Anti-angiogenic activity of the methanol extract and its fractions of Ulmus davidiana var. japonica

Chorioallantoic membrane assays have been based on diffusion control—Problems arising with a diversity of mass transfers in egg white

“…Whatever medicines applied, the initial concentration applied to CAM was seen to range from 0.03 to 100 g/egg (or 5-100 nmol/egg) [5,12], which correspondingly yielded instantaneous concentration of 0.006-20 g/mL (or 1.0-20 nmol/mL) in the "capping volume V ABD " ( Table 2). Further estimation indicated Table 3 Estimated reaction control regime.…”

“…Up to present, a huge number of documents had performed anti-angiogenic test with chorioallantoic membrane assay (CAM) [4][5][6][7][8][9][10][11][12]. Because of the presence of great variation in composition in egg white [13][14][15] and the diversity of chemical structures and polarity of the medicines tested [16], the question arises with "Can CAM accurately reflect the inherent response of a biological system to therapeutics with respect to angiogenic status?"…”

Isolation and Anti-Inflammatory Activity of Bakuchiol fromUlmus davidianavar.japonica

“…4,6 In addition, extracts from this plant inhibited angiogenesis, boosted immunocompetence, and reduced inflammation. [7][8][9] The present study reports the isolation of an antiinflammatory agent (Compound 1) from U. davidiana var. japonica.…”

<i>Ulmus davidiana</i> var <i>japonica</i> Attenuates Neuroinflammatory Responses in Activated BV2 Murine Microglial Cells via Nuclear Factor-KappaB Signaling Pathway

“…Previous studies have shown that UDE or its isolated components have various effects, including anti-oxidation [2,3], antiinflammatory [3], and possibly anti-angiogenic effect [4].…”