Anti-Allergic Effects of Vernonia amygdalina Leaf Extracts in Hapten-Induced Atopic Dermatitis-Like Disease in Mice

Abstract

Results from this report suggest that VAM extracts, known as ERK pathway inhibitor, prevent and improve atopic/eczema dermatitis syndrome.

PHYTOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF Vernonia amygdalina: A REVIEW

“…3.0 PHARMACOLOGICAL EFFECTS OF V. amygdalina V. amygdalina had been reported to possess several pharmacological effects like antimicrobial, antimalarial, antithrombotic, antioxidant, anti-diabetic, laxative, hypoglycemic, antihelmintic, anti-inflammatory, cathartic, anticancer, antifertility, antifungi, antibacterial, and among others (Igile et al, 1994;Akinpelu, 1999;Iwalokun et al, 2006;Erasto et al, 2007;Gresham et al, 2008;Khalafalla et al, 2009;Ilondu, 2010;Farombi and Owoeye, 2011;Anibijuwon et al, 2012;Ngatu et al, 2012;Adetunji et al, 2013;Atangwho et al, 2013;Akinyele et al, 2014;Ezeadila et al, 2015;Udochukwu et al, 2015;Alara et al, 2017c).…”

“…The extracts from V. amygdalina leaves had been reported to inhibit and prevent atopic or eczema dermatitis syndrome in mice (Ngatu et al, 2012).…”

“…Several studies carried out on this plant had suggested that it contains different bioactive compounds, including, flavonoids, saponins, alkaloids, tannins, phenolics, terpenes, steroidal glycosides, triterpenoids, and several types of sesquiterpene lactones (Erasto et al, 2006;Farombi and Owoeye, 2011;Kiplimo et al, 2011;Toyang and Verpoorte, 2013;Adedapo et al, 2014;Quasie et al, 2016;Luo et al, 2017). These bioactive compounds made them possess different pharmacological properties like antimicrobial, antimalarial, antithrombotic, antioxidant, anti-diabetic, laxative, hypoglycemic, antihelmintic, anti-inflammatory, cathartic, anticancer, antifertility, anti-fungi, antibacterial, and among others (Igile et al, 1994;Akinpelu, 1999;Iwalokun et al, 2006;Erasto et al, 2007;Gresham et al, 2008;Khalafalla et al, 2009;Ilondu, 2010;Farombi and Owoeye, 2011;Anibijuwon et al, 2012;Ngatu et al, 2012;Adetunji et al, 2013;Atangwho et al, 2013;Akinyele et al, 2014;Ezeadila et al, 2015;Udochukwu et al, 2015;Alara et al, 2017c). The objective of this review paper is to outline and discuss the studies that had been done on the bioactive compounds, phytochemical and pharmacological properties of V. amygdalina.…”

Atopic dermatitis-like disease in a rat model

“…Idealmente, o modelo animal utilizado para este tipo de estudo deve ser confiável, acessível e permitir quantificar os sintomas usualmente induzidos pela DA. Os modelos animais de DA existentes são geralmente explorados utilizando o dorso [5,16,18,19], abdômen e orelhas [20] de camundongos, assim somo o dorso de ratos Wistar [21]. Este último modelo animal tem sido estabelecido através de injeção subcutânea de capsaicina em ratos recém-nascidos dentro de 48h após o nascimento [21,22].…”

“…Ideally, the animal model used for this kind of study should be reliable, affordable and allow researchers to quantify the symptoms that are usually induced by AD. Existing animal models of AD are generally explored in mice dorsum [5,16,18,19], abdomen and ears [20] and also in Wistar rats' dorsal skin [21]. This last animal model has been established through subcutaneous injection of capsaicin into newborn rat pups within 48h of birth [21,22].…”