Anti-Alzheimer's Activity of aqueous extract of leaves of <i>Murraya koenigii</i> in Aluminium chloride Induced Neurotoxicity in rats

Reddy, B. Maheswari; Dhanapal, C. K.; Lakshmi, B. V. S.

doi:10.5958/0974-360x.2019.00323.8

Cited by 6 publications

(3 citation statements)

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“…This section describes the neuroprotective effects of M. koenigii leaf extracts and specified metabolites against their potential targets in NDs. The oral administration of the leaf aqueous extract (100, 200, 400 mg/kg body weight) to aluminum-treated rats was found to significantly restore antioxidant parameters (Catalase: CAT, Glutathione reduced: GSH, Lipid peroxidation: LPO), reversing them to normal through the neuroprotective properties of the extract [58]. The protective effect of M. koenigii on oxidative stress was most likely due to carbazole alkaloids, polyphenols, and flavonoids, which are known to have antioxidant properties [52,59,60].…”

Section: Phytochemicals Of Murraya Koenigii and Their Role In Neurode...mentioning

confidence: 99%

Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases

Tan

Sharma

2022

Pharmaceuticals

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Neurodegenerative diseases (NDs) mainly affect neurons and gradually lead to a loss of normal motor and cognitive functions. Atypical protein homeostasis—misfolding, aggregations and accumulations, oxidative stress, inflammation, and apoptosis—are common features in most NDs. To date, due to the complex etiology and pathogenesis of NDs, no defined treatment is available. There has been increasing interest in plant extracts as potential alternative medicines as the presence of various active components may exert synergistic and multi-pharmacological effects. Murraya koenigii (Rutaceae) is utilized in Ayurvedic medicine for various ailments. Pharmacological studies evidenced its potential antioxidant, anti-inflammatory, anticancer, hepatoprotective, immunomodulatory, antimicrobial, and neuroprotective activities, among others. In line with our interest in exploring natural agents for the treatment of neurodegenerative diseases, this review presents an overview of literature concerning the mechanisms of action and the safety profile of significant bioactive components present in M. koenigii leaves to support further investigations into their neuroprotective therapeutic potential.

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Section: Phytochemicals Of Murraya Koenigii and Their Role In Neurode...mentioning

confidence: 99%

Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases

Tan

Sharma

2022

Pharmaceuticals

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“…Restored the altered neurological and antioxidant effects in rats [122] Alcohol extract Leaves -Haloperidol-induced Orofacial dyskinesia Significantly decreased the LPO levels and even restored the reduced GSH levels Mild neuroprotective effect through glutamate receptors [123] Methanol extract Leaves -…”

Section: Leaves -Aluminum Chloride-induced Neurobehavioral and Pathol...mentioning

confidence: 99%

“…Additionally, o‐methylmurrayamine A, mukolidine and murrayakonine A were able to inhibit the release of IL‐6, TNF‐α in LPS‐induced inflammation [73] . The pharmacological activities of various extract on M. koenigii (L.) Spreng are discussed in Table 4 [39,45–46,58,62,69–70,74–149] and Figure 5 along with various patents on M. koenigii (L.) Spreng showed in Table 5 [150–157]…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Phyto‐Pharmacological Review onMurraya koenigii(L.) Spreng: As an Indigenous Plant of India with High Medicinal Potential

Singh

Ahuja

Murti

et al. 2023

Chemistry & Biodiversity

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The medicinal aspects of Murraya koenigii (L.) Spreng. It also provides the latest updated information on pharmacological and plant patents on phytoconstituents. The information was collected from various sources, including literature surveys, textbooks, databases, and internet sources like Scopus, Science Direct, Pubmed, Springer, Google Scholar, Taylor and Francis. The plant, Murraya koenigii (L.) Spreng is an extensive valuable, and important medicinal plant in the Indian System of Medicine. The plant proved to show various ethnomedicinal uses mentioned in the literature and even possessed various pharmacological activities. Different bioactive metabolites exhibit several biological activities. However, the biological efficacies of various other chemical constituents are yet to be clarified and proved concerning the molecular mechanisms.

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Ethnomedicinal plants used for the treatment of neurodegenerative diseases in Himachal Pradesh, India in Western Himalaya

Sharma

Verma

Kumar

et al. 2022

Journal of Ethnopharmacology

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Anti-Alzheimer's Activity of aqueous extract of leaves of Murraya koenigii in Aluminium chloride Induced Neurotoxicity in rats

Cited by 6 publications

References 0 publications

Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases

Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases

Phyto‐Pharmacological Review onMurraya koenigii(L.) Spreng: As an Indigenous Plant of India with High Medicinal Potential

Ethnomedicinal plants used for the treatment of neurodegenerative diseases in Himachal Pradesh, India in Western Himalaya

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