Anti-allergy properties of fermented foods: an important immunoregulatory mechanism of lactic acid bacteria?

Cross, Martin L.; Stevenson, Lesley; Gill, H. S.

doi:10.1016/s1567-5769(01)00025-x

Cited by 166 publications

(118 citation statements)

References 84 publications

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“…In fact, modulation of regulatory T cell subsets by anti-CD3 mAb or depletion of CD8 1 T cells by anti-CD8 mAb improved glucose metabolism in animals with high-fat diet-induced obesity (16,18). Probiotic bacteria are known to affect T cell function and to have antiallergic action (19,20). Further study is needed to show the contribution of T cell function in adipose tissue to the alteration of glucose metabolism in L. plantarum OLL2712-treated mice.…”

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confidence: 99%

Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

Sakai

Taki

Nakamoto

et al. 2013

J Nutr Sci Vitaminol

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SummaryThe aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 10 9 cfu heatkilled L. plantarum OLL2712 for 12 wk showed significant reduction of blood glucose levels in response to insulin. Furthermore, mRNA expression of interleukin-1b in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice. These results indicate that L. plantarum OLL2712 regulates glucose metabolism.

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confidence: 99%

Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

Sakai

Taki

Nakamoto

et al. 2013

J Nutr Sci Vitaminol

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“…13) Recent studies have shown the immunomodulation mechanism of lactobacilli for the beneficial effect on allergic disease model animals is apparently not confined to the simple notion of the restoration of the Th1/Th2 balance. For instance, Kwona et al 14) provided evidence that some lactobacilli might induce Foxp3 + regulatory T cells to have a beneficial effect on allergy and autoimmune diseases.…”

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confidence: 99%

Suppressive Effects of Oral Administration of Heat-Killed <i>Lactobacillus acidophilus</i> on T Helper-17 Immune Responses in a Bovine β-Lactoglobulin-Sensitized Mice Model

Li¹,

Meng²,

Duan³

et al. 2013

Biological & Pharmaceutical Bulletin

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The present study was planned to explore the effect of Lactobacillus (L.) acidophilus on the T helper-17 (Th17) immune response in a mouse model of β-lactoglobulin (β-lg) allergy. Bovine β-lg sensitised BALB/c mice were orally administered with different doses of heat-killed L. acidophilus (low, 5×10 7 colony forming unit (CFU); medium, 5×10 8 CFU; high, 5×10 9 CFU) in 200 µL of phosphate buffered saline (PBS) three times a week, starting from 1 week before β-lg sensitisation for 4 weeks. After the allergen challenge, the numbers of blood eosinophils and neutrophils were examined by light microscope; the levels of cytokine (interleukin (IL)-12, IL-4, tumor growth factor (TGF)-β, IL-10, IL-6 and IL-17A), total immunoglobulin E (IgE) and β-lg-specific IgE contents in the serum were measured with enzyme-linked immunosorbent assay (ELISA); The mRNA expression levels of TGF-β, IL-17A,CD25, Foxp3, retinoic acid-related orphan receptor γt (RORγt) and IL-10 were analyzed using real-time polymerase chain reaction (PCR). The results showed that oral administration of L. acidophilus suppressed hypersensitivity responses, attenuated the numbers of inflammatory cells and inhibited IgE production. We found up-regulation of TGF-β and down-regulation of IL-17A in the serum of L. acidophilus-treated group, along with IL-6 levels was significantly decreased than that of the allergy group (p<0.05). Moreover, the mRNA expression levels of CD25, forkhead box P3 and TGF-β were significantly higher in the spleen of L. acidophilus-treated group, while the mRNA expression levels of IL-17A, RORγt and IL-10 were significantly lower than that in the allergy group (p<0.05). In conclusion, the suppression of major allergic symptoms by oral administration of L.acidophilus was probably due to improve the regulatory T (Treg)/Th17 balance and inhibit the IL-6 production.

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“…In recent years, the proposed health benefit of probiotics has undergone increasingly rigorous scientific evaluation and, at present, strong evidences for their use in treating and preventing some human diseases have been proved. They are considered effective in the treatment of infantile diarrhoea, traveler's diarrhoea, and antibioticassociated diarrhoea, paucities, inflammatory bowel disease, urogenital infections, and ulcer (MORENO et al, 2006;MCFARLAND, 2007), and they are active to prevent food allergy and hypercholesterolemia (SALMINEN et al, 1998;CROSS;STEVENSON;GILL, 2001;SAARELA et al, 2002). Most probiotics in use today belong to the genera Lactobacillus and Bifidobacterium.…”

Section: Introductionmentioning

confidence: 99%

Survival of Lactobacillus rhamnosus probiotic strains in peach jam during storage at different temperatures

Randazzo¹,

Pitino²,

Licciardello³

et al. 2013

Food Sci. Technol (Campinas)

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Anti-allergy properties of fermented foods: an important immunoregulatory mechanism of lactic acid bacteria?

Cited by 166 publications

References 84 publications

Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

Suppressive Effects of Oral Administration of Heat-Killed <i>Lactobacillus acidophilus</i> on T Helper-17 Immune Responses in a Bovine β-Lactoglobulin-Sensitized Mice Model

Survival of Lactobacillus rhamnosus probiotic strains in peach jam during storage at different temperatures

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