Anti-Alzheimer, antidiabetic and antioxidant potential of Satureja cuneifolia and analysis of its phenolic contents by LC-MS/MS

Taslimi, Parham; Köksal, Ekrem; Gören, Ahmet; Bursal, Ercan; Aras, Abdülmelik; Kılıç, Ömer; Alwasel, Saleh; Gülçın, İlhami

doi:10.1016/j.arabjc.2019.10.002

Cited by 110 publications

(85 citation statements)

References 55 publications

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“…Structural Motif (26)(27)(28)(29)(30)(31)(32) Step 1: Starting dichlorotriazinyl benzene sulfonamide (1 mmol) was dissolved in 10 mL of DMF. One mmol of solid anhydrous potassium carbonate was added in small portions, and the mixture was stirred for 10 min.…”

Section: General Methods For Synthesis Of Trisubstituted Derivatives Omentioning

confidence: 99%

“…Antioxidants possess great potential as drugs suitable for the treatment of various diseases related to oxidative stress. In particular, the use of compounds containing phenol structural moiety in the treatment of Alzheimer's disease [32][33][34][35][36], Parkinson´s disease [37][38][39], Huntington´s disease [40,41], and cancer [42][43][44][45] have been extensively studied in the last two years. Their structural diversity provides many possibilities for the design and synthesis of new, highly effective agents.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs

et al. 2020

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A series of 1,3,5-triazine analogues, incorporating aminobenzene sulfonamide, aminoalcohol/phenol, piperazine, chalcone, or stilbene structural motifs, were evaluated as potential antioxidants. The compounds were prepared by using step-by-step nucleophilic substitution of chlorine atoms in starting 2,4,6-trichloro-1,3,5-triazine. Reactions were catalyzed by Cu(I)-supported on a weakly acidic resin. The radical scavenging activity was determined in terms of %inhibition activity and EC50, using the ABTS method. Trolox and ascorbic acid (ASA) were used as standards. In the lowest concentration 1 × 10−4 M, the %inhibition activity values at 0 min were comparable with both standards at least for 10 compounds. After 60 min, compounds 5, 6, 13, and 25 showed nearly twice %inhibition (73.44–87.09%) in comparison with the standards (Trolox = 41.49%; ASA = 31.07%). Values of EC50 at 60 min (17.16–27.78 μM) were 5 times lower for compounds 5, 6, 13, and 25 than EC50 of both standards (trolox = 178.33 μM; ASA = 147.47 μM). Values of EC50 correlated with %inhibition activity. Based on these results, the presented 1,3,5-triazine analogues have a high potential in the treatment of illnesses caused or related to oxidative stress.

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Section: General Methods For Synthesis Of Trisubstituted Derivatives Omentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs

et al. 2020

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“…The inhibitory effect of the N-substituted pyrimidinethione and acetophenone derivatives (A1-A5, B1-B11, and C1-C11) on the α-glycosidase enzyme activity was assayed using p-nitrophenyl-Dglycopyranoside (p-NPG) substrate, according to the assay of Tao et al [18] as described previously. [35][36][37] First, 200 µl of phosphate buffer was mixed with 40 µl of the homogenate solution in a phosphate-buffered solution (PBS; 0.15 U/ml, pH 7.4). Also, 50 µl of p-NPG in a PBS (5 mM, pH 7.4)…”

Section: α-Glycosidase Inhibition Assaymentioning

confidence: 99%

N‐Substituted pyrimidinethione and acetophenone derivatives as a new therapeutic approach in diabetes

Taslimi

Sujayev

Karaman

et al. 2020

Archiv der Pharmazie

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In this study, compounds with 4‐hydroxybutyl, 4‐phenyl, 5‐carboxylate, and pyrimidine moieties were determined as α‐glycosidase inhibitors. N‐Substituted pyrimidinethione and acetophenone derivatives (A1–A5, B1–B11, and C1–C11) were good inhibitors of the α‐glycosidase enzyme, with Ki values in the range of 104.27 ± 15.75 to 1,004.25 ± 100.43 nM. Among them, compound B7 was recorded as the best inhibitor, with a Ki of 104.27 ± 15.75 nM against α‐glycosidase. In silico studies were carried out to clarify the binding affinity and interaction mode of the compounds with the best inhibition score against α‐glycosidase from Saccharomyces cerevisiae. Compounds B7 (S) and B11 (R) exhibited a good binding affinity with docking scores of −8.608 and 8.582 kcal/mol, respectively. The docking results also showed that the 4‐hydroxybutyl and pyrimidinethione moieties play a key role in S. cerevisiae and human α‐glycosidase inhibition.

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“…Diabetes mellitus is a chronic metabolic disorder ( Golbidi et al., 2012 ) characterized by means of abnormally high plasma glucose, give rise to diabetic complications which include diabetic neuropathy ( Ziegler et al., 1995 ), retinopathy ( Hammes et al., 2003 ), nephropathy ( Lim, 2014 ) and cardiovascular diseases ( Levine et al., 2006 ). Diabetes is a fast increasing life style related disease ( Taslimi et al., 2020 ; Bouguerra et al., 2007 ) that requires the significant persisted research, therefore, there is an urgent need for novel approaches to prevent and deal with this pandemic.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugs

Dayma

Chopra

Sharma

et al. 2020

Heliyon

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The present study is aimed to investigate the anti-inflammatory, antioxidant and antidiabetic activities of three series of hydroxytriazenes based on sulfa drugs viz; Sulphathiazole (ST), Sulfisoxazole (SF) and Sulphamethoxazole (SM). Antidiabetic activities of the synthesized hydroxytriazenes were investigated by α-glucosidase and α-amylase inhibition method and IC 50 values were recorded. The compounds presented significant α-glucosidase and α-amylase inhibition effect with IC 50 values ranging from 122 to 341 μg/mL. Anti-inflammatory activity was also investigated by carrageenan-induced paw edema (CPE) method, where % inhibition was up to 89% after 4 h of treatment and antioxidant properties of the similar compounds were assessed by DPPH and ABTS radical scavenging assays. Antioxidant capacity of all the hydroxytriazenes detected by ABTS assay, was significantly higher as compared to DPPH assay. The hydroxytriazenes having highest antioxidant capacity presented IC 50 values for compound ST-1 and ST-6 are 488 μg/mL for DPPH, 54.12 μg/mL for ABTS and 858.5 μg/mL for DPPH, 48.0 μg/mL for ABTS, respectively. These results suggested that ABTS assay may be more useful than DPPH assay for synthetic antioxidants. The findings from the molecular docking experiments may also expand the formation of new potent sulpha drugs based hydroxytriazenes targeting towards the subunit of C-terminal of human maltaseglucoamylase for the treatment of diabetes metabolic disorder. Overall, highlight the multifunctional role of hydroxytriazenes as antidiabetic, antioxidant and anti-inflammatory agents.

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Anti-Alzheimer, antidiabetic and antioxidant potential of Satureja cuneifolia and analysis of its phenolic contents by LC-MS/MS

Cited by 110 publications

References 55 publications

Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs

Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs

N‐Substituted pyrimidinethione and acetophenone derivatives as a new therapeutic approach in diabetes

Synthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugs

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