Anti-Angiogenetic Agents from the Sea: A New Potential Preventive and Therapeutic Wave?

Abstract

<jats:sec> <jats:title>:</jats:title> <jats:p>Angiogenesis, the generation of novel blood vessels form pre-existing ones, is a prerequisite for the physiological expansion, reparation, and functioning of body tissues and systems. However it is also involved in some pathological inflammatory situations, such as oncologic and chronic degenerative disorders. A correct angiogenesis and neo-vascular response also accompanies wound healing, interaction with biocompatible materials and tissue regeneration. In this respect, natural products deriving from terrestrial and marine plants/organisms may prevent and even cure various angiogenesis-dependent disorders. Bioactive natural compounds with antioxidant and anti-inflammatory activities could concur to maintain an adequate vascularization and endothelial functions and to inhibit angiogenesis, thus controlling tumor development. This review aims to illustrate the role of some marine-derived compounds as anti-angiogenetic agents</jats:p> </jats:sec>