalia chebula Retzius is an ethnopharmacological plant of India and Southeast Asia, and has traditionally been used as a laxative, a diuretic, and an anti-oxidative material (4-8). In addition, plant extracts have antibacterial (9,10), antiviral (11), antifungal (12) and immune modulatory activities (13,14). Recently, Lee et al (5,15) reported that an aqueous seed extract of Terminalia chebula Retzius (TcRSE) had potent anti-oxidant activity both in vitro and in vivo when tested as a hepatoprotective agent in an animal model. Atopic dermatitis is a major degenerative disease, which presents as a chronic inflammatory skin condition with a deficiency in barrier function (16). It is now well recognized that several proteases, including the matrix metalloproteinases (MMPs), play key roles in the immunopathology of and biological functions during progression of the disease (17). With limited exceptions, normal healthy skin does not contain or exhibit high levels of MMP activity. Thus, evaluation of enzyme activities is important in detection, prior to mitigation, of allergic reactions (18,19). However, little effort has been devoted to treatment of atopy-related disorders with natural extracts, and we thus prioritized the investigation of TcRSE as an inhibitor of anti-atopic dermatitis activity.In the present study, we initially sought immunomodulatory components in natural resources including foods and oriental herbs, and found that TcRSE was active in vitro (data not shown). We thus examined the ameliorating effects of TcRSE against 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis in mice. Biochemical and immunochemical analyses, including cytokine expression evaluation and phenotypic atopic symptoms, were performed to investigate whether TcRSE alleviated the disorder. Materials and methodsChemicals. MMP-9, anti-T-bet and interleukin (IL)-31 antiinterleukin (IL)-31 anti-IL)-31 antibodies were purchased from Cell Signaling (catalog no. 3852; Danvers, MA), Santa Cruz ...

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“…Kim et al reported that a water-soluble extract prepared from Actinidia arguta improved asthmatic symptoms via the down-regulation of IgE in mouse (5). Lee et al found that resveratrol, which has been identifi ed in various fruit and vegetable extracts, inhibited Th2-type cytokines such as IL-4 and IL-5, and suppressed airway hyperresponsiveness, eosinophilia, and mucus hypersecretion in an asthmatic mouse model (6).…”

mentioning

confidence: 99%

Anti-Allergic Properties of a Matured Fruit Extract of the Date Palm Tree (Phoenix dactylifera L.) in Mite-Sensitized Mice

Karasawa

Otani

2012

J Nutr Sci Vitaminol

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Anti‐allergic effects of PG102, a water‐soluble extract prepared from Actinidia arguta, in a murine ovalbumin‐induced asthma model

Abstract: PG102 may have potential as a safe and effective reagent for the prevention or treatment of asthma.

Cited by 44 publications

References 44 publications

Suppression of Allergic Diarrhea in Murine Ovalbumin-Induced Allergic Diarrhea Model by PG102, a Water-Soluble Extract Prepared from <i>Actinidia arguta</i>

Suppression of Allergic Diarrhea in Murine Ovalbumin-Induced Allergic Diarrhea Model by PG102, a Water-Soluble Extract Prepared from <i>Actinidia arguta</i>

Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius

Anti-Allergic Properties of a Matured Fruit Extract of the Date Palm Tree (Phoenix dactylifera L.) in Mite-Sensitized Mice

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