Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

Sakai, Tohru; Taki, Tomoyo; Nakamoto, Akiko; Shuto, Emi; Tsutsumi, Rie; Toshimitsu, Takayuki; Makino, Seiya; Ikegami, Shuji

doi:10.3177/jnsv.59.144

Cited by 54 publications

(25 citation statements)

References 20 publications

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“…Gut microbiota affects the muscular energy utilization preference (7) and metabolites (26) via the gut muscle axis. Previous studies showed that mice administered L. plantarum could regulate blood glucose levels in response to insulin (21) and prevent metabolic disturbances induced by a high-fructose diet (25). Our results suggest that L. plantarum TWK10 probiotics are beneficial to energy harvesting possibly due to glycogenesis regulation for exercise demand (Figs.…”

Section: Discussionsupporting

confidence: 53%

Effect of Lactobacillus Plantarum TWK10 on Improving Endurance Performance in Humans

Huang

Hsu

et al. 2018

Chin. J. Physiol.

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Microbiota is currently an important issue in disease and health and many studies have revealed it to play an important role in physiological homeostasis and health promotion. Lactobacillus plantarum (L. plantarum), isolated from Taiwan pickled vegetables, is a well-known probiotic microorganism. In a recent animal study, it was shown that supplementation of mice with L. plantarum TWK10 (TWK10) could increase muscle mass, improve exercise performance and exert anti-fatigue effects. In order to examine the ergogenic effect of TWK10 supplementation on endurance performance in humans, we conducted a human double-blind placebo-controlled clinical study. A total of sixteen adult subjects over 20 years of age were recruited and randomly allocated to the placebo or TWK10 group (n = 8 each). The TWK10 group received 6 weeks of supplementation. Physiological assessments were conducted by exhaustive treadmill exercise measurements and related biochemical indexes. After 6 weeks of supplementation, levels of lactic acid, blood ammonia, blood glucose, free fatty acid (FFA) and creatine kinase (CK) were evaluated during exhaustive exercise. We were able to show that the TWK10 group had significantly higher endurance performance and glucose content in a maximal treadmill running test compared to the placebo group (P < 0.05), suggesting that TWK10 supplementation may be beneficial to energy harvest. Taken together, our results suggest that TWK10 has the potential to be an aerobic exercise supplement for physiological adaptation or an ergogenic supplement with health benefits for amateur runners.

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Section: Discussionsupporting

confidence: 53%

Effect of Lactobacillus Plantarum TWK10 on Improving Endurance Performance in Humans

Huang

Hsu

et al. 2018

Chin. J. Physiol.

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“…Although the blood glucose concentrations were not significantly reduced in KKAy mice treated with OLL2712, an observable trend toward reduced rates of elevation of blood glucose concentrations was noted in the OLL2712 group compared with the control group (P = 0.09, Table 2). In a previous report, however, we demonstrated that OLL2712 administration significantly reduced blood glucose concentrations after insulin treatment in a dietinduced obesity model (Sakai et al, 2013). Accordingly, it is also possible that the administration of OLL2712 may be effective in ameliorating hyperglycemia.…”

mentioning

confidence: 67%

Identification of a Lactobacillus plantarum strain that ameliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice

Toshimitsu

Mochizuki

Ikegami

et al. 2016

Journal of Dairy Science

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In this study, we identified a strain of lactic acid bacteria (LAB) that induces high levels of IL-10 production by immune cells, and evaluated the ability of the strain to suppress chronic inflammation and ameliorate metabolic disorders in in vitro and in vivo models. Among a collection of LAB strains, Lactobacillus plantarum strain OLL2712 (OLL2712) induced the highest levels of IL-10 production in mouse-derived dendritic cells and peritoneal macrophages. The anti-inflammatory effects of this strain were evaluated using a co-culture system comprising RAW 264.7 and 3T3-L1 cells. We also administered heat-killed OLL2712 to obese and type 2 diabetic KKAy mice for 3 wk to evaluate the in vivo effects of the strain. The OLL2712 significantly decreased the production of proinflammatory cytokines in vitro. Likewise, the administration of OLL2712 significantly suppressed proinflammatory cytokine levels in both the visceral adipose tissue and the serum of KKAy mice, and reduced serum triglyceride concentrations. The strain also alleviated oxidative stress and adrenaline levels in the serum of KKAy mice. On the other hand, Lactobacillus gasseri strain MEP222804 (a moderate IL-10 inducer) did not ameliorate the systemic inflammation and hyperlipidemia in KKAy mice. Our results suggest that treatment with strong IL-10-inducing LAB has the potential to ameliorate metabolic disorders by suppressing chronic inflammation in the host animal.

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“…These effects were associated with increased number of Bifidobacterium and Lactobacillus strains. In high-fat diet-induced obese mice and streptozotocin- or alloxan-induced diabetic rats, administration of L. plantarum , L. acidophilus , or L. casei resulted in reduction of body weight, hyperglycemia, epididymal fat, triglyceride, insulin and leptin, lipase activity, non-esterified fatty acids, triglyceride, low density lipoprotein (LDL)-cholesterol, LDL/HDL (high density lipoprotein) ratio, and adipocyte interleukin-1beta mRNA expression [40–43]. Supplementation with this probiotic also increased HDL-cholesterol, improved immunological parameters and exerted protective effects on the pancreas, liver and kidney.…”

Section: Modulation Of Gut Microbiota In the Management Of Metabolic mentioning

confidence: 99%

Modulation of Gut Microbiota in the Management of Metabolic Disorders: The Prospects and Challenges

Erejuwa

Sulaiman

Wahab

2014

IJMS

111

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The gut microbiota plays a number of important roles including digestion, metabolism, extraction of nutrients, synthesis of vitamins, prevention against pathogen colonization, and modulation of the immune system. Alterations or changes in composition and biodiversity of the gut microbiota have been associated with many gastrointestinal tract (GIT) disorders such as inflammatory bowel disease and colon cancer. Recent evidence suggests that altered composition and diversity of gut microbiota may play a role in the increased prevalence of metabolic diseases. This review article has two main objectives. First, it underscores approaches (such as probiotics, prebiotics, antimicrobial agents, bariatric surgery, and weight loss strategies) and their prospects in modulating the gut microbiota in the management of metabolic diseases. Second, it highlights some of the current challenges and discusses areas of future research as it relates to the gut microbiota and metabolic diseases. The prospect of modulating the gut microbiota seems promising. However, considering that research investigating the role of gut microbiota in metabolic diseases is still in its infancy, more rigorous and well-designed in vitro, animal and clinical studies are needed.

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Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

Cited by 54 publications

References 20 publications

Effect of Lactobacillus Plantarum TWK10 on Improving Endurance Performance in Humans

Effect of Lactobacillus Plantarum TWK10 on Improving Endurance Performance in Humans

Identification of a Lactobacillus plantarum strain that ameliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice

Modulation of Gut Microbiota in the Management of Metabolic Disorders: The Prospects and Challenges

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